公开(公告)号：US12269920B2

公开(公告)日：2025-04-08

申请号：US17313506

申请日：2021-05-06

Applicant: Ethicon, Inc.

Inventor： Erman Senoz ,  Sasa Andjelic ,  Marc Brian Wisnudel

IPC: C08G63/78 ,  C08G63/08 ,  C08G63/64 ,  C08G63/82

Abstract: The present invention is directed to continuous reaction processes for preparing a glycolide/L-lactide copolymer formulation by continuously introducing glycolide monomer, L-lactide monomer, initiator and optionally a catalyst into at least one continuous reactor vessel under dry nitrogen environment, wherein the monomers, initiator, and optional catalyst are mixed at a first lower temperature and then transferred to a second continuous reactor operating at a second higher temperature, and then exothermally reacting and maintaining at a steady state, the blend of glycolide monomer, lactide monomer, initiator and optional catalyst to produce a PLGA copolymer reaction product.

公开(公告)号：US20220192662A1

公开(公告)日：2022-06-23

申请号：US17546386

申请日：2021-12-09

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Marc Wisnudel ,  Kenneth M. Keilman ,  Leo B. Kriksunov ,  Robert J. Tannhasuer

IPC: A61B17/06 ,  A61L17/12 ,  A61L17/04

Abstract: The present invention is directed to a length adaptive surgical suture comprising a monofilament or a braid of a plurality of filaments, the suture having an original length when implanted and a second length that is different from the original length within a first twenty-four (24) hour period of time after implantation to accommodate tissue swelling. The present invention is also directed to configurations and combinations that enable length adaptive results.

公开(公告)号：US20210002416A1

公开(公告)日：2021-01-07

申请号：US16458377

申请日：2019-07-01

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic

IPC: C08G63/08 ,  G01N25/48 ,  G01N25/14

Abstract: The present invention is directed to devices and methods for monitoring the purity of monomers, adjusting the polymerization conditions, and consequently improving a polymerization reaction process. In one method, monomer purity is estimated using an on-line evaluation by raising the temperature of the monomer formulation having a defined melting point to a first elevated temperature at least 20° C. above a preset melting point for a selected monomer formulation; cooling the monomer formulation at a controlled cooling rate in the range from about 0.5 to 50° C. per minute; measuring at least one critical property selected from the group consisting of a) crystallization peak temperature at the onset of crystallization, b) an area under the crystallization peak, which represents the heat or enthalpy of crystallization, ΔHc and combinations thereof, comparing the at least one of the selected critical properties measures relative to such properties for standard setting monomer formulations.

公开(公告)号：US09259514B2

公开(公告)日：2016-02-16

申请号：US14571371

申请日：2014-12-16

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Dennis D. Jamiolkowski ,  Brian M. Kelly ,  Christopher DeFelice ,  Daniel Steiger

IPC: C08G63/91 ,  A61L31/04 ,  A61L31/14 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61L17/12 ,  C08L67/04 ,  A61B17/064 ,  C08G65/32 ,  A61B17/00

CPC classification number: A61L31/041 ,  A61B17/064 ,  A61B17/0642 ,  A61B2017/00004 ,  A61B2017/00889 ,  A61B2017/00893 ,  A61L17/12 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  A61L31/148 ,  C08G63/664 ,  C08L67/04 ,  C08L2205/025 ,  C08L2205/03

Abstract: Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

Abstract translation: 公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。

公开(公告)号：US09173980B2

公开(公告)日：2015-11-03

申请号：US13842265

申请日：2013-03-15

Applicant: ETHICON, INC.

Inventor： Sasa Andjelic ,  Benjamin D. Fitz

IPC: C08L67/04 ,  A61L31/06 ,  A61L27/18 ,  C08L69/00 ,  C08L101/16 ,  D01D5/098 ,  D01F6/62 ,  D01F6/68 ,  D01F6/86 ,  B29D7/00 ,  D04H1/56 ,  A61L27/58 ,  A61L31/14 ,  B29C71/00

CPC classification number: A61L31/06 ,  A61L27/18 ,  A61L27/58 ,  A61L31/148 ,  B29C71/00 ,  B29D7/00 ,  C08L67/04 ,  C08L69/00 ,  C08L101/16 ,  C08L2203/02 ,  C08L2205/02 ,  D01D5/0985 ,  D01F6/625 ,  D01F6/68 ,  D01F6/86 ,  D04H1/56 ,  Y10T442/609 ,  C08L2666/18

Abstract: A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.

Abstract translation: 双峰生物可吸收聚合物组合物。 所述组合物包含第一量聚合以具有第一分子量分布的生物可吸收聚合物; 所述第二量的所述生物可吸收聚合物被聚合以具有重均分子量在约10,000至约50,000道尔顿之间的第二分子量分布，所述第一分子量分布与所述第二分子量分布的重均分子量比为 至少约二比一; 其中所述第一和第二量的所述生物可吸收聚合物的基本均匀的共混物以约50/50至约95/5重量/重量％的比例形成。 还公开了医疗装置，制造医疗装置的方法和熔融吹制半结晶聚合物共混物的方法。

公开(公告)号：US20140187726A1

公开(公告)日：2014-07-03

申请号：US14176232

申请日：2014-02-10

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Dennis D. Jamiolkowski

IPC: C08G63/08 ,  C08G63/91

CPC classification number: C08G63/08 ,  A61L17/12 ,  A61L27/18 ,  A61L27/58 ,  C08G63/912

Abstract: Novel semi-crystalline, segmented copolymers of lactide and epsilon-caprolactone exhibiting long term absorption characteristics are disclosed. The novel polymer compositions are useful for long term absorbable meshes, surgical sutures, especially monofilament sutures, and other medical devices.

Abstract translation: 公开了具有长期吸收特性的丙交酯和ε-己内酯的新型半结晶分段共聚物。 新型聚合物组合物可用于长期可吸收网眼，手术缝合线，特别是单丝缝合线和其它医疗装置。

公开(公告)号：US08552142B2

公开(公告)日：2013-10-08

申请号：US13630062

申请日：2012-09-28

Applicant: Ethicon, Inc.

Inventor： Modesto Erneta ,  Dennis D. Jamiolkowski ,  Jianguo J. Zhou ,  Sasa Andjelic

IPC: C08G63/08

CPC classification number: C08G63/08 ,  B29C47/0014 ,  B29C47/385 ,  B29C47/6087 ,  B29C47/889 ,  B29C2947/92514 ,  B29C2947/9259 ,  B29C2947/92704 ,  B29C2947/92885 ,  B29C2947/92895 ,  B29C2947/92904 ,  D04H1/56 ,  D04H3/02 ,  D04H3/16 ,  Y10T442/68

Abstract: Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.

Abstract translation: 表现出以下组合性质的共聚物，包括但不限于ε-己内酯，其量为约12至约70摩尔％，乙交酯的量为约30至约88摩尔％，结晶度为约10至约50 ％，通过DSC测量为约10至约50J / g，并且在25℃下在0.1g / dl HFIP溶液中测量的特性粘度范围为约0.5至约1.45dL / g。 本文描述了熔融吹制由此产生的共聚物和非织造构造物的方法。

公开(公告)号：US20230141333A1

公开(公告)日：2023-05-11

申请号：US17520963

申请日：2021-11-08

Applicant: Ethicon, Inc.

Inventor： Sasa Andjelic ,  Leo B. Kriksunov

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/6883 ,  A61B5/14539 ,  A61B5/14735 ,  A61B2017/00004

Abstract: The present invention is directed to an implantable medical device, comprising: a device body, with at least a portion of said body coated by a sensing coating that comprises an echogenic material or a radiopaque material, or combinations thereof, said sensing coating configured to dissolve or swell in presence of at least one infection biomarker; wherein a portion of said sensing coating is covered by a protective film, forming a protected portion, said protected portion configured not to dissolve or swell in presence of said biomarker and methods of detecting presence of biomarkers in the vicinity of an implanted medical device.

公开(公告)号：US20210355273A1

公开(公告)日：2021-11-18

申请号：US17313506

申请日：2021-05-06

Applicant: Ethicon, Inc.

Inventor： Erman Senoz ,  Sasa Andjelic ,  Marc Brian Wisnudel

IPC: C08G63/78 ,  C08G63/64

Abstract: The present invention is directed to continuous reaction processes for preparing a glycolide/L-lactide copolymer formulation by continuously introducing glycolide monomer, L-lactide monomer, initiator and optionally a catalyst into at least one continuous reactor vessel under dry nitrogen environment, wherein the monomers, initiator, and optional catalyst are mixed at a first lower temperature and then transferred to a second continuous reactor operating at a second higher temperature, and then exothermally reacting and maintaining at a steady state, the blend of glycolide monomer, lactide monomer, initiator and optional catalyst to produce a PLGA copolymer reaction product.

公开(公告)号：US20210322624A1

公开(公告)日：2021-10-21

申请号：US17349535

申请日：2021-06-16

Applicant: Ethicon, Inc.

Inventor： Dennis D. Jamiolkowski ,  Christopher DeFelice ,  Sasa Andjelic ,  Brian M. Kelly ,  Marc Wisnudel ,  Daniel Steiger ,  Gaoyuan Gavin Chen

IPC: A61L17/12 ,  A61L17/00 ,  A61L17/14 ,  C08G63/64 ,  A61B17/06

Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.