公开(公告)号：US5138059A

公开(公告)日：1992-08-11

申请号：US380379

申请日：1989-07-17

申请人： Keiichi Takahashi ,  Michio Ichimura ,  Shigeo Katsumata ,  Tatsuhiro Ogawa ,  Makoto Morimoto ,  Tadashi Ashizawa ,  Masaji Kasai ,  Kenichi Muroi ,  Hiromitsu Saito ,  Hiroshi Sano ,  Toru Yasuzawa

发明人： Keiichi Takahashi ,  Michio Ichimura ,  Shigeo Katsumata ,  Tatsuhiro Ogawa ,  Makoto Morimoto ,  Tadashi Ashizawa ,  Masaji Kasai ,  Kenichi Muroi ,  Hiromitsu Saito ,  Hiroshi Sano ,  Toru Yasuzawa

IPC分类号： C12P17/18 ,  A61K31/40 ,  A61K31/435 ,  A61P31/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C12N1/20 ,  C12R1/465

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.

公开(公告)号：US4847387A

公开(公告)日：1989-07-11

申请号：US199043

申请日：1988-03-17

申请人： Hirofumi Nakano ,  Isami Takahashi ,  Fusao Tomita ,  Kozo Asano ,  Toru Yasuzawa ,  Tadashi Ashizawa ,  Keiichi Takahashi

发明人： Hirofumi Nakano ,  Isami Takahashi ,  Fusao Tomita ,  Kozo Asano ,  Toru Yasuzawa ,  Tadashi Ashizawa ,  Keiichi Takahashi

IPC分类号： C07H7/06 ,  C07H15/12 ,  C07H17/04 ,  C12P19/26 ,  C12P19/44

CPC分类号： C07H15/12 ,  C07H17/04 ,  C12P19/26 ,  C12P19/44

摘要： The present invention relates to novel compounds DC-92B and DC-92D having anthraquinone moiety and represented by the following planar structural formula (I) and to a process for producing the same. These compounds can be produced by culture of a microorganism belonging to the genus Actinomadura, and are useful as medicaments because of their antibacterial and anti-tumor activities. ##STR1## wherein R is a group represented by formula (II) or formula (III): ##STR2##

公开(公告)号：US5344926A

公开(公告)日：1994-09-06

申请号：US79560

申请日：1993-06-22

申请人： Chikara Murakata ,  Toshimitsu Takiguchi ,  Shigeo Katsumata ,  Akira Mihara ,  Keiichi Takahashi ,  Hiromitsu Saito ,  Shiro Akinaga ,  Masami Okabe ,  Yutaka Saito

发明人： Chikara Murakata ,  Toshimitsu Takiguchi ,  Shigeo Katsumata ,  Akira Mihara ,  Keiichi Takahashi ,  Hiromitsu Saito ,  Shiro Akinaga ,  Masami Okabe ,  Yutaka Saito

IPC分类号： C07D498/22 ,  C07H9/06 ,  C07H19/04

CPC分类号： C07D498/22 ,  C07H19/04 ,  C07H9/06

摘要： Disclosed is a process for producing a staurosporine derivative represented by Formula (I): Q is defined as in specification: ##STR1## The staurosporine derivative (I-1) possesses selective protein kinase C-inhibitory and cell growth-inhibiting activities, and platelet-increasing activity.

摘要翻译： （I）星形孢菌素衍生物（I-1）具有选择性蛋白激酶C抑制和细胞生长抑制活性的方法， ，血小板增多活性。

公开(公告)号：US4593097A

公开(公告)日：1986-06-03

申请号：US575294

申请日：1984-01-30

申请人： Fusao Tomita ,  Keiichi Takahashi ,  Isao Kawamoto ,  Kozo Asano ,  Makoto Morimoto ,  Tadashi Ashizawa ,  Kazuhisa Fujimoto

发明人： Fusao Tomita ,  Keiichi Takahashi ,  Isao Kawamoto ,  Kozo Asano ,  Makoto Morimoto ,  Tadashi Ashizawa ,  Kazuhisa Fujimoto

IPC分类号： A61K31/495 ,  A61P1/04 ,  A61P31/04 ,  A61P35/00 ,  C07D241/46 ,  C12P17/12 ,  C12R1/465

CPC分类号： C12P17/12 ,  C07D241/46

摘要： Phenazine compounds represented by the formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted or substituted lower alkanoyl group, or an unsubstituted or substituted arylcarbonyl group have antibacterial and anti-tumor activities.Some of these compounds are produced by incubation of a microorganism.

摘要翻译： 由下式表示的吩嗪化合物：其中R为氢原子，未取代或取代的低级烷酰基或未取代或取代的芳基羰基具有抗菌和抗肿瘤活性。 这些化合物中的一些通过温育微生物产生。

公开(公告)号：US5101038A

公开(公告)日：1992-03-31

申请号：US458543

申请日：1989-12-28

申请人： Hirofumi Nakano ,  Isami Takahashi ,  Isao Kawamoto ,  Toru Yasuzawa ,  Keiichi Takahashi ,  Eiji Kobayashi

发明人： Hirofumi Nakano ,  Isami Takahashi ,  Isao Kawamoto ,  Toru Yasuzawa ,  Keiichi Takahashi ,  Eiji Kobayashi

IPC分类号： A61K31/40 ,  A61P35/00 ,  C07D487/04 ,  C07D487/10 ,  C12N1/20 ,  C12P17/18 ,  C12R1/465

CPC分类号： C07D487/10 ,  C12P17/182

摘要： A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.

公开(公告)号：US4650869A

公开(公告)日：1987-03-17

申请号：US606902

申请日：1984-05-04

申请人： Tadashi Hirata ,  Shigeru Kobayashi ,  Keiichi Takahashi ,  Makoto Morimoto ,  Yuko Arai

发明人： Tadashi Hirata ,  Shigeru Kobayashi ,  Keiichi Takahashi ,  Makoto Morimoto ,  Yuko Arai

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C07D498/08 ,  C07D498/22 ,  C07D487/18

CPC分类号： C07D471/18 ,  C07D498/22

摘要： A compound represented by the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is a hydroxymethyl group and Y is a cyano group, and when R is a lower alkyl group, X and Y may combine to form --CH.sub.2 --O--, and salts thereof, process for preparing the same, and an anti-tumor composition containing the same, which is improved in stability in comparison with a starting compound DC-52.

摘要翻译： 由下式表示的化合物：其中r是氢原子或低级烷基，X是羟甲基，Y是氰基，当R是低级烷基时，X和Y可以组合形成 -CH 2 -O-及其盐，其制备方法和含有该组合物的抗肿瘤组合物，与起始化合物DC-52相比，其稳定性提高。

公开(公告)号：US09876227B2

公开(公告)日：2018-01-23

申请号：US14414809

申请日：2013-10-15

申请人： Yutaka Oyama ,  Keiichi Takahashi

发明人： Yutaka Oyama ,  Keiichi Takahashi

IPC分类号： H01M4/525 ,  B60L3/00 ,  B60L3/04 ,  B60L11/00 ,  B60L11/18 ,  H01M4/131 ,  H01M4/1391 ,  H01M4/505 ,  H01M4/62 ,  H01M10/0567 ,  H01M10/42 ,  H01M2/34 ,  H01M10/058 ,  H01M10/0525 ,  H01M4/02

CPC分类号： H01M4/525 ,  B60L3/0046 ,  B60L3/04 ,  B60L11/005 ,  B60L11/1861 ,  B60L11/1864 ,  B60L11/1874 ,  B60L11/1877 ,  B60L11/1879 ,  B60L2240/545 ,  B60L2240/547 ,  B60L2240/549 ,  H01M2/34 ,  H01M4/131 ,  H01M4/1391 ,  H01M4/505 ,  H01M4/625 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/058 ,  H01M10/4235 ,  H01M2004/021 ,  H01M2200/20 ,  H01M2220/20 ,  Y02T10/7005 ,  Y02T10/7022 ,  Y02T10/7044 ,  Y02T10/7061 ,  Y10T29/49115

摘要： The sealed nonaqueous electrolyte secondary battery includes a nonaqueous electrolyte containing a gas generator that is decomposed to generate a gas when a prescribed battery voltage is exceeded, and a battery case that includes a current interrupt device that operates when the pressure within the battery case rises accompanying the gas generation. A positive electrode (10) has a positive electrode mixture layer (14) that contains at least a positive electrode active material (16). This positive electrode mixture layer (14) contains, as conductive agents, electroconductive carbon particles (18) and an expanded graphite (17) that has an average pore diameter of 0.2 μm to 0.5 μm.

公开(公告)号：US08888870B2

公开(公告)日：2014-11-18

申请号：US13252808

申请日：2011-10-04

申请人： Yasutaka Kogetsu ,  Masaya Ugaji ,  Keiichi Takahashi ,  Shinji Mino ,  Nobuaki Nagao ,  Satoshi Shibutani ,  Kazuyoshi Honda

发明人： Yasutaka Kogetsu ,  Masaya Ugaji ,  Keiichi Takahashi ,  Shinji Mino ,  Nobuaki Nagao ,  Satoshi Shibutani ,  Kazuyoshi Honda

IPC分类号： H01M4/134 ,  H01M4/04 ,  H01M4/1395 ,  H01M4/38 ,  H01M4/02

CPC分类号： H01M4/134 ,  H01M4/0423 ,  H01M4/0426 ,  H01M4/1395 ,  H01M4/38 ,  H01M2004/021 ,  Y02E60/122 ,  Y02P70/54 ,  Y10T29/49115

摘要： In order to enhance charge and discharge efficiency and to improve cycle characteristics by increasing a facing area between a positive electrode active material and a negative electrode active material, in a negative electrode for lithium secondary battery having a current collector and an active material layer carried on the current collector, the active material layer includes a plurality of columnar particles. The columnar particles include an element of silicon, and are tilted toward the normal direction of the current collector. Angle θ formed between the columnar particles and the normal direction of the current collector is preferably 10°≦θ

摘要翻译： 为了提高充放电效率，通过增加正极活性物质和负极活性物质之间的面积来提高循环特性，在具有集电体和活性物质层的锂二次电池用负极中， 集电体，活性物质层包括多个柱状颗粒。 柱状颗粒包括硅元素，并且朝向集电体的法线方向倾斜。 角度与角度 柱状颗粒与集电体的法线方向之间形成的膜优选为10°＆lt; 90°。

公开(公告)号：US08770825B2

公开(公告)日：2014-07-08

申请号：US12733980

申请日：2008-09-10

申请人： Yusuke Takemoto ,  Keiichi Takahashi ,  Takahiro Shibuya

发明人： Yusuke Takemoto ,  Keiichi Takahashi ,  Takahiro Shibuya

IPC分类号： B01F7/04

CPC分类号： B01F7/042 ,  B01F3/1221 ,  B01F7/003 ,  B01F7/00425 ,  B01F7/022

摘要： A kneading apparatus has a pair of rotary shafts mounted to undergo rotation in different directions of rotation and at different rotational speeds from one another. Stirring members are helically arranged on outer peripheries of the rotary shafts at predetermined helical and angular pitches for kneading an object during rotation of the rotary shafts. The helical pitch of the stirring members of one of the rotary shafts has an inverse helix from that of the stirring members of the other rotary shaft. The stirring members have surfaces with a first phase configured to move the kneaded object in a feed direction or a second phase symmetrical to the first phase and configured to move the kneaded object in a direction reverse to the feed direction. The stirring members are arranged so that the first and second phases cyclically repeat in a predetermined sequence in axial directions of the rotary shafts.

摘要翻译： 捏合装置具有一对旋转轴，其安装成在不同的旋转方向和不同的转速下进行旋转。 旋转构件螺旋地布置在旋转轴的外周上，以预定的螺旋和角度间距在旋转轴旋转期间捏合物体。 其中一个旋转轴的搅拌构件的螺旋螺距与另一个旋转轴的搅拌构件的螺旋螺距相反。 搅拌构件具有表面，其具有第一相，其构造成使得捏合物沿进给方向或与第一相对称的第二相移动并且构造成使得捏合物沿与进给方向相反的方向移动。 搅拌构件被布置成使得第一和第二相在旋转轴的轴向方向上以预定顺序循环重复。

公开(公告)号：US08399045B2

公开(公告)日：2013-03-19

申请号：US12673907

申请日：2008-07-22

申请人： Keiichi Takahashi ,  Shinji Mino ,  Tsunenori Yoshida

发明人： Keiichi Takahashi ,  Shinji Mino ,  Tsunenori Yoshida

IPC分类号： B05D1/12

CPC分类号： C23C24/04

摘要： A film formation method according to the present invention includes the step of forming a film of material powders 7 by introducing a carrier gas 5 to a first chamber 8 accommodating the material powders 7 intermittently and mixing the material powders 7 and the carrier gas 5 to generate a first aerosol, introducing the first aerosol to a second chamber 9 to generate a second aerosol, and jetting the second aerosol to a third chamber 13 to form a film of the material powders 7.

摘要翻译： 根据本发明的成膜方法包括通过将载气5间歇地引入容纳材料粉末7的第一室8并混合材料粉末7和载气5以形成材料粉末7的膜来形成膜的步骤， 第一气溶胶，将第一气溶胶引入第二室9以产生第二气溶胶，并将第二气溶胶喷射到第三室13以形成材料粉末7的膜。