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公开(公告)号：US20230390185A1
公开(公告)日：2023-12-07
申请号：US18450240
申请日：2023-08-15
Applicant: BASF SE
Inventor： LaTonya KILPATRICK-LIVERMAN , Jianhong Qiu , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Nina Schneider , Ralph Peter Santarpia, III , Volker Wendel
IPC: A61K8/9794 , A61K8/64 , A61Q11/00
CPC classification number: A61K8/9794 , A61K8/645 , A61Q11/00
Abstract: Provided herein are, inter alia, methods of treating, repairing, mitigating, and/or reducing the incidence, size or visibility of white spot lesions on teeth by administering oral care compositions comprising partially hydrolyzed plant protein.
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公开(公告)号：US20130337512A1
公开(公告)日：2013-12-19
申请号：US13942184
申请日：2013-07-15
Applicant: BASF SE
Inventor： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Krauser , Wolf-Rüdiger Krahnert
IPC: C12P13/00
CPC classification number: C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
Abstract: Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
Abstract translation: 制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或 芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到 根据权利要求1的通过加入多肽的对映选择性脱酰作用。
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公开(公告)号：US10507340B2
公开(公告)日：2019-12-17
申请号：US15770978
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-Liverman , Lynette Zaidel
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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公开(公告)号：US20150147800A1
公开(公告)日：2015-05-28
申请号：US14584289
申请日：2014-12-29
Applicant: BASF SE
Inventor： Bernhard Hauer , Nina Schneider , Krzysztof Okrasa , Jason Micklefield , David Leys , Colin Levy
IPC: C12N9/88
CPC classification number: C12N9/88 , C07K14/235 , C07K2299/00 , C12N9/90 , C12P7/40 , C12P7/42 , C12Q1/00 , C12Y401/01075 , C12Y401/01076 , G01N2333/235 , G01N2500/00
Abstract: The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.
Abstract translation: 本发明涉及由结构和/或与芳基丙二酸酯脱羧酶（AMDase）功能相关的酶催化的由在博德特氏菌属微生物分离的酶催化的丙二酸（丙二酸）衍生物的酶脱羧的方法。 本发明还涉及具有脱羧酶活性的新型酶，可用于实施要求保护的方法，其突变体，相应的编码序列和表达系统，制备所述新型酶的方法，以及筛选获得还具有所述脱羧酶活性的合适酶的筛选方法 。
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Patent Agency Ranking
公开(公告)号：US20180303740A1
公开(公告)日：2018-10-25
申请号：US15770977
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-Liverman , Lynette Zaidel , Melanie Melcher , Thorsten Henkes , Sandra Facey , Bernhard Hauer
Abstract: Provided herein are oral care compositions comprising Hydrophobin-like proteins (HLPs), which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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公开(公告)号：US10898739B2
公开(公告)日：2021-01-26
申请号：US16715273
申请日：2019-12-16
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-liverman , Lynette Zaidel
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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公开(公告)号：US20190201721A1
公开(公告)日：2019-07-04
申请号：US15771236
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Thorsten Henkes , Sandra Facey , Bernhard Hauer
Abstract: Provided herein are oral care compositions comprising HABP, which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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公开(公告)号：US20190022429A1
公开(公告)日：2019-01-24
申请号：US15770978
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-Liverman , Lynette Zaidel
CPC classification number: A61Q11/00 , A61K8/21 , A61K8/64 , A61K9/0058
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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公开(公告)号：US08932837B2
公开(公告)日：2015-01-13
申请号：US13942184
申请日：2013-07-15
Applicant: BASF SE
Inventor： Bernhard Hauer , Thomas Friedrich , Rainer Stürmer , Nina Schneider , Susanne Sabrowski , Wolf-Rüdiger Krahnert
CPC classification number: C12P13/001 , C12N9/80 , C12P13/04 , C12P41/007
Abstract: Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which R1 stands for alkyl, alkoxyalkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or hetaryl, and R2 stands for alkyl, cycloalkyl or aryl, in which an enantiomeric mixture of a simply N-acylated 3-aminocarboxylic acid ester of general formula (I.b), in which R1 and R2 have the meanings given above and R3 stands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim 1.
Abstract translation: 制备通式I的光学活性3-氨基羧酸酯化合物及其铵盐的方法，其中R1代表烷基，烷氧基烷基，烯基，环烷基，杂环烷基，芳基或杂芳基，R2代表烷基，环烷基或 芳基，其中通式（Ib）的简单N-酰化3-氨基羧酸酯的对映体混合物，其中R 1和R 2具有上面给出的含义，R 3代表氢，烷基，环烷基或芳基，被提交到 根据权利要求1的通过加入多肽的对映选择性脱酰作用。
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