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公开(公告)号：US11708589B2
公开(公告)日：2023-07-25
申请号：US16894600
申请日：2020-06-05
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Jun Sun , Priti Pharkya
Abstract: Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
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2.发明授权公开(公告)号：US10669561B2
公开(公告)日：2020-06-02
申请号：US15323360
申请日：2015-07-02
Applicant: Genomatica, Inc.
Inventor： Stephanie J. Culler , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
IPC: C12N15/00 , C12N1/20 , C12N9/00 , C12N9/02 , C12N9/88 , C12N9/90 , C07H21/04 , C12P7/04 , C12N15/52 , C12P5/02 , C12P7/40 , C12N9/04
Abstract: The invention provides a non-naturally occurring microbial organism having a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol, pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a pathway. The invention additionally provides a method for producing butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol. The method can include culturing a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a pathway enzyme in a sufficient amount, and under conditions and for a sufficient period of time to produce butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol.
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公开(公告)号：US20190152887A1
公开(公告)日：2019-05-23
申请号：US16110973
申请日：2018-08-23
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Priti Pharkya , Stephen J. Van Dien , Anthony P. Burgard , Christophe H. Schilling
IPC: C07C51/353 , C07C67/32 , C12P7/62 , C12P7/46 , C07C67/333 , C12P7/40 , C07C57/04 , C07C51/38 , C07C67/08
Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.
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公开(公告)号：US20190085363A1
公开(公告)日：2019-03-21
申请号：US15960410
申请日：2018-04-23
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Jun Sun , Priti Pharkya
Abstract: Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
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公开(公告)号：US20190048366A1
公开(公告)日：2019-02-14
申请号：US15917411
申请日：2018-03-09
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
IPC: C12P5/02 , C07C1/24 , C12P7/04 , C12N15/52 , C07C11/167
Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
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Patent Agency Ranking
公开(公告)号：US20170369913A1
公开(公告)日：2017-12-28
申请号：US15538448
申请日：2015-12-22
Applicant: Genomatica, Inc.
Inventor： Lauri H. Suominen , Connor J. Galleher , Michael Japs , Mark J. Burk , Cara Tracewell
Abstract: Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.
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7.发明申请公开(公告)号：US20170166931A1
公开(公告)日：2017-06-15
申请号：US15323360
申请日：2015-07-02
Applicant: Genomatica, Inc.
Inventor： Stephanie J. Culler , Mark J. Burk , Robin E. Osterhout , Priti Pharkya
Abstract: The invention provides a non-naturally occurring microbial organism having a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol, pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a pathway. The invention additionally provides a method for producing butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol. The method can include culturing a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a pathway enzyme in a sufficient amount, and under conditions and for a sufficient period of time to produce butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol.
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8.发明授权Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene 有权用于生物合成芳烃，2,4-戊二烯酸和1,3-丁二烯的微生物和方法公开(公告)号：US09556461B2
公开(公告)日：2017-01-31
申请号：US14226631
申请日：2014-03-26
Applicant: Genomatica, Inc.
Inventor： Robin E. Osterhout , Anthony P. Burgard , Priti Pharkya , Mark J. Burk
IPC: C12N1/00 , C12N1/26 , C12N9/10 , C12P7/00 , C12P7/62 , C12N15/52 , C12P5/00 , C12P5/02 , C12P7/16 , C12P7/40 , C12P9/00 , A61K38/00
CPC classification number: C12P7/62 , C12N15/52 , C12P5/005 , C12P5/026 , C12P7/16 , C12P7/40 , C12P9/00 , Y02E50/10
Abstract: The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene.
Abstract translation: 本发明提供了具有甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯 ，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯途径。 本发明另外提供了使用这些生物体来生产甲苯，苯，对甲苯甲酸酯，对苯二甲酸酯，（2-羟基-3-甲基-4-氧代丁氧基）膦酸酯，（2-羟基-4-氧代丁氧基）膦酸酯，苯甲酸酯，苯乙烯 ，2,4-戊二烯酸酯，3-丁烯-1醇或1,3-丁二烯。
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公开(公告)号：US20170008828A1
公开(公告)日：2017-01-12
申请号：US15182245
申请日：2016-06-14
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Priti Pharkya , Stephen J. Van Dien , Anthony P. Burgard , Christophe H. Schilling
IPC: C07C51/353 , C12P7/46 , C12P7/62 , C07C67/08
CPC classification number: C07C51/353 , C07C51/38 , C07C57/04 , C07C67/08 , C07C67/32 , C07C67/333 , C12P7/40 , C12P7/46 , C12P7/62 , Y02P20/125 , C07C69/60 , C07C69/54
Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.
Abstract translation: 本发明提供了制备丙烯酸的方法。 该方法包括在交叉复分解转化催化剂存在下使富马酸与足够量的乙烯接触，以产生约2摩尔丙烯酸/摩尔富马酸。 还提供了丙烯酸酯。 该方法包括在交叉复分解转化催化剂存在下使富马酸二酯与足够量的乙烯接触，以产生每摩尔富马酸二酯约2摩尔丙烯酸酯。 提供了用于生产丙烯酸或丙烯酸酯的方法的综合方法，其将富马酸的生物生产与易位转化相结合。 还提供丙烯酸和丙烯酸酯生产。
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10.发明授权公开(公告)号：US09458480B2
公开(公告)日：2016-10-04
申请号：US13730612
申请日：2012-12-28
Applicant: GENOMATICA, INC.
Inventor： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya
IPC: C08G69/10 , C12P17/12 , C12P13/00 , C12N1/00 , C12N1/20 , C08G69/26 , C08G73/00 , C07C205/00 , C07C211/00 , C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/02 , C12P17/10
CPC classification number: C12P17/10 , C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/12
Abstract: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.
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