公开(公告)号：US10174038B2

公开(公告)日：2019-01-08

申请号：US15618974

申请日：2017-06-09

Applicant: Gilead Sciences, Inc.

Inventor： Hon Chung Hui ,  Jay P. Parrish ,  Michael Sangi ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: A61K31/397 ,  C07D487/04 ,  C07D519/00 ,  C07D471/04 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377

Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20180311263A1

公开(公告)日：2018-11-01

申请号：US15902690

申请日：2018-02-22

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/53 ,  A61K31/00 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K45/06 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/706 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US09724360B2

公开(公告)日：2017-08-08

申请号：US14926062

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07H15/18 ,  C07H7/06 ,  A61K31/685 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20170190708A1

公开(公告)日：2017-07-06

申请号：US15347494

申请日：2016-11-09

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Constantine G. Boojamra ,  Eugene J. Eisenberg ,  Hon Chung Hui ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Oliver L. Saunders ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20140051656A1

公开(公告)日：2014-02-20

申请号：US13956195

申请日：2013-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Hongyan Guo ,  Darryl Kato ,  Thorsten A. Kirschberg ,  Hongtao Liu ,  John O. Link ,  Michael L. Mitchell ,  Jay P. Parrish ,  Jianyu Sun ,  James Taylor ,  Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Choung U. Kim ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Randall L. Halcomb ,  Michael Graupe ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  Qi Liu ,  Richard L. Mackman ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  Scott D. Schroeder ,  William J. Watkins ,  Lianhong Xu

IPC: C07D403/14 ,  A61K45/06 ,  A61K31/4184

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130164280A1

公开(公告)日：2013-06-27

申请号：US13722962

申请日：2012-12-20

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Hon Chung Hui ,  Petr Jansa ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: A61K45/06 ,  A61K31/519 ,  A61K31/675 ,  A61K31/538 ,  C07F9/6561 ,  C07D487/04 ,  C07D487/08

CPC classification number: A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D487/08 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

公开(公告)号：US20170362244A1

公开(公告)日：2017-12-21

申请号：US15639970

申请日：2017-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Kerim Babaoglu ,  Constantine G. Boojamra ,  Eugene J. Eisenberg ,  Hon Chung Hui ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Oliver L. Saunders ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  C07D513/04 ,  C07D495/04 ,  A61K45/06 ,  A61K31/675 ,  A61K31/551 ,  A61K31/55 ,  A61K31/5377 ,  C07F9/6561 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20150166546A1

公开(公告)日：2015-06-18

申请号：US14566340

申请日：2014-12-10

Applicant: Gilead Sciences, Inc.

Inventor： Constantine G. Boojamra ,  Hon Chung Hui ,  Petr Jansa ,  Richard L. Mackman ,  Jay P. Parrish ,  Michael Sangi ,  Dustin Siegel ,  David Sperandio ,  Hai Yang

IPC: C07D487/04

CPC classification number: A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/675 ,  A61K45/06 ,  C07D487/04 ,  C07D487/08 ,  C07D519/00 ,  C07F9/6561

Abstract: The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

Abstract translation: 本发明提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯及其组合物。 化合物和组合物可用于治疗肺炎链球菌病毒感染，包括人呼吸道合胞病毒感染。

公开(公告)号：US20130273037A1

公开(公告)日：2013-10-17

申请号：US13865069

申请日：2013-04-17

Applicant: GILEAD SCIENCES, INC.

Inventor： Dustin Siegel ,  David Sperandio ,  Hai Yang ,  Michael Sangi ,  Jay P. Parrish ,  Hon Chung Hui

IPC: C07D487/04 ,  C07D471/04 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/4545 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：US20230125751A1

公开(公告)日：2023-04-27

申请号：US17854818

申请日：2022-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.