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公开(公告)号：US09340577B2
公开(公告)日：2016-05-17
申请号：US10817970
申请日：2004-04-06
申请人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
发明人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
IPC分类号： A61K38/10 , A61K39/145 , C07K7/08 , C07K7/06 , A61K39/02 , A61K39/12 , C07K14/74 , A61K38/00 , A61K39/00
CPC分类号： A61K38/00 , A61K38/10 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/145 , A61K2039/5158 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K2319/01 , C07K2319/33 , C07K2319/40 , C12N2710/00088 , C12N2710/20034 , C12N2730/10134 , C12N2740/16034 , C12N2770/24234
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. One such peptide, NMLSTVLGV (SEQ ID NO: 183) is useful to elicit an immune response against influenza. The present invention also provides a heteropolymer of an isolated immunogenic peptide less than 15 amino acids in length comprising the oligopeptide NMLSTVLGV (SEQ ID NO: 183) and at least one different peptide.
摘要翻译： 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 一种这样的肽NMLSTVLGV（SEQ ID NO：183）可用于引发针对流感的免疫应答。 本发明还提供了长度小于15个氨基酸的分离的免疫原性肽的杂聚物，其包含寡肽NMLSTVLGV（SEQ ID NO：183）和至少一种不同的肽。
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公开(公告)号：US20080260762A1
公开(公告)日：2008-10-23
申请号：US11978519
申请日：2007-10-30
申请人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
发明人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.
摘要翻译： 本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。 所述肽可用于引发针对所需抗原的免疫应答。
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3.发明申请Inducing cellar immune responses to hepatitis C virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导丙型肝炎病毒的地窖免疫应答公开(公告)号：US20090304746A1
公开(公告)日：2009-12-10
申请号：US11980348
申请日：2007-10-31
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chesnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chesnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
IPC分类号： A61K39/29 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61K31/7052 , C07K14/00 , G01N33/53 , A61K38/16 , A61P31/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K2319/00 , C12N2770/24222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare HCV epitopes, and to develop epitope-based vaccines directed towards HCV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HCV infection.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备HCV表位的机制的知识，并开发针对HCV的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗HCV感染。
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4.发明授权Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导恶性疟原虫的细胞免疫应答公开(公告)号：US09266930B1
公开(公告)日：2016-02-23
申请号：US09390061
申请日：1999-09-03
申请人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chestnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Brian D. Livingston , Robert Chestnut , Denise Marie Baker , Esteban Celis , Ralph T. Kubo , Howard M. Grey
IPC分类号： A61K39/002 , A61K39/015 , C07K14/44 , C07K14/445 , A61K39/00
CPC分类号： A61K39/015 , A61K39/0011 , A61K39/002 , A61K2039/5154 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/605 , C07K7/08 , C07K14/005 , C07K14/445 , C07K14/70539 , C07K2319/00 , C07K2319/01 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , Y02A50/412
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare Plasmodium falciparum epitopes, and to develop epitope-based vaccines directed towards malaria. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of malaria. In particular, this application discloses isolated peptides comprising oligopeptides, for example the oligopeptide GVSENIFLK, or isolated peptides conjugated with T helper peptides that are used as antigens in epitope-based vaccines to prevent and/or treat malaria.
摘要翻译： 本发明使用我们对抗原被T细胞识别和制备恶性疟原虫表位的机制的知识，并开发针对疟疾的基于表位的疫苗。 更具体地说，本申请将我们发现的药物组合物和使用方法用于预防和治疗疟疾。 特别地，本申请公开了分离的肽，其包含寡肽，例如寡肽GVSENIFLK，或与T辅助肽缀合的分离肽，其用作基于表位的疫苗中的抗原以预防和/或治疗疟疾。
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5.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20090311283A1
公开(公告)日：2009-12-17
申请号：US11976998
申请日：2007-10-30
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号： C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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6.发明授权Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 失效使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US06689363B1
公开(公告)日：2004-02-10
申请号：US09239043
申请日：1999-01-27
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
IPC分类号： A61K3800
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K2039/70 , C07K14/005 , C07K14/33 , C07K14/4746 , C07K14/705 , C07K14/70539 , C07K14/82 , C12N2730/10122 , C12N2740/16022 , C12N2760/16122 , C12N2770/24222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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7.发明申请Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions 审中-公开使用肽和核酸组合物诱导对乙型肝炎病毒的细胞免疫应答公开(公告)号：US20110097352A9
公开(公告)日：2011-04-28
申请号：US11976998
申请日：2007-10-30
申请人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
发明人： Alessandro Sette , John Sidney , Scott Southwood , Maria A. Vitiello , Brian D. Livingston , Esteban Celis , Ralph T. Kubo , Howard M. Grey , Robert W. Chesnut
CPC分类号： C07K14/005 , A61K31/7088 , A61K2039/53 , A61K2039/55516 , A61K2039/6031 , A61K2039/70 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原的机制的知识来开发针对HBV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HBV感染中的药物组合物和使用方法的发现。
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8.发明申请公开(公告)号：US20090214632A1
公开(公告)日：2009-08-27
申请号：US12292281
申请日：2008-11-14
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： A61K39/12 , C07K14/005 , A61K9/127 , C12N5/08 , C07H21/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
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9.发明授权Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导对人乳头瘤病毒的细胞免疫应答公开(公告)号：US07026443B1
公开(公告)日：2006-04-11
申请号：US09641528
申请日：2000-08-15
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： C07K7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原识别和制备人乳头状瘤病毒（HPV）表位的机制的知识，并开发针对HPV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HPV感染中的药物组合物和使用方法的发现。
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10.发明授权Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions 有权使用肽和核酸组合物诱导对人乳头瘤病毒的细胞免疫应答公开(公告)号：US07572882B2
公开(公告)日：2009-08-11
申请号：US10149136
申请日：2000-12-11
申请人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
发明人： Alessandro Sette , John Sidney , Scott Southwood , Robert Chesnut , Esteban Celis , Howard M. Grey
IPC分类号： A61K38/03
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/57 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
摘要翻译： 本发明使用我们对T细胞识别抗原识别和制备人乳头状瘤病毒（HPV）表位的机制的知识，并开发针对HPV的基于表位的疫苗。 更具体地说，本申请介绍了我们在预防和治疗HPV感染中的药物组合物和使用方法的发现。
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