公开(公告)号：US20070287192A1

公开(公告)日：2007-12-13

申请号：US10598071

申请日：2005-03-02

申请人： James Usowicz ,  Peyton Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

发明人： James Usowicz ,  Peyton Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

IPC分类号： G01N30/02 ,  B01J19/00 ,  G01N30/62 ,  G01N1/28

CPC分类号： G01N21/53 ,  G01N30/32 ,  G01N2030/207

摘要： A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a control means (10) that receives the responses and generates command signals in based on the received response. In a liquid chromatography system, the device is used to determine the volume of components of the fluid system. In addition, the device allow leaks to be detected and permits the fluid in the system to be transported at a optimum speed. The device is well implemented utilizing to a light emitter and light receptor that are sensitive to the fluid in either a gaseous or liquid state.

摘要翻译： 一种用于检测流体系统（14）中的状况并基于该条件启动响应的装置（100）。 该装置包括响应系统中的流体（13）的第一和第二状态的传感器（12）和接收响应的控制装置（10），并基于所接收的响应产生命令信号。 在液相色谱系统中，该装置用于确定流体系统的部件的体积。 此外，该装置允许检测泄漏，并允许系统中的流体以最佳速度被输送。 该装置利用对气体或液态的流体敏感的光发射器和光接收器良好地实现。

公开(公告)号：US07596988B2

公开(公告)日：2009-10-06

申请号：US10598071

申请日：2005-03-02

申请人： James E. Usowicz ,  Peyton C. Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

发明人： James E. Usowicz ,  Peyton C. Beals ,  Russell Keene ,  Richard Kent ,  Miguel Soares ,  John Heden

IPC分类号： G01N30/28 ,  G01N30/32

CPC分类号： G01N21/53 ,  G01N30/32 ,  G01N2030/207

摘要： A device (100) for detecting a condition in a fluid system (14) and initiating a response based on the condition. The device consists of a sensor (12) that responds to a first and second condition of the fluid (13) in the system and a control means (10) that receives the responses and generates command signals in based on the received response. In a liquid chromatography system, the device is used to determine the volume of components of the fluid system. In addition, the device allow leaks to be detected and permits the fluid in the system to be transported at a optimum speed. The device is well implemented utilizing to a light emitter and light receptor that are sensitive to the fluid in either a gaseous or liquid state.

摘要翻译： 一种用于检测流体系统（14）中的状况并基于该条件启动响应的装置（100）。 该装置包括响应系统中的流体（13）的第一和第二状态的传感器（12）和接收响应的控制装置（10），并基于所接收的响应产生命令信号。 在液相色谱系统中，该装置用于确定流体系统的部件的体积。 此外，该装置允许检测泄漏，并允许系统中的流体以最佳速度被输送。 该装置利用对气体或液态的流体敏感的光发射器和光接收器良好地实现。

公开(公告)号：US07917250B2

公开(公告)日：2011-03-29

申请号：US11658985

申请日：2005-08-19

申请人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D11/16 ,  G05B21/00 ,  G01F1/00 ,  G01F7/00 ,  G01F25/00 ,  F01N3/20 ,  G05B1/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream to enhance chromatographic performance related to retention time and reproducibility. The injection event is coordinated with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. Consistent timing with the injection event of the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery generates reproducible results.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流相关的压力扰动以提高与保留时间和再现性相关的色谱性能的系统，装置和方法。 喷射事件与二元溶剂输送系统的主动压力控制协调，以实际消除低压回路在线时的常规压降。 与输送泵活塞的机械位置的注射事件以及起始和随后的梯度递送的一致的时间产生可重现的结果。

公开(公告)号：US08160751B2

公开(公告)日：2012-04-17

申请号：US13035388

申请日：2011-02-25

申请人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, Jr. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D11/16 ,  G05B21/00 ,  G01F1/00 ,  G01F7/00 ,  G01F25/00 ,  F01N3/20 ,  G05B1/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流中相关联的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US20090062966A1

公开(公告)日：2009-03-05

申请号：US11658985

申请日：2005-08-19

申请人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D11/02 ,  G05D7/00

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream (52), to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system (30) to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流（52）相关的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统（30）的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US09523662B2

公开(公告)日：2016-12-20

申请号：US13511691

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： B01D15/16 ,  G01N30/32 ,  G01N30/34 ,  G01N30/88 ,  G01N30/20 ,  G01N30/24 ,  G01N30/86 ,  G01N30/36

CPC分类号： G01N30/20 ,  B01D15/163 ,  B01D15/166 ,  G01N30/24 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  G01N30/8696 ,  G01N2030/322 ,  G01N2030/326 ,  G01N2030/8804

摘要： A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.

摘要翻译： 液相色谱系统包括具有喷射阀的自动进样器，通过该进样阀将样品环内的低压样品引入高压溶剂混合物流中。 溶剂输送系统包括与自动进样器的注射器阀流体连通以将溶剂混合物流输送到其中的泵。 溶剂输送系统还包括处理器，其计算将溶剂混合物流输送到自动进样器的注射器阀所需的泵的数量。 处理器在输送溶剂混合物流期间计算泵的冲程。 响应于等于所计算的冲程次数的冲程计数，处理器发信号通知自动进样器以在泵传送期间将样品引入溶剂混合物流中，在泵输送期间泵执行压力控制以补偿下降 压力。

公开(公告)号：US09519291B2

公开(公告)日：2016-12-13

申请号：US13511667

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： G01N30/24 ,  G05D7/06

CPC分类号： G05D7/0676 ,  G01N30/24

摘要： A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

摘要翻译： 液相色谱系统包括制备用于引入溶剂流的样品的自动进样器和将溶剂流输送到自动进样器的溶剂递送系统。 溶剂流的传送与自动进样器的预注射操作并行发生。 自动进样器开始预注射操作，使样品准备好注入混合物流，溶剂输送系统开始将溶剂流输送到自动进样器。 溶剂流输送的开始与预喷射操作的开始协调，使得溶剂流到达自动进样器时与自动进样器完成预喷射操作大致一致，使得样品准备好进行注射。

公开(公告)号：US20120304745A1

公开(公告)日：2012-12-06

申请号：US13511667

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： G01N1/28 ,  G01N30/84

CPC分类号： G05D7/0676 ,  G01N30/24

摘要： A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

摘要翻译： 液相色谱系统包括制备用于引入溶剂流的样品的自动进样器和将溶剂流输送到自动进样器的溶剂递送系统。 溶剂流的传送与自动进样器的预注射操作并行发生。 自动进样器开始预注射操作，使样品准备好注入混合物流，溶剂输送系统开始将溶剂流输送到自动进样器。 溶剂流输送的开始与预喷射操作的开始协调，使得溶剂流到达自动进样器时与自动进样器完成预喷射操作大致一致，使得样品准备好进行注射。

公开(公告)号：US20110202188A1

公开(公告)日：2011-08-18

申请号：US13035388

申请日：2011-02-25

申请人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

发明人： Stanley P. Pensak, JR. ,  John Heden ,  Steven J. Ciavarini ,  John Lamoureux ,  Miguel Soares

IPC分类号： G05D16/00 ,  G05D11/02

CPC分类号： G01N30/34 ,  G01N35/1097

摘要： Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.

摘要翻译： 用于减轻与将低压分析物样品注入高压HPLC流体流中相关联的压力扰动的系统，装置和方法，以增强与保留时间和再现性相关的色谱性能。 优选实施例通过二元溶剂输送系统的主动压力控制来协调注入运行，以在低压回路在线时基本上消除常规的压降。 通过强制喷射运行，输送泵活塞的机械位置以及开始和随后的梯度输送之间的一致的时间关系来实现增强再现性的另外的益处。

公开(公告)号：US20120303167A1

公开(公告)日：2012-11-29

申请号：US13511691

申请日：2010-11-11

申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

IPC分类号： G05D7/00 ,  B01D15/08

CPC分类号： G01N30/20 ,  B01D15/163 ,  B01D15/166 ,  G01N30/24 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  G01N30/8696 ,  G01N2030/322 ,  G01N2030/326 ,  G01N2030/8804

摘要： A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.

摘要翻译： 液相色谱系统包括具有喷射阀的自动进样器，通过该进样阀将样品环内的低压样品引入高压溶剂混合物流中。 溶剂输送系统包括与自动进样器的注射器阀流体连通以将溶剂混合物流输送到其中的泵。 溶剂输送系统还包括处理器，其计算将溶剂混合物流输送到自动进样器的注射器阀所需的泵的数量。 处理器在输送溶剂混合物流期间计算泵的冲程。 响应于等于所计算的冲程次数的冲程计数，处理器发信号通知自动进样器以在泵传送期间将样品引入溶剂混合物流中，在泵输送期间泵执行压力控制以补偿下降 压力。