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公开(公告)号：US20180085743A1
公开(公告)日：2018-03-29
申请号：US15677526
申请日：2017-08-15
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC: B01J39/26 , B01D15/36 , B01D15/38 , B01J20/285 , B01J20/287 , B01J20/28 , B01J20/32 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , B01D15/32
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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公开(公告)号：US20150258540A1
公开(公告)日：2015-09-17
申请号：US14682456
申请日：2015-04-09
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
Abstract translation: 来自成形纤维的用于色谱的吸附介质，特别是离子交换层析。 在某些实施方案中，与普通纤维相比，官能化成形纤维呈现原纤化或脊状结构，其大大增加了纤维的表面积。 本文还公开了向高表面积纤维添加提供阳离子交换或阴离子交换官能团的表面侧基官能团的方法。 这种侧链官能团可用于生物分子的离子交换色谱纯化，如单克隆抗体（mAb）。
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公开(公告)号：US11305271B2
公开(公告)日：2022-04-19
申请号：US15677526
申请日：2017-08-15
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC: B01D15/36 , B01J20/28 , B01J47/12 , B01J39/26 , C12N7/02 , B01J47/014 , B01J47/127 , B01D15/38 , C07K1/18 , B01J41/20 , B01D15/32 , B01J20/285 , B01J20/287 , B01J20/32 , C07K16/00 , C12N7/00 , G01N30/52
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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公开(公告)号：US09815050B2
公开(公告)日：2017-11-14
申请号：US14682456
申请日：2015-04-09
Applicant: EMD Millipore Corporation
Inventor： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC: B01D15/36 , B01J20/28 , B01J47/12 , B01J39/26 , C12N7/02 , B01D15/32 , B01D15/38 , B01J20/285 , B01J20/287 , B01J20/32 , C07K1/18 , B01J41/20 , C07K16/00 , C12N7/00 , B01J47/014 , B01J47/127
CPC classification number: B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
Abstract: Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
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