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1.发明授权Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins 有权编码修饰的人类免疫缺陷病毒1型（HIV-1）组的核酸M共有包膜糖蛋白公开(公告)号：US08071107B2
公开(公告)日：2011-12-06
申请号：US10572638
申请日：2004-09-17
申请人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和大范围的HIV初级分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。
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公开(公告)号：US09844589B2
公开(公告)日：2017-12-19
申请号：US13137517
申请日：2011-08-23
申请人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
IPC分类号： A61K39/21 , C07K14/005 , C07K16/42 , A61K39/12 , A61K39/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.
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公开(公告)号：US20120087938A1
公开(公告)日：2012-04-12
申请号：US13137517
申请日：2011-08-23
申请人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
发明人： Barton F. Haynes , Feng Gao , Bette T. Korber , Beatrice H. Hahn , George M. Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和大范围的HIV初级分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。
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公开(公告)号：US20070178562A1
公开(公告)日：2007-08-02
申请号：US10572638
申请日：2004-09-17
申请人： Barton Haynes , Feng Gao , Bette Korber , Beatrice Hahn , George Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
发明人： Barton Haynes , Feng Gao , Bette Korber , Beatrice Hahn , George Shaw , Denise Kothe , Ying Ying Li , Julie Decker , Hua-Xin Liao
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和大范围的HIV初级分离物和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。
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公开(公告)号：US20100285106A1
公开(公告)日：2010-11-11
申请号：US12312587
申请日：2007-11-19
申请人： Barton F. Haynes , Nancy G. Smith , S.Munir Alam , Feng Gao , Hua-Xin Liao
发明人： Barton F. Haynes , Nancy G. Smith , S.Munir Alam , Feng Gao , Hua-Xin Liao
IPC分类号： A61K39/21 , A61K9/127 , A61K39/395 , A61P31/18 , A61P37/04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/385 , A61K39/39 , A61K39/39533 , A61K39/3955 , A61K39/42 , A61K2039/5256 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/6018 , C07K2319/04 , C12N15/86 , C12N2740/16122 , C12N2740/16134 , C12N2760/20243
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a multicomponent vaccine and method of using same to protect against HTV-I infection.
摘要翻译： 本发明一般涉及人类免疫缺陷病毒（HIV），特别涉及一种多组分疫苗及其使用方法来防止HTV-1感染。
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公开(公告)号：US20100104596A1
公开(公告)日：2010-04-29
申请号：US12450395
申请日：2008-03-27
申请人： Barton F. Haynes , Betle T. Korber , Beatrice H. Hahn , Tanmoy Bhattacharya , Gnana Ganakaram , Feng Gao , Ron Swanstrom , George Shaw , Barton F. Uaynes , Betle T Korber
发明人： Barton F. Haynes , Betle T. Korber , Beatrice H. Hahn , Tanmoy Bhattacharya , Gnana Ganakaram , Feng Gao , Ron Swanstrom , George Shaw , Barton F. Uaynes , Betle T Korber
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N2740/16122 , C12N2740/16134
摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.
摘要翻译： 本发明一般涉及人类免疫缺陷病毒（HIV），特别涉及在患者中诱导对HIV的免疫应答的方法以及适用于这种方法的免疫原。 本发明还涉及诊断测试试剂盒及其使用方法。
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7.发明授权Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 失效人类免疫缺陷病毒1型非亚型B分离株的参考克隆和序列公开(公告)号：US06897301B2
公开(公告)日：2005-05-24
申请号：US10290579
申请日：2002-11-08
申请人： Beatrice H. Hahn , George M. Shaw , Feng Gao
发明人： Beatrice H. Hahn , George M. Shaw , Feng Gao
IPC分类号： A01N63/00 , A01N63/04 , A61K8/22 , A61K8/60 , A61K8/66 , A61Q5/00 , A61Q11/00 , A61Q17/00 , A61Q19/00 , C07H21/02 , C07K14/16 , C09D5/02 , C09D5/14 , C11D3/00 , C11D3/20 , C11D3/386 , C11D3/48 , C12Q1/68 , C12Q1/70 , C07H21/04
CPC分类号： C07K14/005 , A01N63/00 , A01N63/04 , A61K8/22 , A61K8/602 , A61K8/66 , A61K2800/524 , A61Q5/00 , A61Q11/00 , A61Q17/005 , A61Q19/00 , C07H21/02 , C09D5/025 , C09D5/14 , C11D3/0078 , C11D3/2034 , C11D3/38654 , C11D3/48 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703 , A01N2300/00
摘要： The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.
摘要翻译： 公开了人类免疫缺陷病毒1型非亚型B分离株的11个分子克隆的基因组的核苷酸序列。 本发明涉及由这些序列编码和/或衍生自这些序列的核酸和肽及其在诊断方法中的用途和作为免疫原。
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公开(公告)号：US06521739B1
公开(公告)日：2003-02-18
申请号：US09206551
申请日：1998-12-07
申请人： Beatrice H. Hahn , Feng Gao , George M. Shaw , Preston A. Marx , Stephen M. Smith , Marie Claude Georges-Courbot , Chang Yong Lu
发明人： Beatrice H. Hahn , Feng Gao , George M. Shaw , Preston A. Marx , Stephen M. Smith , Marie Claude Georges-Courbot , Chang Yong Lu
IPC分类号： A61K3800
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2740/15021 , C12N2740/15022
摘要： The nucleotide sequence and deduced amino acid sequences of the complete genome of a simian immunodeficiency virus isolate from a red-capped mangabey are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.
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9.发明授权Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 失效人类免疫缺陷病毒1型非亚型B分离株的参考克隆和序列公开(公告)号：US07169396B2
公开(公告)日：2007-01-30
申请号：US11135597
申请日：2005-05-23
申请人： Beatrice H. Hahn , George M. Shaw , Feng Gao
发明人： Beatrice H. Hahn , George M. Shaw , Feng Gao
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A01N63/00 , A01N63/04 , A61K8/22 , A61K8/602 , A61K8/66 , A61K2800/524 , A61Q5/00 , A61Q11/00 , A61Q17/005 , A61Q19/00 , C07H21/02 , C09D5/025 , C09D5/14 , C11D3/0078 , C11D3/2034 , C11D3/38654 , C11D3/48 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703 , A01N2300/00
摘要： The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.
摘要翻译： 公开了人类免疫缺陷病毒1型非亚型B分离株的11个分子克隆的基因组的核苷酸序列。 本发明涉及由这些序列编码和/或衍生自这些序列的核酸和肽及其在诊断方法中的用途和作为免疫原。
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10.发明授权Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 失效人类免疫缺陷病毒1型非亚型B分离株的参考克隆和序列公开(公告)号：US06492110B1
公开(公告)日：2002-12-10
申请号：US09184418
申请日：1998-11-02
申请人： Beatrice H. Hahn , George M. Shaw , Feng Gao
发明人： Beatrice H. Hahn , George M. Shaw , Feng Gao
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A01N63/00 , A01N63/04 , A61K8/22 , A61K8/602 , A61K8/66 , A61K2800/524 , A61Q5/00 , A61Q11/00 , A61Q17/005 , A61Q19/00 , C07H21/02 , C09D5/025 , C09D5/14 , C11D3/0078 , C11D3/2034 , C11D3/38654 , C11D3/48 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12Q1/703 , A01N2300/00
摘要： The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.
摘要翻译： 公开了人类免疫缺陷病毒1型非亚型B分离株的11个分子克隆的基因组的核苷酸序列。 本发明涉及由这些序列编码和/或衍生自这些序列的核酸和肽及其在诊断方法中的用途和作为免疫原。
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