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公开(公告)号：US20230390185A1
公开(公告)日：2023-12-07
申请号：US18450240
申请日：2023-08-15
Applicant: BASF SE
Inventor： LaTonya KILPATRICK-LIVERMAN , Jianhong Qiu , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Nina Schneider , Ralph Peter Santarpia, III , Volker Wendel
IPC: A61K8/9794 , A61K8/64 , A61Q11/00
CPC classification number: A61K8/9794 , A61K8/645 , A61Q11/00
Abstract: Provided herein are, inter alia, methods of treating, repairing, mitigating, and/or reducing the incidence, size or visibility of white spot lesions on teeth by administering oral care compositions comprising partially hydrolyzed plant protein.
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2.发明授权公开(公告)号：US09718839B2
公开(公告)日：2017-08-01
申请号：US14533345
申请日：2014-11-05
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , A23L1/30 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/506 , A61K31/5377 , A61K8/49 , A61Q11/00 , C07D401/04 , C07D491/147 , A23G3/36 , A23G4/06 , A23L2/52 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/513 , A61Q19/00 , C07C233/11 , C07C235/36 , C07C235/38 , C07D213/75 , C07D317/60 , C07D405/12 , C07D495/22 , C09D5/16 , D06M15/03 , D06M15/07 , D06M16/00 , A23L27/20 , A23L33/10 , A61Q17/04
CPC classification number: C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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3.发明授权公开(公告)号：US11434220B2
公开(公告)日：2022-09-06
申请号：US16642954
申请日：2018-08-31
Applicant: BASF SE , SYMRISE AG
Inventor： Benoît Join , Jekaterina Ongouta , Michael Backes , Rahim Brodhage , Arnold Machinek , Hubert Loges , Susanne Mundt , Tom Somers , Thomas Subkowski , Jens Wittenberg , Martin Weisel , Wolfgang Siegel , Claus Bollschweiler , Ralf Pelzer
IPC: C07D317/46 , C07C323/41 , C07D405/12 , C07D213/75 , C07D231/40 , C07D407/12 , C07D307/14 , C07D409/12 , C07D409/14 , C07D405/14 , A61K8/49 , A61K8/46 , A61Q11/00 , A23L29/00 , A23L27/00 , A23G3/36
Abstract: The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.
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公开(公告)号：US11044931B2
公开(公告)日：2021-06-29
申请号：US16524437
申请日：2019-07-29
Applicant: BASF SE
Inventor： Thomas Subkowski , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel , Ralf Pelzer
IPC: A23L27/20 , A61Q19/00 , A61K8/49 , C07J63/00 , C07C49/675 , A61K8/35 , A61K8/55 , C07D339/08 , C07D339/06 , C07D495/10 , C07D493/10 , C07D311/94 , C07D311/78 , C07D405/06 , C07D209/48 , C07D471/04 , C07D495/20 , C07D491/20 , C07F9/572 , A23L27/00 , C07J73/00 , C07J33/00 , C07C49/665 , C07J11/00
Abstract: The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.
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公开(公告)号：US10507340B2
公开(公告)日：2019-12-17
申请号：US15770978
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-Liverman , Lynette Zaidel
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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Patent Agency Ranking
公开(公告)号：US20180303740A1
公开(公告)日：2018-10-25
申请号：US15770977
申请日：2016-10-25
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-Liverman , Lynette Zaidel , Melanie Melcher , Thorsten Henkes , Sandra Facey , Bernhard Hauer
Abstract: Provided herein are oral care compositions comprising Hydrophobin-like proteins (HLPs), which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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7.发明申请公开(公告)号：US20180093997A1
公开(公告)日：2018-04-05
申请号：US15629015
申请日：2017-06-21
Applicant: SYMRISE AG , BASF SE
Inventor： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC: C07D495/20 , C07D491/147 , A24B13/00 , A24D1/00 , A61K31/4375 , A61K31/438 , A61K31/5377 , A61Q11/00 , A23L33/10 , A23L27/20 , D06M16/00 , D06M15/07 , D06M15/03 , C09D5/16 , C07D495/22 , C07D405/12 , C07D401/04 , C07D317/60 , C07D213/75 , C07C235/38 , C07C235/36 , C07C233/11
Abstract: The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
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公开(公告)号：US20170265510A1
公开(公告)日：2017-09-21
申请号：US15610958
申请日：2017-06-01
Applicant: BASF SE
Inventor： THOMAS SUBKOWSKI , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel , Ralf Pelzer
IPC: A23L27/20 , A23L27/00 , A61K8/35 , A61K8/49 , A61K8/55 , A61Q19/00 , C07C49/665 , C07C49/675 , C07D209/48 , C07D311/78 , C07D311/94 , C07D339/06 , C07D339/08 , C07D405/06 , C07D471/04 , C07D491/20 , C07D493/10 , C07D495/10 , C07D495/20 , C07F9/572 , C07J33/00 , C07J63/00 , C07J73/00 , C07J11/00
CPC classification number: A23L27/2056 , A23L27/88 , A61K8/35 , A61K8/49 , A61K8/492 , A61K8/4926 , A61K8/498 , A61K8/4986 , A61K8/55 , A61K2800/244 , A61Q19/00 , C07C49/665 , C07C49/675 , C07C2603/26 , C07D209/48 , C07D311/78 , C07D311/94 , C07D339/06 , C07D339/08 , C07D405/06 , C07D471/04 , C07D491/20 , C07D493/10 , C07D495/10 , C07D495/20 , C07F9/5728 , C07J11/00 , C07J33/007 , C07J63/008 , C07J73/003
Abstract: The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.
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9.发明申请LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF 审中-公开冷冻受体TRPM8的低分子量重量调节剂及其用途公开(公告)号：US20130251647A1
公开(公告)日：2013-09-26
申请号：US13623378
申请日：2012-09-20
Applicant: BASF SE
Inventor： Thomas Subkowski , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel , Ralf Pelzer
IPC: A23L1/22 , C07D495/20 , C07D471/04 , C07D209/48 , C07F9/572 , C07D405/06 , C07D311/78 , C07D311/94 , C07D493/10 , C07D495/10 , C07C49/665 , C07D339/06 , C07D339/08 , A61K8/49 , A61K8/55 , A61K8/35 , A61Q19/00 , C07D491/20
CPC classification number: A23L27/2056 , A23L27/88 , A61K8/35 , A61K8/49 , A61K8/492 , A61K8/4926 , A61K8/498 , A61K8/4986 , A61K8/55 , A61K2800/244 , A61Q19/00 , C07C49/665 , C07C49/675 , C07C2603/26 , C07D209/48 , C07D311/78 , C07D311/94 , C07D339/06 , C07D339/08 , C07D405/06 , C07D471/04 , C07D491/20 , C07D493/10 , C07D495/10 , C07D495/20 , C07F9/5728 , C07J11/00 , C07J33/007 , C07J63/008 , C07J73/003
Abstract: The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.
Abstract translation: 本发明涉及冷薄荷醇受体TRPM8的新型调节剂，使用这些调节剂调节TRPM8受体的方法; 特别是使用调节剂诱导感冒的感觉; 以及使用这些调节剂制备的制品和组合物。
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公开(公告)号：US10898739B2
公开(公告)日：2021-01-26
申请号：US16715273
申请日：2019-12-16
Applicant: BASF SE
Inventor： Nina Schneider , Thomas Subkowski , Stefan Jenewein , Marvin Karos , Claus Bollschweiler , Volker Wendel , Jianhong Qiu , LaTonya Kilpatrick-liverman , Lynette Zaidel
Abstract: Provided herein are oral care compositions comprising antifreeze proteins (AFPs) useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
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