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    System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation
    1.
    发明授权
    System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
    用于避免，逆转和管理神经系统适应电刺激的系统和方法

    公开(公告)号：US08155750B2

    公开(公告)日：2012-04-10

    申请号：US12509340

    申请日：2009-07-24

    申请人： Kristen Jaax ,  Courtney Lane ,  Michael Moffitt ,  Andrew DiGiore ,  Mark Pierre ,  Kerry Bradley ,  Gregory Baldwin

    发明人： Kristen Jaax ,  Courtney Lane ,  Michael Moffitt ,  Andrew DiGiore ,  Mark Pierre ,  Kerry Bradley ,  Gregory Baldwin

    IPC分类号： A61N1/00

    CPC分类号： A61N1/37235 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37264

    摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.

    摘要翻译： 提供了一种用于编程神经刺激装置的方法和编程器。 该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形 根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置 刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

    SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION
    2.
    发明申请
    SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION 有权
    用于避免，反向和管理神经病学接受电子刺激的系统和方法

    公开(公告)号：US20100023090A1

    公开(公告)日：2010-01-28

    申请号：US12509340

    申请日：2009-07-24

    申请人： Kristen Jaax ,  Courtney Lane ,  Michael Moffitt ,  Andrew DiGiore ,  Mark Pierre ,  Kerry Bradley ,  Gregory Baldwin

    发明人： Kristen Jaax ,  Courtney Lane ,  Michael Moffitt ,  Andrew DiGiore ,  Mark Pierre ,  Kerry Bradley ,  Gregory Baldwin

    IPC分类号： A61N1/08

    CPC分类号： A61N1/37235 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37264

    摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.

    摘要翻译： 提供了一种用于编程神经刺激装置的方法和编程器。 该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形 根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置 刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

    METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE
    3.
    发明申请
    METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
    使用噪声共振方法来提高实际和有效的传输

    公开(公告)号：US20110009919A1

    公开(公告)日：2011-01-13

    申请号：US12501170

    申请日：2009-07-10

    申请人： Rafael Carbunaru ,  Michael Moffitt ,  Kristen Jaax ,  Andrew DiGiore ,  Courtney Lane

    发明人： Rafael Carbunaru ,  Michael Moffitt ,  Kristen Jaax ,  Andrew DiGiore ,  Courtney Lane

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0551 ,  A61N1/0529 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36128 ,  A61N1/36164

    摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.

    摘要翻译： 提供了向患者提供治疗的方法。 在一种方法中，患者具有应用亚阈值生物电刺激的神经元。 该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。 在另一种方法中，患者具有应用超临界生物电刺激的神经元。 该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。 另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。

    Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement
    6.
    发明授权
    Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement 有权
    使用脉冲放置避免频率锁定在多通道神经刺激系统中的方法

    公开(公告)号：US08543200B2

    公开(公告)日：2013-09-24

    申请号：US12550237

    申请日：2009-08-28

    申请人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K. L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    发明人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K. L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    IPC分类号： A61N1/00

    CPC分类号： A61N1/08 ,  A61N1/36071 ,  A61N1/36082

    摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.

    摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。

    METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT
    7.
    发明申请
    METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT 有权
    使用脉冲放置在多通道神经元系统中避免频率锁定的方法

    公开(公告)号：US20110054568A1

    公开(公告)日：2011-03-03

    申请号：US12550237

    申请日：2009-08-28

    申请人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K.L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    发明人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K.L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    IPC分类号： A61N1/08 ,  A61N1/36

    CPC分类号： A61N1/08 ,  A61N1/36071 ,  A61N1/36082

    摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.

    摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。

    METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS
    9.
    发明申请
    METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS 审中-公开
    同时刺激不同脑部目标的方法

    公开(公告)号：US20110160797A1

    公开(公告)日：2011-06-30

    申请号：US12976764

    申请日：2010-12-22

    申请人： James C. Makous ,  Courtney Lane ,  Kristen Jaax ,  Andrew DiGiore

    发明人： James C. Makous ,  Courtney Lane ,  Kristen Jaax ,  Andrew DiGiore

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36067 ,  A61N1/00 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36171

    摘要： A method for treating a patient having a dysfunction using a stimulation lead within the brain of a patient is provided. The stimulation lead carries a plurality of electrodes adjacent to a plurality of brain regions. Pulsed electrical waveforms having different sets of stimulation parameters are generated and then concurrently delivered to the plurality of electrodes, thereby concurrently stimulating the plurality of brain regions to treat the dysfunction.

    摘要翻译： 提供了一种使用患者脑内的刺激铅治疗具有功能障碍的患者的方法。 刺激引线携带与多个脑区域相邻的多个电极。 产生具有不同组刺激参数的脉冲电波形，然后同时传送到多个电极，从而同时刺激多个脑区域来治疗功能障碍。