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公开(公告)号：US5543431A
公开(公告)日：1996-08-06
申请号：US449622
申请日：1995-05-24
申请人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号： C07D207/12 , C07C233/09 , A61K31/16 , A61K31/695 , C07C233/20
CPC分类号： C07D207/12
摘要： A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
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公开(公告)号：US5461071A
公开(公告)日：1995-10-24
申请号：US326986
申请日：1994-10-21
申请人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人： Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号： C07D207/12 , A61K31/40 , A61K31/445 , C07D211/40
CPC分类号： C07D207/12
摘要： A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
摘要翻译： 描述了具有抗真菌剂的式“IMAGE”的化合物。 还描述了生产菌Colletotricum accutatum以及生产方法。
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3.发明授权Antifungal agent produced by arthrinium arundinis ATCC 74359 失效由arthrinium arundinis ATCC 74359生产的抗真菌剂
公开(公告)号：US5712109A
公开(公告)日：1998-01-27
申请号：US789348
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
CPC分类号： C07J9/00
摘要： There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
摘要翻译： 公开了由真菌Arthrinium arundinis ATCC 74359产生的具有式（I）的化合物，并表现出抗真菌活性。
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公开(公告)号：US5756472A
公开(公告)日：1998-05-26
申请号：US789349
申请日：1997-01-27
申请人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人： Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号： C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号： C07H15/24 , Y10S435/911
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。
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公开(公告)号：US5348970A
公开(公告)日：1994-09-20
申请号：US125432
申请日：1993-09-22
申请人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
发明人： Robert E. Schwartz , Janet C. Onishi , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez , Maria T. Diez , Francisca Vicente , Julian Gorrochategui , Gregory L. Helms , Barnali Pramanik
IPC分类号： C07D405/06 , A61K31/40
CPC分类号： C07D405/06
摘要： A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.
摘要翻译： 通过真菌分离物ATCC号的发酵产生式1化合物：
1。 生物体包括在本文中，以及生产化合物的方法，药物组合物和治疗方法。 -
6.发明授权Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control 失效Rosellinia subiculata ATCC 74386和真菌ATCC 74387，用于生产用于真菌控制的sordarin化合物公开(公告)号：US06436395B1
公开(公告)日：2002-08-20
申请号：US09269004
申请日：1999-06-23
申请人： Gerald F. Bills , Anne W. Dombrowski , Wendy S. Horn , Richard K. Jansson , Mark Rattray , Dennis Schmatz , Robert E. Schwartz
发明人： Gerald F. Bills , Anne W. Dombrowski , Wendy S. Horn , Richard K. Jansson , Mark Rattray , Dennis Schmatz , Robert E. Schwartz
IPC分类号： A01N6300
CPC分类号： C07H15/18 , A01N45/00 , A01N63/04 , C12N1/14 , C12P17/06 , C12P17/185 , C12P19/56 , Y10S435/911
摘要： Disclosed is a method for controlling phytopathogenic fungi using pure strains of Rosellinia subiculata ATCC 74386 and fungus ATCC 74387. Further, methods of producing a sordarin compound are disclosed. The method includes cultivating each strain separately in a nutrient medium containing assimilable sources of carbon and nitrogen and recovering the compound. A sordarin compound of formula I is also disclosed. Also an antifungal composition containing a sordarin compound is also disclosed.
摘要翻译： 公开了一种使用纯化的Rosellinia subiculata ATCC 74386和真菌ATCC 74387的菌株来控制植物病原真菌的方法。此外，公开了生产桑德林化合物的方法。 该方法包括在含有可同化碳源和氮源的营养培养基中分别培养各菌株并回收该化合物。 还公开了式I的索尔定化合物。 还公开了含有索尔纳林化合物的抗真菌组合物。
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公开(公告)号：US4806565A
公开(公告)日：1989-02-21
申请号：US53920
申请日：1987-05-26
申请人： Otto D. Hensens , August J. Kempf , Robert E. Schwartz , Ruth S. Sykes , Carol F. Wichmann , Kenneth E. Wilson , Sheldon B. Zimmerman , Deborah L. Zink
发明人： Otto D. Hensens , August J. Kempf , Robert E. Schwartz , Ruth S. Sykes , Carol F. Wichmann , Kenneth E. Wilson , Sheldon B. Zimmerman , Deborah L. Zink
IPC分类号： A61K31/335 , A01N43/28 , A61K31/357 , A61P31/04 , A61P31/10 , C07D317/34 , C07D317/36 , C07D317/30
CPC分类号： C07D317/36 , A01N43/28
摘要： The invention relates to a novel tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 OR ATCC-53616. The tri-yne carbonate has antifungal activity.
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公开(公告)号：US4931352A
公开(公告)日：1990-06-05
申请号：US362647
申请日：1989-06-07
申请人： Robert A. Fromtling , Robert A. Giacobbe , Jerrold M. Liesch , Sagrario M. Del Val , Robert E. Schwartz , Carol F. Wichmann
发明人： Robert A. Fromtling , Robert A. Giacobbe , Jerrold M. Liesch , Sagrario M. Del Val , Robert E. Schwartz , Carol F. Wichmann
摘要： An antifungal agent produced by cultivation of a yet unidentified microorganism is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
摘要翻译： 通过培养未鉴定的微生物产生的抗真菌剂是对人类病原体具有非常高的活性和非常低的哺乳动物毒性的环状脂肽。 还描述了其生产和分离。
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公开(公告)号：US4968608A
公开(公告)日：1990-11-06
申请号：US105797
申请日：1987-10-07
IPC分类号： C12P21/02 , A61K31/40 , A61K38/00 , A61P31/04 , A61P31/10 , C07D487/14 , C07K7/56 , C12P21/04 , C12R1/645
CPC分类号： C12R1/645 , C07K7/56 , A61K38/00 , Y10S435/911
摘要： An antifungal agent produced by cultivation of Zalerion arboricola is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.
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公开(公告)号：US5386009A
公开(公告)日：1995-01-31
申请号：US495200
申请日：1990-03-19
摘要： The present invention is directed to water-soluble derivatives of antibiotic lipopeptides. The derivatives have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.
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