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公开(公告)号：US11338291B2
公开(公告)日：2022-05-24
申请号：US16473821
申请日：2017-12-26
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
Inventor： Koen Johannes Hubertus Gerardus de Wijs , Chengxun Liu
Abstract: Disclosed herein are microfluidic actuators for selecting objects in a fluid stream comprising a plurality of objects. In some embodiments, the actuator comprises an object detection means adapted for, upon arrival of an object, identifying whether an object is an object of interest. It further comprises a heater adapted for generating a jet flow for deflecting an object of interest from the fluid stream and a controller for activating the heater as function of the detection of an object of interest using a nucleation signal. The controller is adapted for obtaining temperature information of the heater and for adjusting a nucleation signal for the heater taking into account the obtained temperature information. Also disclosed are microfluidic systems and diagnostic devices comprising the microfluidic actuators of the disclosure, as well as methods of use thereof.
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公开(公告)号：US20170341078A1
公开(公告)日：2017-11-30
申请号：US15526922
申请日：2015-11-19
Applicant: IMEC VZW
Inventor： Chengxun Liu , Peter Peumans , Liesbet Lagae , Bivragh Majeed
CPC classification number: B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0864 , B01L2300/1827 , B01L2400/0442 , B01L2400/046 , B01L2400/06 , G01N2015/1006 , G01N2015/149
Abstract: The present disclosure relates to microbubble generator devices for deflecting objects in a liquid, systems for sorting objects that utilize such devices, and methods for fabricating such devices. At least one embodiment relates to a micro-fluidic device for deflecting objects in a liquid. The device includes a substrate for providing an object-containing liquid thereon. The device also includes a microbubble generator that includes at least one microbubble generating element. The microbubble generator is located on a surface of the substrate and in direct contact with the object-containing liquid when the object-containing liquid is provided on the substrate. The at least one microbubble generating element is configured to deflect a single object in the object-containing liquid through generation of a plurality of microbubbles.
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公开(公告)号：US11971385B2
公开(公告)日：2024-04-30
申请号：US17018368
申请日：2020-09-11
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R & D
Inventor： Koen Martens , Chengxun Liu , Camila Dalben Madeira Campos , Rita Vos
IPC: G01N27/447
CPC classification number: G01N27/44752 , G01N27/44791
Abstract: A cyclic capillary electrophoresis device includes a capillary channel that forms a closed loop. The capillary channel comprises an inner half facing toward a space enclosed by the loop, where the inner half having an inner wall of first charge density, and an outer half facing away from the space enclosed by the loop, where the outer half having an inner wall surface of second charge density. A difference between the first and the second charge densities exists or can be turned on. The difference is configured to create a smaller average electroosmotic flow velocity in the inner half than in the outer half.
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公开(公告)号：US11511275B2
公开(公告)日：2022-11-29
申请号：US16959311
申请日：2018-12-20
Applicant: IMEC VZW
Inventor： Chengxun Liu
Abstract: A method for detecting, sorting, purifying and characterizing objects of interest in a liquid sample. The method comprises preparing, in a preparation module ON) of a microfluidic router system, the liquid sample for processing. Preparing comprises transporting the sample through a microfluidic channel, and forwarding the prepared sample from an outlet of the preparation module into an inlet of a routing module. Forwarding comprises coupling a microfluidic flow between the outlet and the inlet to passively buffer against or actively compensate for variations in a flow rate of the prepared sample at the outlet, and diverting the objects of interest from the microfluidic flow. Forwarding the sample comprises sensing a flow characteristic of the sample in preparation, routing module, or in flow connection, and controlling a flow control element taking the sensed characteristic into account to compensate for a variation in the flow rate by a closed-loop flow control.
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公开(公告)号：US20210199623A1
公开(公告)日：2021-07-01
申请号：US17129211
申请日：2020-12-21
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R & D
Inventor： Chengxun Liu , Andim Stassen , Ying Ting Set
Abstract: A method for continuously separating components from a sample includes providing a field-flow fractionation device including: a channel coupled to a flow generator for translocating the sample components along the channel in a first direction, an actuator for translocating the sample components in a second direction, at an angle with the first direction, and an array of electrodes electrically or capacitively connected to an AC power source, operating the actuator so as to translocate the sample components in a second direction at an angle with the first direction, operating the AC power source so as to generate an AC electric field between adjacent rows, and operating the flow generator, collecting sample components from the sample outlets.
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Patent Agency Ranking
公开(公告)号：US20210199211A1
公开(公告)日：2021-07-01
申请号：US17135192
申请日：2020-12-28
Applicant: IMEC VZW
Inventor： Lei Zhang , Tim Stakenborg , Chengxun Liu , David Cheyns
IPC: F16K31/128 , F16K7/12 , F16K11/24 , F16K31/00 , F16K7/10
Abstract: Example embodiments relate to microfluidic devices for controlling pneumatic microvalves. One embodiment includes a microfluidic device for independently controlling a plurality of pneumatic microvalves. The microfluidic device is couplable to a pressure source. The microfluidic device includes a first substrate. The microfluidic device also includes a flexible membrane covering the first substrate. Additionally, the microfluidic device includes a second substrate covering the flexible membrane. Further, the microfluidic device includes one or more fluidic channels at least partially defined in the first substrate. In addition, the microfluidic device includes a pressure couplable to the pressure source and branching into a plurality of pressure channels. Still further, the microfluidic device includes at least one pressure control switch per pressure channel.
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公开(公告)号：US20210080427A1
公开(公告)日：2021-03-18
申请号：US17018368
申请日：2020-09-11
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R & D
Inventor： Koen Martens , Chengxun Liu , Camila Dalben Madeira Campos , Rita Vos
IPC: G01N27/447
Abstract: A cyclic capillary electrophoresis device includes a capillary channel that forms a closed loop. The capillary channel comprises an inner half facing toward a space enclosed by the loop, where the inner half having an inner wall of first charge density, and an outer half facing away from the space enclosed by the loop, where the outer half having an inner wall surface of second charge density. A difference between the first and the second charge densities exists or can be turned on. The difference is configured to create a smaller average electroosmotic flow velocity in the inner half than in the outer half.
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公开(公告)号：US10124338B2
公开(公告)日：2018-11-13
申请号：US15526922
申请日：2015-11-19
Applicant: IMEC VZW
Inventor： Chengxun Liu , Peter Peumans , Liesbet Lagae , Bivragh Majeed
Abstract: The present disclosure relates to microbubble generator devices for deflecting objects in a liquid, systems for sorting objects that utilize such devices, and methods for fabricating such devices. At least one embodiment relates to a micro-fluidic device for deflecting objects in a liquid. The device includes a substrate for providing an object-containing liquid thereon. The device also includes a microbubble generator that includes at least one microbubble generating element. The microbubble generator is located on a surface of the substrate and in direct contact with the object-containing liquid when the object-containing liquid is provided on the substrate. The at least one microbubble generating element is configured to deflect a single object in the object-containing liquid through generation of a plurality of microbubbles.
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公开(公告)号：US20210162414A1
公开(公告)日：2021-06-03
申请号：US16771025
申请日：2018-12-20
Applicant: IMEC VZW
Inventor： Chengxun Liu , Bivragh Majeed , Abdulkadir Yurt
Abstract: A microfluidic routing device for routing objects of interest in a microfluidic flow includes a substrate; a first layer provided on the substrate, in which the first layer forms a bottom wall of a microfluidic channel. At least two holes through the first layer form respectively an inlet and an outlet for the microfluidic channel The microfluidic routing device further includes a second layer spaced away from the first layer, in which the second layer forms a top wall of the microfluidic channel. The second layer is configured to transmit an optical signal from the microfluidic channel. The microfluidic routing device includes an actuator for actuating the objects of interest in a sorting junction of the microfluidic channel.
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公开(公告)号：US10330580B2
公开(公告)日：2019-06-25
申请号：US15179484
申请日：2016-06-10
Applicant: IMEC VZW
Inventor： Richard Min , Liesbet Lagae , Chengxun Liu , Chengjun Huang
Abstract: A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.
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