利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

151 条记录 (耗时 0.072 秒)

    Human chemotactic protein
    1.
    发明申请
    Human chemotactic protein 审中-公开
    人趋化蛋白

    公开(公告)号：US20050118680A1

    公开(公告)日：2005-06-02

    申请号：US11035998

    申请日：2005-01-18

    申请人： Haodong Li ,  Steven Ruben ,  Granger Sutton

    发明人： Haodong Li ,  Steven Ruben ,  Granger Sutton

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/12 ,  C12N15/19 ,  A61K38/19 ,  C07H21/04 ,  C07K14/705

    CPC分类号： C07K14/523 ,  A61K38/00

    摘要： A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

    摘要翻译： 公开了人趋化多肽，编码它的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了将多肽用于多种目的的方法，包括：干细胞动员，髓过保护，神经元保护，治疗肿瘤，伤口愈合，治疗寄生虫感染和调节造血。 还公开了多肽拮抗剂和用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病的本发明多肽的改变水平的诊断测定。

    Polynucleotide encoding macrophage inflammatory protein .gamma.
    4.
    发明授权
    Polynucleotide encoding macrophage inflammatory protein .gamma. 失效
    多核苷酸编码巨噬细胞炎症蛋白γ

    公开(公告)号：US5556767A

    公开(公告)日：1996-09-17

    申请号：US173209

    申请日：1993-12-22

    申请人： Craig A. Rosen ,  Haodong Li ,  Steven Ruben ,  Mark D. Adams

    发明人： Craig A. Rosen ,  Haodong Li ,  Steven Ruben ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N15/12

    CPC分类号： C07K14/523 ,  C07K16/24 ,  A61K38/00

    摘要： There is disclosed a human macrophage inflammatory protein-1 .gamma. (MIP-1 .gamma.) polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of various associated diseases.

    摘要翻译： 公开了人巨噬细胞炎症蛋白-1（MIP-1γ）多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽并产生针对这种多肽的抗体的方法。 本发明的另一方面提供本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。

    Macrophage inflammatory protein-3 and -4
    9.
    发明授权
    Macrophage inflammatory protein-3 and -4 失效
    巨噬细胞炎症蛋白-3和-4

    公开(公告)号：US5504003A

    公开(公告)日：1996-04-02

    申请号：US208339

    申请日：1994-03-08

    申请人： Haodong Li ,  Steven Ruben

    发明人： Haodong Li ,  Steven Ruben

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N5/10 ,  C12N15/12 ,  C12P21/06

    CPC分类号： C07K14/523 ,  C07K16/24 ,  A61K38/00

    摘要： There is disclosed a human macrophage inflammatory protein-3 (MIP-3) and a human macrophage inflammatory protein-4 (MIP-4) polypeptides and DNA (RNA) encoding such polypeptides. There is also provided a procedure for producing such polypeptides by recombinant techniques and for producing antibodies against such polypeptides. In the invention there is also provided antagonist/inhibitors against such polypeptides which inhibit the functioning of such polypeptides. Another aspect of the invention provides a combination of the polypeptides of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptides for the treatment of various associated diseases.

    摘要翻译： 公开了人巨噬细胞炎症蛋白-3（MIP-3）和人巨噬细胞炎症蛋白-4（MIP-4）多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽并产生针对这种多肽的抗体的方法。 在本发明中，还提供了抑制这种多肽功能的这种多肽的拮抗剂/抑制剂。 本发明的另一方面提供了本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。

    Follistatin-3
    10.
    发明申请
    Follistatin-3 有权

    公开(公告)号：US20070275895A1

    公开(公告)日：2007-11-29

    申请号：US11738846

    申请日：2007-04-23

    申请人： D. Duan ,  Steven Ruben

    发明人： D. Duan ,  Steven Ruben

    IPC分类号： C07K14/435 ,  A61K38/17 ,  A61P15/00 ,  A61P19/00 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10 ,  C07K16/18 ,  A61P35/00 ,  C07H21/04

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/021 ,  C12N2799/026

    摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

    摘要翻译： 本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。 特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。 还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。