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公开(公告)号:US5543431A
公开(公告)日:1996-08-06
申请号:US449622
申请日:1995-05-24
申请人: Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人: Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vicente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号: C07D207/12 , C07C233/09 , A61K31/16 , A61K31/695 , C07C233/20
CPC分类号: C07D207/12
摘要: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
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公开(公告)号:US5461071A
公开(公告)日:1995-10-24
申请号:US326986
申请日:1994-10-21
申请人: Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
发明人: Evon A. Bolessa , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Fernando Pelaez Perez , Angeles Cabello Arroyo , Teresa Diez Matas , Isabel Martin Fernandez , Francisca Vincente Perez , Suzanne M. Mandala , Deborah L. Zink , Rosemary Thornton , John R. Thompson , James E. Curotto
IPC分类号: C07D207/12 , A61K31/40 , A61K31/445 , C07D211/40
CPC分类号: C07D207/12
摘要: A compound having the formula ##STR1## which is an anti-fungal agent is described. The producing organism Colletotricum accutatum is also described, along with a method of production.
摘要翻译: 描述了具有抗真菌剂的式“IMAGE”的化合物。 还描述了生产菌Colletotricum accutatum以及生产方法。
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公开(公告)号:US5686637A
公开(公告)日:1997-11-11
申请号:US371171
申请日:1995-01-10
申请人: Gerald F. Bills , James E. Curotto , S. Dreikorn , Robert A. Giacobbe , Guy H. Harris , Suzanne Miller Mandala , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello Arroyo , Fernando Pelaez Perez , Teresa Diez Matas , Francisca Vicente Perez
发明人: Gerald F. Bills , James E. Curotto , S. Dreikorn , Robert A. Giacobbe , Guy H. Harris , Suzanne Miller Mandala , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello Arroyo , Fernando Pelaez Perez , Teresa Diez Matas , Francisca Vicente Perez
IPC分类号: C07C69/738 , C12P7/64 , C07C59/147
CPC分类号: C12P7/6463 , C07C69/738
摘要: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译: 公开了具有抗真菌活性的具有式(I)< IMAGE>的式的新化合物。
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公开(公告)号:US5712151A
公开(公告)日:1998-01-27
申请号:US734702
申请日:1996-10-21
申请人: Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
发明人: Sandra A. Morris , Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Angela Basilio , Maria Teresa Diez , Fernando Pelaez , Francisca Vicente , Bruce W. Burgess , Stanley L. Streicher , Deborah L. Zink , John R. Thompson
IPC分类号: A01N37/42 , C07D207/44 , C07D207/448 , C12P17/10 , C12N5/00 , C12N5/02
CPC分类号: C07D207/448 , A01N37/42 , C12P17/10 , C12R1/645
摘要: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译: 公开了具有抗真菌活性的具有式(I)的化合物。
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公开(公告)号:US5756472A
公开(公告)日:1998-05-26
申请号:US789349
申请日:1997-01-27
申请人: Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人: Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Sandra A. Morris , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Wendy S. Horn , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
IPC分类号: C07H15/24 , A61K31/70 , C07D315/00 , C12N1/14
CPC分类号: C07H15/24 , Y10S435/911
摘要: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译: 公开了具有抗真菌活性的具有式(I)< IMAGE>的式的新化合物。
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6.Antifungal agent produced by arthrinium arundinis ATCC 74359 失效
标题翻译: 由arthrinium arundinis ATCC 74359生产的抗真菌剂公开(公告)号:US5712109A
公开(公告)日:1998-01-27
申请号:US789348
申请日:1997-01-27
申请人: Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
发明人: Jerrold M. Liesch , Maria S. Meinz , Janet C. Onishi , Robert E. Schwartz , Gerald F. Bills , Robert A. Giacobbe , Deborah L. Zink , Angeles Cabello , Maria T. Diez , Isabella Martin , Fernando Pelaez , Francisca Vicente
CPC分类号: C07J9/00
摘要: There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.
摘要翻译: 公开了由真菌Arthrinium arundinis ATCC 74359产生的具有式(I)的化合物,并表现出抗真菌活性。
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公开(公告)号:US5543429A
公开(公告)日:1996-08-06
申请号:US401385
申请日:1995-03-09
申请人: Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Rosalind G. Jenkins , Jerrold M. Liesch , Sandra A. Morris , John R. Thompson , Deborah L. Zink , Richard K. Jansson , Angela Basilio , Teresa Diez , Fernando Pelaez , Francisca Vicente
发明人: Gerald F. Bills , James E. Curotto , Sarah J. Dreikorn , Rosalind G. Jenkins , Jerrold M. Liesch , Sandra A. Morris , John R. Thompson , Deborah L. Zink , Richard K. Jansson , Angela Basilio , Teresa Diez , Fernando Pelaez , Francisca Vicente
IPC分类号: C07D307/77 , A61K31/34
CPC分类号: C07D307/77
摘要: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
摘要翻译: 公开了具有抗真菌活性的具有式(I)和(IMA)(II)的式的新化合物。
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公开(公告)号:US5702929A
公开(公告)日:1997-12-30
申请号:US734704
申请日:1996-10-21
申请人: Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Stanley L. Streicher , Deborah L. Zink , John R. Thompson , Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente
发明人: Sandra A. Morris , James E. Curotto , Gerald F. Bills , Sarah J. Dreikorn , Stanley L. Streicher , Deborah L. Zink , John R. Thompson , Angela Basilio , Fernando Pelaez , Maria Teresa Diez , Francisca Vicente
IPC分类号: C07D405/06 , C12P17/16 , C12N5/00 , C07D207/00
CPC分类号: C07D405/06 , C12P17/16
摘要: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译: 公开了具有抗真菌活性的具有式(I)的化合物。
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公开(公告)号:US5597806A
公开(公告)日:1997-01-28
申请号:US437718
申请日:1995-05-09
申请人: Wendy H. Clapp , Guy H. Harris , Gerald F. Bills , James E. Curotto , Anne W. Dombrowski , Sarah J. Driekorn , Myra B. Kurtz , Maria S. Meinz , Janet C. Onishi , Jon D. Polishook , Stanley L. Streicher , John R. Thompson , Marie Williams , Deborah L. Zink
发明人: Wendy H. Clapp , Guy H. Harris , Gerald F. Bills , James E. Curotto , Anne W. Dombrowski , Sarah J. Driekorn , Myra B. Kurtz , Maria S. Meinz , Janet C. Onishi , Jon D. Polishook , Stanley L. Streicher , John R. Thompson , Marie Williams , Deborah L. Zink
IPC分类号: C07H15/256 , C07J17/00 , C12P19/56 , A61K31/71 , C07J19/00
CPC分类号: C07J17/005 , C07H15/256 , C12P19/56 , Y10S435/822
摘要: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
摘要翻译: 公开了具有抗真菌活性的具有式(I)和(IMA)(II)的式的新化合物。
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公开(公告)号:US06403347B1
公开(公告)日:2002-06-11
申请号:US09355692
申请日:1999-10-25
申请人: Gerald F. Bills , Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink , Fernando Pelaez , Ana M. Teran
发明人: Gerald F. Bills , Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink , Fernando Pelaez , Ana M. Teran
IPC分类号: A61K3135
CPC分类号: A61K31/35
摘要: Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译: 描述了天然产物,如某些chaetochromins。 这些化合物可用作抑制HIV整合酶,预防或治疗HIV感染和治疗AIDS,作为化合物,药学上可接受的盐,药物组合物成分,无论是否与其他抗病毒药,免疫调节剂,抗生素或其他抗生素组合使用 疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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