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公开(公告)号：US08592220B2
公开(公告)日：2013-11-26
申请号：US12447143
申请日：2007-10-26
申请人： H. Sam Bergh , Jason Wells , Victor Wong , John Gallipeo , Lynn Van Erden , Anthony F. Volpe , Jeffrey Maag
发明人： H. Sam Bergh , Jason Wells , Victor Wong , John Gallipeo , Lynn Van Erden , Anthony F. Volpe , Jeffrey Maag
IPC分类号： G01N1/10
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00389 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00601 , B01J2219/00689 , B01J2219/00704 , B01J2219/00736 , B01J2219/00747 , C40B60/12
摘要： The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
摘要翻译： 本发明公开了一种用于快速分析组合图书馆成员的装置和方法。 该装置包括用于容纳单个文件库构件的多个反应堆容器，在每个容器之间大致相等地分配测试流体的流体处理系统和用于封闭反应堆容器的壳体，壳体限定压力室，其中壳体 被配置为维持基本上高于大气压的压力。 这允许通过在反应器组件上提供小的压差同时筛选高压力下的文库构件。 基于它们催化流体反应物转化的能力，所公开的装置对于筛选文库成员特别有用。
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公开(公告)号：US20100144539A1
公开(公告)日：2010-06-10
申请号：US12447143
申请日：2007-10-26
申请人： H. Sam Bergh , Jason Wells , Victor Wong , John Gallipeo , Lynn Van Erden , Anthony F. Volpe , Jeffrey Maag
发明人： H. Sam Bergh , Jason Wells , Victor Wong , John Gallipeo , Lynn Van Erden , Anthony F. Volpe , Jeffrey Maag
CPC分类号： G01N31/10 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00389 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00601 , B01J2219/00689 , B01J2219/00704 , B01J2219/00736 , B01J2219/00747 , C40B60/12
摘要： The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants.
摘要翻译： 本发明公开了一种用于快速分析组合图书馆成员的装置和方法。 该装置包括用于容纳单个文件库构件的多个反应堆容器，在每个容器之间大致相等地分配测试流体的流体处理系统和用于封闭反应堆容器的壳体，壳体限定压力室，其中壳体 被配置为维持基本上高于大气压的压力。 这允许通过在反应器组件上提供小的压差同时筛选高压力下的文库构件。 基于它们催化流体反应物转化的能力，所公开的装置对于筛选文库成员特别有用。
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3.发明授权Apparatus for pressing and other mechanical treatment of materials such as catalysts 失效用于诸如催化剂的材料的压制和其它机械处理的装置公开(公告)号：US07111802B2
公开(公告)日：2006-09-26
申请号：US10880412
申请日：2004-06-28
申请人： Claus G. Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
发明人： Claus G. Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
IPC分类号： B02C19/12
CPC分类号： B07B1/00 , B01J19/0046 , B01J35/10 , B01J37/0036 , B01J37/009 , B01J2219/00313 , B01J2219/00319 , B01J2219/00351 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/007 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5025 , B22F2998/00 , C40B30/08 , C40B40/18 , G01N31/10 , B22F9/04
摘要： Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.
摘要翻译： 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，涉及用于同时进行诸如研磨，混合，压制，粉碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。
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4.发明授权公开(公告)号：US06755364B2
公开(公告)日：2004-06-29
申请号：US09902552
申请日：2001-07-09
申请人： Claus Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
发明人： Claus Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
IPC分类号： B02C1912
CPC分类号： B07B1/00 , B01J19/0046 , B01J35/10 , B01J37/0036 , B01J37/009 , B01J2219/00313 , B01J2219/00319 , B01J2219/00351 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/007 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5025 , B22F2998/00 , C40B30/08 , C40B40/18 , G01N31/10 , B22F9/04
摘要： Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.
摘要翻译： 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，涉及用于同时进行诸如研磨，混合，压制，粉碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。
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公开(公告)号：US07503515B2
公开(公告)日：2009-03-17
申请号：US11519358
申请日：2006-09-11
申请人： Claus G. Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
发明人： Claus G. Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
IPC分类号： B02C17/18
CPC分类号： B07B1/00 , B01J19/0046 , B01J35/10 , B01J37/0036 , B01J37/009 , B01J2219/00313 , B01J2219/00319 , B01J2219/00351 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/007 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5025 , B22F2998/00 , C40B30/08 , C40B40/18 , G01N31/10 , B22F9/04
摘要： Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.
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公开(公告)号：US06971593B2
公开(公告)日：2005-12-06
申请号：US10641906
申请日：2003-08-15
申请人： Claus Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
发明人： Claus Lugmair , Alfred Hagemeyer , Lynn Van Erden , Anthony F. Volpe, Jr. , David M. Lowe , Yumin Liu
CPC分类号： B07B1/00 , B01J19/0046 , B01J35/10 , B01J37/0036 , B01J37/009 , B01J2219/00313 , B01J2219/00319 , B01J2219/00351 , B01J2219/00481 , B01J2219/00484 , B01J2219/00495 , B01J2219/00585 , B01J2219/007 , B01J2219/00704 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5025 , B22F2998/00 , C40B30/08 , C40B40/18 , G01N31/10 , B22F9/04
摘要： Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.
摘要翻译： 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，涉及用于同时进行诸如研磨，混合，压制，粉碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。
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7.发明授权公开(公告)号：US07858049B2
公开(公告)日：2010-12-28
申请号：US11961326
申请日：2007-12-20
申请人： Matthew F. Smith , John F. Varni , G. Cameron Dales , Trevor G. Frank , Rakesh Jain , Lynn Van Erden
发明人： Matthew F. Smith , John F. Varni , G. Cameron Dales , Trevor G. Frank , Rakesh Jain , Lynn Van Erden
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00313 , B01J2219/00335 , B01J2219/00337 , B01J2219/00373 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , C40B40/14 , C40B60/14 , Y10T436/2575 , Y10T436/25875
摘要： A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.
摘要翻译： 一种并联反应器系统，包括用于保持反应混合物的反应器中的反应器和容器，以及用于将流体反应材料引入容器的插管。 机器人系统可操作以将插管插入反应器中的插管通道中，用于将反应材料（包括冷凝气体）输送到相应的容器，并且在输送后从插管通道中抽出插管。 还公开了相关方法。
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8.发明申请公开(公告)号：US20080138260A1
公开(公告)日：2008-06-12
申请号：US11961326
申请日：2007-12-20
申请人： Matthew F. Smith , John F. Varni , G. Cameron Dales , Trevor G. Frank , Rakesh Jain , Lynn Van Erden
发明人： Matthew F. Smith , John F. Varni , G. Cameron Dales , Trevor G. Frank , Rakesh Jain , Lynn Van Erden
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00313 , B01J2219/00335 , B01J2219/00337 , B01J2219/00373 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , C40B40/14 , C40B60/14 , Y10T436/2575 , Y10T436/25875
摘要： A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.
摘要翻译： 一种并联反应器系统，包括用于保持反应混合物的反应器中的反应器和容器，以及用于将流体反应材料引入容器的插管。 机器人系统可操作以将插管插入反应器中的插管通道中，用于将反应材料（包括冷凝气体）输送到相应的容器，并且在输送后从插管通道中抽出插管。 还公开了相关方法。
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公开(公告)号：US06994827B2
公开(公告)日：2006-02-07
申请号：US09873176
申请日：2001-06-01
申请人： Adam Safir , Ralph Nielsen , Thomas H. McWaid , Richard Tiede , Lynn Van Erden
发明人： Adam Safir , Ralph Nielsen , Thomas H. McWaid , Richard Tiede , Lynn Van Erden
CPC分类号： B01F7/167 , B01F7/00258 , B01F7/00266 , B01F7/00291 , B01F7/00416 , B01F7/00575 , B01F15/00207 , B01F2215/0037 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00335 , B01J2219/00337 , B01J2219/00342 , B01J2219/00353 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , C40B40/14 , C40B60/14 , G01N35/1079
摘要： Parallel semi-continuous or continuous reactors are disclosed. The parallel reactors preferably comprise four or more reaction vessels. The reaction vessels are preferably small volume reaction vessels, preferably pressure reaction vessels, and/or preferably integral with a common reactor block. The reaction vessels can comprise shaft-driven stirrers. At least two, preferably at least three or at least four liquid feed lines can provide selective fluid communication between each of the reaction vessels and one or more liquid reagent sources. Additional features, suitable in connection with parallel reactors or with single reaction vessels are also disclosed.
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公开(公告)号：US07754165B2
公开(公告)日：2010-07-13
申请号：US11708301
申请日：2007-02-20
申请人： Lynn Van Erden , Howard Turner , David M. Lowe
发明人： Lynn Van Erden , Howard Turner , David M. Lowe
CPC分类号： B01L3/5025 , B01J3/04 , B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00315 , B01J2219/00335 , B01J2219/00337 , B01J2219/00418 , B01J2219/00423 , B01J2219/00477 , B01J2219/00585 , B01J2219/00601 , B01J2219/00704 , B01J2219/0072 , B01J2219/00736 , G01N35/028
摘要： An apparatus for use in parallel reaction of materials. The apparatus includes a base having a plurality of reaction wells, each of the reaction wells having a closed lower end and open upper end for receiving reactant materials. A cover is configured for sealing engagement with the base to form a housing enclosing the plurality of reaction wells and defining a common pressure chamber in communication with the reaction wells. The apparatus further includes an inlet port in communication with the pressure chamber for supplying pressurized fluid to the chamber to pressurize the reaction wells. The housing is configured to sustain a pressure substantially above atmospheric pressure.
摘要翻译： 用于材料平行反应的装置。 该设备包括具有多个反应孔的基底，每个反应孔具有封闭的下端和敞开的上端，用于接收反应物料。 盖被配置为与基座密封接合以形成封闭多个反应井的壳体，并且限定与反应井连通的公共压力室。 该设备还包括与压力室连通的入口端口，用于将加压流体供应到室以对反应井加压。 壳体构造成承受基本上高于大气压的压力。
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