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公开(公告)号：US09925536B2
公开(公告)日：2018-03-27
申请号：US12670088
申请日：2008-07-23
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
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公开(公告)号：US08846313B2
公开(公告)日：2014-09-30
申请号：US12513597
申请日：2007-11-06
IPC分类号： C12Q1/68 , C12M1/34 , C12P19/34 , G01N21/00 , G01N21/75 , C07H21/04 , B01L3/00 , B01J19/00 , B01L9/00 , B01L7/00
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络 至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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公开(公告)号：US20100255473A1
公开(公告)日：2010-10-07
申请号：US12670088
申请日：2008-07-23
IPC分类号： C12Q1/68
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，以及用于确定指示靶分子的存在和/或量的值;互连的微流体网络 至少第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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公开(公告)号：US20110014606A1
公开(公告)日：2011-01-20
申请号：US12513597
申请日：2007-11-06
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络 至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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