公开(公告)号：US11021586B2

公开(公告)日：2021-06-01

申请号：US15438215

申请日：2017-02-21

Applicant: Korea Institute of Science and Technology

Inventor： Nakwon Choi ,  Sohyun Kim ,  Sohyeon Jeong ,  Eui Sung Yoon ,  Changjoon Justin Lee ,  Il-Joo Cho

IPC: B29C43/18 ,  C08J7/043 ,  C08J7/04 ,  C12M3/00 ,  C12M1/12 ,  C12N5/00 ,  C12N5/09

Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.

公开(公告)号：US11685044B2

公开(公告)日：2023-06-27

申请号：US17474384

申请日：2021-09-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sohyun Kim ,  Youngsu Cha

IPC: B25J9/14 ,  F15B21/06 ,  F15B15/10 ,  B25J15/00

CPC classification number: B25J9/142 ,  B25J15/0023 ,  F15B15/10 ,  F15B21/065

Abstract: The present disclosure provides an actuator including a pouch which is sealed and formed with an asymmetric structure, a dielectric fluid which is filled in the pouch, and an electrode which is attached to one surface of the pouch and the other surface opposite the one surface, wherein the pouch includes a first part provided on one side and having a predetermined area, and a second part provided on the other side opposite the one side and having a smaller area than the first part, and when power is applied to the electrodes, the first part or the second part of the pouch is expandable by movement of the dielectric fluid due to the asymmetric structure, and an active plate having the same.

公开(公告)号：US09803167B2

公开(公告)日：2017-10-31

申请号：US14950710

申请日：2015-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Nakwon Choi ,  Eun-Mi Hur ,  Sohyun Kim ,  Sun-Kyoung Im ,  Eui Sung Yoon ,  Changjoon Justin Lee

IPC: B29C55/00 ,  C12M1/42 ,  B29C55/02 ,  B29C55/20 ,  B29C55/12 ,  C08J5/00 ,  A61L27/16 ,  A61L27/38 ,  A61L27/50

CPC classification number: C12M35/04 ,  A61L27/165 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L2430/32 ,  B29C55/02 ,  B29C55/023 ,  B29C55/12 ,  B29C55/20 ,  C08J5/00

Abstract: The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.