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公开(公告)号：US12264173B2
公开(公告)日：2025-04-01
申请号：US18354362
申请日：2023-07-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC: A61P31/14 , A61K31/661 , A61K31/675 , A61P31/12 , C07F9/6561
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US12030903B2
公开(公告)日：2024-07-09
申请号：US17178115
申请日：2021-02-17
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Michael O. Clarke , Bindu Goyal , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel
IPC: C07F9/6561 , A61K45/06
CPC classification number: C07F9/6561 , A61K45/06
Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.
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公开(公告)号：US20230303599A1
公开(公告)日：2023-09-28
申请号：US18040782
申请日：2021-08-05
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Byoung-Kwon Chun , Michael O. Clarke , Petr Jansa , Devan Naduthambi , Neil H. Squires
IPC: C07F9/6561 , A61K45/06 , A61P31/18 , A61P31/20
CPC classification number: C07F9/65616 , A61K45/06 , A61P31/18 , A61P31/20
Abstract: Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed. In particular, prodrugs of phosphonamide nucleotide analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.
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公开(公告)号：US12110305B2
公开(公告)日：2024-10-08
申请号：US17394630
申请日：2021-08-05
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Byoung-Kwon Chun , Michael O. Clarke , Petr Jansa , Devan Naduthambi , Neil H. Squires
IPC: C07F9/36 , A61K45/06 , A61P31/18 , A61P31/20 , C07F9/6561
CPC classification number: C07F9/36 , A61K45/06 , A61P31/18 , A61P31/20 , C07F9/65616
Abstract: Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed. In particular, prodrugs of phosphonamide nucleotide analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.
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公开(公告)号：US11767337B2
公开(公告)日：2023-09-26
申请号：US17178463
申请日：2021-02-18
Applicant: Gilead Sciences, Inc.
Inventor： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC: C07F9/6561 , A61P31/14
CPC classification number: C07F9/6561 , A61P31/14
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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Patent Agency Ranking
公开(公告)号：US20230295201A1
公开(公告)日：2023-09-21
申请号：US18171950
申请日：2023-02-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Byoung-kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel , David Sperandio , Hai Yang , Lijun Zhang
IPC: C07F9/6561 , A61K31/706
CPC classification number: C07F9/6561 , A61K31/706
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US20230212199A1
公开(公告)日：2023-07-06
申请号：US17820183
申请日：2022-08-16
Applicant: Gilead Sciences, Inc.
Inventor： Byoung-Kwon Chun , Michael O. Clarke , Deeba Ensan , Rao V. Kalla , Richard L. Mackman , Jagadeesh N. Manda , Devan Naduthambi , Dustin S. Siegel
Abstract: Phospholipid compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical formulations of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20230040586A1
公开(公告)日：2023-02-09
申请号：US17355813
申请日：2021-06-23
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Byoung-Kwon Chun , Michael O. Clarke , Petr Jansa , Rao V. Kalla , Dmitry Koltun , Richard L. Mackman , Thao D. Perry , Dustin S. Siegel , Scott P. Simonovich
IPC: C07F9/6561 , A61K45/06
Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20220363708A1
公开(公告)日：2022-11-17
申请号：US17207161
申请日：2021-03-19
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Byoung-Kwon Chun , Michael O. Clarke , Petr Jansa , Richard L. Mackman , Devan Naduthambi , Neil H. Squires
IPC: C07H19/16 , C07H19/20 , A61K31/7076 , A61P31/18 , A61K45/06
Abstract: The present disclosure provides prodrugs of 4′-C-substituted-2-halo-2′-deoxyadenoside nucleosides, and compositions, methods, and kits thereof. Such compounds can be useful for treating viral infections including, but not limited to, human immunodeficiency virus.
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公开(公告)号：US20250127801A1
公开(公告)日：2025-04-24
申请号：US18911325
申请日：2024-10-10
Applicant: Gilead Sciences, Inc.
Inventor： Megan K. Armstrong , Chienhung Chou , Michael O. Clarke , Ana Z. Gonzalez Buenrostro , Xiaochun Han , Lan Jiang , Jiayao Li , Gregg M. Schwarzwalder , Qiaoyin Wu , Hai Yang
IPC: A61K31/675 , A61K31/55 , A61K45/06 , A61P31/18 , C07D519/00 , C07F9/6561
Abstract: The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
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