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公开(公告)号：US20060211709A1
公开(公告)日：2006-09-21
申请号：US10513081
申请日：2003-05-02
申请人： Chris Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Co , Sergey Epshteyn , Abigail Kennedy , Baili Chen , Larisa Dubenko , Neel Anand , Tsze Tsang , John Nuss , Csabaj Peto , Kenneth Rice , Mohamed Ibrahim , Xian Shi , James Leahy , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Grace Mann , Larry Mann , Craig Takeuchi
发明人： Chris Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Co , Sergey Epshteyn , Abigail Kennedy , Baili Chen , Larisa Dubenko , Neel Anand , Tsze Tsang , John Nuss , Csabaj Peto , Kenneth Rice , Mohamed Ibrahim , Xian Shi , James Leahy , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Grace Mann , Larry Mann , Craig Takeuchi
IPC分类号： A61K31/497 , C07D403/02
CPC分类号： C07D241/26 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
摘要翻译： 公开了取代的芳基1,4-吡嗪衍生物及其在治疗焦虑症，抑郁症和应激相关疾病中的用途。
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公开(公告)号：US20060293342A1
公开(公告)日：2006-12-28
申请号：US10552424
申请日：2004-04-08
申请人： Jeff Chen , Lisa Dalrymple , Sergey Epshteyn , Timothy Forsyth , Tai Huynh , James Leahy , Brian Ridgway , Grace Mann , Larry Mann , Craig Takeuchi , Joan Sangalang
发明人： Jeff Chen , Lisa Dalrymple , Sergey Epshteyn , Timothy Forsyth , Tai Huynh , James Leahy , Brian Ridgway , Grace Mann , Larry Mann , Craig Takeuchi , Joan Sangalang
IPC分类号： A61K31/506 , A61K31/4439
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/506
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20070225307A1
公开(公告)日：2007-09-27
申请号：US11753462
申请日：2007-05-24
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/4704 , C07D401/02 , C07D403/02 , C07D417/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070244116A1
公开(公告)日：2007-10-18
申请号：US11753503
申请日：2007-05-24
申请人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/47 , A61K31/16 , A61K31/517 , C07C229/40 , C07D215/22 , C07D239/94 , C07D413/12 , C07D239/88 , C07C233/59 , A61K31/5355 , A61K31/196
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070054928A1
公开(公告)日：2007-03-08
申请号：US11586751
申请日：2006-10-26
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是c-Met，KDR，c-Kit，flt-3和flt-4，与细胞活性变化相关的信号转导途径的喹啉和喹啉 含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US20070275952A1
公开(公告)日：2007-11-29
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
发明人： Lynne Bannen , S. Brown , Wei Cheng , Vasu Jammalamadaka , John Nuss , Morrison Mac , Jason Parks , Matthew Williams , Wei Xu , Atwood Cheung , Lisa Dalrymple , Sergey Epshteyn , Mohamed Ibrahim , James Leahy , Gary Lewis , Robin Noguchi , Larry Mann , Brian Ridway , Joan Sangalang , Kevin Schnepp , Xian Shi , Richard Khoury
IPC分类号： A61K31/41 , A61K31/44 , A61K31/445 , A61K31/497 , A61K31/535 , A61K31/551 , A61P35/00 , C07D243/08 , C07D285/10 , C07D401/14 , C07D413/00 , C07D417/02 , C12N5/00 , C12Q1/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20060139757A1
公开(公告)日：2006-06-29
申请号：US11261172
申请日：2005-10-28
申请人： Michael Harris , Christopher Lee , Mike Ouyang , Larry Mann
发明人： Michael Harris , Christopher Lee , Mike Ouyang , Larry Mann
IPC分类号： G02B1/10
CPC分类号： G02B1/115
摘要： Generally, the invention is for a neutral color, anti-reflective coating for optical elements transmitting light in the visible range, said coating having a 3-layer or 4-layer structure comprising at least two coating materials selected from the group consisting of: (a) a coating material A having an index of refraction in the range of 1.35-1.5; (b) a coating material B having an index of refraction in the range of 1.9-2.4; and (c) a coating material C having an index of refraction in the range of 1.6-1.8. wherein said coating is placed on the first face or the second face, or both, of a substrate transmissive to light in the visible range. The invention is further directed to optical elements having the foregoing coatings.
摘要翻译： 通常，本发明涉及用于在可见光范围内透射光的光学元件的中性颜色抗反射涂层，所述涂层具有3层或4层结构，其包含至少两种选自以下的涂层材料：（ a）折射率在1.35-1.5范围内的涂层材料A; （b）折射率在1.9-2.4范围内的涂层材料B; 和（c）折射率在1.6-1.8范围内的涂层材料C. 其中所述涂层被放置在对可见光范围内的光透射的基板的第一面或第二面或两者上。 本发明还涉及具有上述涂层的光学元件。
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公开(公告)号：US20050128588A1
公开(公告)日：2005-06-16
申请号：US10971314
申请日：2004-10-22
IPC分类号： C03B23/037 , C03C4/00 , C03C14/00 , C03C15/00 , G02B5/30
CPC分类号： C03C4/00 , C03B23/037 , C03C14/006 , C03C15/00 , C03C2214/08 , G02B5/3033 , G02B5/3041 , G02B5/3058 , Y10S359/90
摘要： An ultra-thin polarizing glass article having two polarizing glass layers separated by a non-polarizing central region. The polarizing glass layers contain stretched or elongated metal particles and the non-polarizing central region contains elongated or stretched metal halide particle. The polarizing article has a thickness less than 200 micrometers.
摘要翻译： 具有由非偏振中心区域隔开的两个偏振玻璃层的超薄偏光玻璃制品。 偏振玻璃层含有拉伸的或细长的金属颗粒，非偏振中心区域包含细长或拉伸的金属卤化物颗粒。 偏光制品的厚度小于200微米。
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