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    Adjustable digital microscope display
    3.
    发明授权
    Adjustable digital microscope display 有权

    公开(公告)号：US09829696B2

    公开(公告)日：2017-11-28

    申请号：US14267735

    申请日：2014-05-01

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Zuo Cheng Shen ,  Daniel Y. Chu ,  Nicholas Doe ,  Emmanuel Quiroz

    IPC: H04N7/18 ,  G02B21/36 ,  G02B21/24

    CPC classification number: G02B21/368 ,  G02B21/241 ,  G02B21/365

    Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.

    Adjustable digital microscope display
    5.
    发明授权
    Adjustable digital microscope display 有权

    公开(公告)号：US10802264B2

    公开(公告)日：2020-10-13

    申请号：US15729503

    申请日：2017-10-10

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Zuo Cheng Shen ,  Daniel Y. Chu ,  Nicholas Doe ,  Emmanuel Quiroz ,  Amber Iraeta

    IPC: G02B21/36 ,  G02B21/24

    Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging.

    Compact automated cell counter
    8.
    发明授权
    Compact automated cell counter 有权

    公开(公告)号：US09850517B2

    公开(公告)日：2017-12-26

    申请号：US14039682

    申请日：2013-09-27

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Tom McCollum ,  Paul Patt ,  Frank Shen ,  Daniel Y. Chu ,  Don Flory ,  Mike Griffin ,  Xin Heng ,  Eli Hefner

    IPC: C12Q1/06 ,  G01N15/14 ,  G02B21/34 ,  G02B21/00

    CPC classification number: C12Q1/06 ,  G01N15/1434 ,  G02B21/0008 ,  G02B21/34

    Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

    OPTOFLUIDIC SORTER
    9.
    发明申请
    OPTOFLUIDIC SORTER 审中-公开

    公开(公告)号：US20170241888A1

    公开(公告)日：2017-08-24

    申请号：US15503369

    申请日：2015-08-19

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： Daniel Y. Chu ,  Paul J. Patt ,  Roger Tong

    IPC: G01N15/14 ,  C12Q1/04 ,  B01L3/00

    CPC classification number: G01N15/1404 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0424 ,  B01L2400/0454 ,  C12Q1/04 ,  G01N2015/1006 ,  G01N2015/1415

    Abstract: A method is provided for transporting a plurality of cells through a flow chamber, wherein the cells are initially immobilized on an internal surface of the flow chamber. The method comprises: selectively releasing the cells from the internal surface of the flow chamber; and flowing liquid through the flow chamber such that the released cells travel with the liquid, thereby transporting the cells through the flow chamber. Cells can be immobilized on or selectively released from the internal surface by applying or removing a trapping potential. The trapping potential can arise from an electric field gradient or an optical field gradient. Alternatively, cells can be selectively released from the surface using photocatalysis. Selective release allows cells to be individually observed or analyzed downstream, and can be based on a signal detected from one or more cells immobilized on the surface.

    Optofluidic sorter
    10.
    发明授权
    Optofluidic sorter 有权

    公开(公告)号：US10466156B2

    公开(公告)日：2019-11-05

    申请号：US15503369

    申请日：2015-08-19

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： Daniel Y. Chu ,  Paul J. Patt ,  Roger Tong

    IPC: G01N15/14 ,  B01L3/00 ,  C12Q1/04 ,  G01N15/10

    Abstract: A method is provided for transporting a plurality of cells through a flow chamber, wherein the cells are initially immobilized on an internal surface of the flow chamber. The method comprises: selectively releasing the cells from the internal surface of the flow chamber; and flowing liquid through the flow chamber such that the released cells travel with the liquid, thereby transporting the cells through the flow chamber. Cells can be immobilized on or selectively released from the internal surface by applying or removing a trapping potential. The trapping potential can arise from an electric field gradient or an optical field gradient. Alternatively, cells can be selectively released from the surface using photocatalysis. Selective release allows cells to be individually observed or analyzed downstream, and can be based on a signal detected from one or more cells immobilized on the surface.

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