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公开(公告)号：US12226775B2
公开(公告)日：2025-02-18
申请号：US17419970
申请日：2020-09-25
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Qiuxu Wei , Yingying Zhao , Wenliang Yao , Bolin Fan , Le Gu , Yongjia Gao
IPC: B01L3/00 , B01F23/00 , B01F23/41 , B01F101/23 , B01L9/00 , B23Q17/24 , C07K14/705 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N21/17 , G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N21/64 , G01N21/77 , G01N21/78 , G01N27/414 , G01N30/12 , G01N30/68 , G01N30/70 , G01N30/72 , G01N30/88 , G01N33/00 , G01N33/18 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/74 , G01N35/00 , G01N35/10 , G06T7/00 , G06T7/90 , H10K10/46 , H10K85/00 , H10K85/20
Abstract: An embodiment of the present disclosure provides a microfluidic chip, including: a first substrate; wherein the first substrate includes a first base, a first electrode layer on the first base; the first electrode layer includes a plurality of first electrodes at intervals along a first direction, wherein a cross-sectional shape of the first electrode parallel to the first base is a centrosymmetric shape, and the cross-sectional shape includes: a first boundary and a second boundary opposite to each other in the first direction; a shape of the first boundary is a centrosymmetric curve, a distance between two end points of the first boundary in a second direction perpendicular to the first direction is less than a length of the first boundary; the second boundary has a same shape and length as the first boundary, and the first and second boundaries are parallel to each other in the first direction.
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公开(公告)号：US12257582B2
公开(公告)日：2025-03-25
申请号：US16898516
申请日：2020-06-11
Inventor： Hui Liao , Yingying Zhao , Wenliang Yao , Bolin Fan , Nan Zhao , Le Gu , Yongjia Gao
Abstract: The present disclosure discloses a sample preliminary screening chip, a specimen detecting method and a screening device. A data processor may be configured to control a sample solution containing a specimen to be added into a preliminary screening inlet of the sample preliminary screening chip, and control the sample solution in the preliminary screening inlet to enter a channel, successively to flow through a first preliminary screening area and a second preliminary screening area, and to flow out from a preliminary screening outlet so as to store a liquid with the specimen in a first preliminary screening area. In this way, the liquid containing the specimen may be screened preliminarily.
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公开(公告)号：US11684916B2
公开(公告)日：2023-06-27
申请号：US16632934
申请日：2019-01-09
Inventor： Wenliang Yao , Nan Zhao , Haochen Cui , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Chuncheng Che
CPC classification number: B01L3/502715 , C12Q1/686 , B01L2300/0645 , B01L2300/1827
Abstract: A chip for polymerase chain reaction, a method of operating a chip for polymerase chain reaction, and a reaction device are provided. The chip includes: a sample adding region, a mixing region, a temperature cycling region in a sequential arrangement, and at least one driving unit group. The at least one driving unit group includes a plurality of driving units and is configured to drive a liquid drop to move and sequentially pass through the sample adding region, the mixing region, and the temperature cycling region.
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公开(公告)号：US20210331162A1
公开(公告)日：2021-10-28
申请号：US16626490
申请日：2019-07-26
Inventor： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US11865538B2
公开(公告)日：2024-01-09
申请号：US16757902
申请日：2019-03-27
Inventor： Wenliang Yao , Nan Zhao , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Bolin Fan
IPC: B01L3/00 , G01N33/487 , H01L27/12
CPC classification number: B01L3/502715 , G01N33/48707 , H01L27/1214 , B01L2300/0645 , B01L2300/0819
Abstract: A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
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Patent Agency Ranking
公开(公告)号：US11498068B2
公开(公告)日：2022-11-15
申请号：US16632931
申请日：2019-01-02
Inventor： Wenliang Yao , Haochen Cui , Peizhi Cai , Yuelei Xiao , Fengchun Pang , Yue Geng , Le Gu , Nan Zhao , Hui Liao , Yingying Zhao , Chuncheng Che
IPC: B01L3/00
Abstract: A microfluidic device, a microfluidic detection assembly and a detection method for the microfluidic device. The microfluidic device includes a first substrate and a second substrate; the first substrate and the second substrate are oppositely arranged to define a channel between the first substrate and the second substrate, the channel is configured for liquid to flow, the first substrate includes a base substrate and a plurality of control assemblies which are arranged on the base substrate along an extending direction of the channel, each of the plurality of control assemblies includes: a first electrode, a second electrode and a plurality of coils, and the first electrode is configured to input currents into the plurality of coils, and the plurality of coils are connected in parallel to the second electrode.
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公开(公告)号：US12251698B2
公开(公告)日：2025-03-18
申请号：US17489920
申请日：2021-09-30
Inventor： Qiuxu Wei , Wenliang Yao , Yingying Zhao , Le Gu , Bolin Fan , Yongjia Gao
IPC: B01L3/00
Abstract: The disclosure provides a micro-fluidic chip, and belongs to the field of chip technology. The microfluidic chip provided in the present disclosure includes a plurality of microfluidic units, each microfluidic unit includes an operation region and a transition region located on at least one side of the operation region, the transition regions at adjacent side of two adjacent microfluidic units are disposed opposite to each other. Each microfluidic unit includes: a first substrate; a first electrode layer disposed on the first substrate, the first electrode layer including a plurality of first sub-electrodes located in the operation region and at least one second sub-electrode located in the transition region, and the at least one second sub-electrode configured to drive a droplet to move from one of the plurality of microfluidic units to an adjacent microfluidic unit.
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公开(公告)号：US11583855B2
公开(公告)日：2023-02-21
申请号：US17186186
申请日：2021-02-26
Inventor： Hui Liao , Yingying Zhao , Bolin Fan , Wenliang Yao , Nan Zhao , Le Gu , Yongjia Gao
IPC: B01L3/00 , G01N27/22 , G01N33/577
Abstract: The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US11577246B2
公开(公告)日：2023-02-14
申请号：US16631780
申请日：2019-05-13
Inventor： Le Gu , Peizhi Cai , Fengchun Pang , Yue Geng , Yingying Zhao , Haochen Cui , Yuelei Xiao , Hui Liao , Wenliang Yao , Nan Zhao
Abstract: A microfluidic device and a detection method for the microfluidic device are provided. The microfluidic device includes a driving substrate configured to drive a movement of a droplet; and a position detector configured to detect a position of the droplet on the driving substrate.
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公开(公告)号：US11383238B2
公开(公告)日：2022-07-12
申请号：US16626490
申请日：2019-07-26
Inventor： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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