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公开(公告)号：US07799822B2
公开(公告)日：2010-09-21
申请号：US11643622
申请日：2006-12-21
申请人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号： A01N43/36
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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公开(公告)号：US20080027067A1
公开(公告)日：2008-01-31
申请号：US11643622
申请日：2006-12-21
申请人： Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人： Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号： A61K31/495 , A61K31/426 , A61P29/00 , C07D401/00 , C07D403/00 , C07D277/02 , A61K31/445
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08163720B2
公开(公告)日：2012-04-24
申请号：US12844047
申请日：2010-07-27
申请人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A01N51/00 , A61N31/655
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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公开(公告)号：US20110082117A1
公开(公告)日：2011-04-07
申请号：US12844047
申请日：2010-07-27
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/635 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P25/00 , A61P13/00 , A61P17/00
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20120178713A1
公开(公告)日：2012-07-12
申请号：US13419936
申请日：2012-03-14
申请人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/496 , C07D403/12 , A61K31/506 , C07D417/14 , A61K31/501 , A61K31/454 , C07D471/04 , A61K31/437 , A61K31/427 , C07F7/02 , A61K31/695 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61P13/02 , C07D417/12
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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6.发明授权公开(公告)号：US08309587B2
公开(公告)日：2012-11-13
申请号：US13419936
申请日：2012-03-14
申请人： Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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7.发明申请公开(公告)号：US20130035310A1
公开(公告)日：2013-02-07
申请号：US13633478
申请日：2012-10-02
申请人： Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人： Esther Ann Martinborough , Lev Tyler Dewey Fanning , Urvi Jagdishbhai Sheth , Dean Mitchell Wilson , Andreas P. Termin , Timothy Donald Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号： A61K31/635 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/427 , A61K31/695 , A61P29/00 , A61P25/06 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/08 , A61P9/06 , A61P25/28 , A61P19/02 , A61P9/12 , A61P1/00 , A61K31/506
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to piperidine and piperazine phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的哌啶和哌嗪苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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公开(公告)号：US08802700B2
公开(公告)日：2014-08-12
申请号：US13492164
申请日：2012-06-08
申请人： Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
发明人： Urvi Sheth , Lev T. D. Fanning , Mehdi Numa , Hayley Binch , Dennis James Hurley , Jinglan Zhou , Sara S. Hadida Ruah , Anna R. Hazlewood , Alina Silina , Rajendran Vairagoundar , Fredrick F. Van Goor , Peter Diederik Jan Grootenhuis , Martyn C. Botfield
IPC分类号： A61K31/04 , A61K31/4725 , A61K31/4709
CPC分类号： A61K31/4725 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K2300/00
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08188283B2
公开(公告)日：2012-05-29
申请号：US12722642
申请日：2010-03-12
申请人： Hayley Binch , Peter D. J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
发明人： Hayley Binch , Peter D. J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
IPC分类号： C07K1/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08410132B2
公开(公告)日：2013-04-02
申请号：US13453193
申请日：2012-04-23
申请人： Hayley Binch , Peter D. J. Grootenhuis , Sara S Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
发明人： Hayley Binch , Peter D. J. Grootenhuis , Sara S Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
IPC分类号： A61K31/4375 , A61P3/10 , A61P5/18 , A61P11/00 , A61P25/16 , A61P25/28 , C07D471/04 , C12N5/00 , C07K1/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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