公开(公告)号：US20160011082A1

公开(公告)日：2016-01-14

申请号：US14792038

申请日：2015-07-06

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Robert SPRINGER

IPC: G01N1/10

CPC classification number: G01N35/1079 ,  B01L3/50825 ,  G01N30/18

Abstract: A sample-taking unit having a sampling unit and a hold-down device which is movable relative thereto in a parallel manner, said sample-taking unit including a self-holding mechanism which, as a result of a self-locking effect, automatically fixes the hold-down device in a lowered fixing position against an upward movement until the self-locking effect is removed again as a result of the self-holding mechanism being acted upon with a detaching force, preferably as a result of contact between the sampling unit and a clamping element of the self-holding mechanism.

Abstract translation: 采样单元具有采样单元和可相对于其平行移动的压紧装置，所述取样单元包括自动保持机构，其作为自锁效果的结果自动固定 压紧装置处于降低的固定位置以防止向上运动，直到自锁效应由于自动保持机构被分离力而被去除，优选地由于采样单元之间的接触 以及自动保持机构的夹紧元件。

公开(公告)号：US20240280547A1

公开(公告)日：2024-08-22

申请号：US18653099

申请日：2024-05-02

Applicant: Dionex Softron GmbH

Inventor： Christoph HOLLNAGEL ,  Hermann HOCHGRAEBER ,  Thomas WACHINGER

IPC: G01N30/20 ,  G01N30/14 ,  G01N30/22 ,  G01N30/36

CPC classification number: G01N30/20 ,  G01N30/14 ,  G01N2030/201 ,  G01N2030/207 ,  G01N30/22 ,  G01N30/36

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

公开(公告)号：US20170248557A1

公开(公告)日：2017-08-31

申请号：US15596738

申请日：2017-05-16

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20210102922A1

公开(公告)日：2021-04-08

申请号：US17072997

申请日：2020-10-16

Applicant: Dionex Softron GmbH

Inventor： Christoph HOLLNAGEL ,  Hermann HOCHGRAEBER ,  Thomas WACHINGER

IPC: G01N30/20 ,  G01N30/14

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

公开(公告)号：US20190113484A1

公开(公告)日：2019-04-18

申请号：US16212914

申请日：2018-12-07

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N35/10 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20180272250A1

公开(公告)日：2018-09-27

申请号：US15991823

申请日：2018-05-29

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Thomas WACHINGER

IPC: B01D15/16 ,  G01N30/34

CPC classification number: B01D15/166 ,  G01N30/34

Abstract: The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0≤ΔGDV=GDVtarget−GDVactual≤Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.

公开(公告)号：US20150338000A1

公开(公告)日：2015-11-26

申请号：US14819743

申请日：2015-08-06

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER ,  Adolf SATZINGER

IPC: F16L21/04 ,  F16L19/00 ,  F16L21/035

CPC classification number: F16L21/04 ,  F16L19/00 ,  F16L19/061 ,  F16L21/035 ,  G01N30/6026 ,  G01N30/6039 ,  G01N30/6091

Abstract: A plug unit and system for connecting capillary tubes, especially for high-performance liquid chromatography, with a plug capillary tube projecting through a hole of a plug housing, which is detachably connectable to a bushing unit. The plug capillary tube front end projects into a capillary tube receptacle in the bushing unit with its end face essentially aligned opposite a front end of a bushing capillary tube or a bushing capillary tube opening of the bushing unit, the end face of which is butted against. The plug housing applies a force, with its end face facing the plug capillary tube end, directly or indirectly on an annular sealing element surrounding the plug capillary tube in the region of the front end of the plug capillary tube such that the front end of the plug capillary tube is sealed through deformation of the sealing element against the capillary tube receptacle opening.

Abstract translation: 一种插头单元和系统，用于连接毛细管，特别是用于高效液相色谱，其中插塞毛细管突出穿过插头壳体的孔，该插头毛细管可拆卸地连接到衬套单元。 塞子毛细管前端突出到衬套单元中的毛细管插座中，其端面基本上与衬套毛细管的前端或衬套单元的衬套毛细管开口相对准，衬套单元的端面与其对接 。 插头壳体将其端面面向塞子毛细管端部的力直接或间接地施加在塞子毛细管前端的区域周围的环形密封元件上，使得前端 插塞毛细管通过密封元件相对于毛细管插座开口的变形而被密封。

公开(公告)号：US20150226710A1

公开(公告)日：2015-08-13

申请号：US14618651

申请日：2015-02-10

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/16

CPC classification number: G01N30/16 ,  G01N30/18 ,  G01N30/24 ,  G01N2030/027

Abstract: The invention relates to a method for feeding a sample into an analysis branch of a liquid chromatography system, in particular a high-performance liquid chromatography system. A solvent or a solvent mixture from at least one solvent branch is supplied as volume flow {dot over (A)} into the analysis branch. At least one sample from at least one sample branch is fed as volume flow Ė into the analysis branch within a predetermined time interval. The volume flow {dot over (A)} is reduced to an extent during the predetermined time interval, and a volume flow Ċ resulting from the sum of the volume flows {dot over (A)} and Ė remains substantially constant in the analysis branch. The invention further relates to a sampler for carrying out a method of this kind.

Abstract translation: 本发明涉及一种将样品送入液相色谱系统的分析分支，特别是高效液相色谱系统中的方法。 将来自至少一个溶剂分支的溶剂或溶剂混合物作为体积流（点）（A）}供入分析分支。 来自至少一个样品分支的至少一个样品在预定时间间隔内作为体积流量进料到分析分支中。 在预定时间间隔内，体积流量（点数（A）}）减小到一定程度，并且由分析部分中的体积流量（点数（A）}和Ċ导致的体积流量Ė保持基本恒定 。 本发明还涉及一种用于执行这种方法的采样器。

公开(公告)号：US20240167985A1

公开(公告)日：2024-05-23

申请号：US18493974

申请日：2023-10-25

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N30/32 ,  G01N35/10

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/201 ,  G01N30/24

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20210199628A1

公开(公告)日：2021-07-01

申请号：US17199812

申请日：2021-03-12

Applicant: DIONEX SOFTRON GMBH

Inventor： Christoph HOLLNAGEL ,  Remco SWART ,  Hermann HOCHGRAEBER

IPC: G01N30/32 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22

Abstract: A method performed in a liquid chromatography system includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device, wherein the system is adapted to assume a configuration allowing the metering device to push a sample into the trap column and wherein the metering device is adapted to push the sample into the trap column in this configuration, wherein the system is adapted to assume a configuration allowing the sample to be sucked into the system by means of the metering device. Furthermore, the invention relates to a use of the liquid chromatography system for liquid chromatography, in particular of high-pressure liquid chromatography.