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    Catheter system for the delivery of a low volume bolus
    3.
    发明授权
    Catheter system for the delivery of a low volume bolus 有权
    用于输送低体积推注的导管系统

    公开(公告)号：US06764461B2

    公开(公告)日：2004-07-20

    申请号：US09138131

    申请日：1998-08-21

    申请人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

    发明人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

    IPC分类号： A61F1320

    CPC分类号： A61M25/104 ,  A61M5/00 ,  A61M29/02 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1093

    摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.

    摘要翻译： 导管系统包括具有近端，远端和在其中延伸的内腔的导管。 给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。 本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。 本发明还包括向处理部位施用液体的方法。 导管的远端位于治疗部位附近。 导管通过将大量液体放置在内腔中来进行充电。产生正压力以将推注驱动到施用尖端以从导管的远端表达推注。

    Percutaneous myocardial revascularization growth factor mediums and method
    5.
    发明授权
    Percutaneous myocardial revascularization growth factor mediums and method 有权
    经皮心肌血运重建生长因子介质及方法

    公开(公告)号：US06238406B1

    公开(公告)日：2001-05-29

    申请号：US09516531

    申请日：2000-03-01

    申请人： Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang ,  Timothy J. Mickley

    发明人： Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang ,  Timothy J. Mickley

    IPC分类号： A61B1732

    CPC分类号： A61B17/32002 ,  A61B17/320758 ,  A61B17/3468 ,  A61B17/3478 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/320084 ,  A61B2018/00208 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61B2018/1861 ,  A61F2/2493 ,  A61M2025/0089

    摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.

    摘要翻译： 通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。 一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并具有流明和侧孔。 一种替代方法是利用不可生物降解的钉与流明和侧孔。 另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。 另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。 血管生成物质可以携带在可生物降解的粘合剂中。 通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。

    Delivery of a low volume liquid bolus
    9.
    发明授权
    Delivery of a low volume liquid bolus 失效
    输送低体积液体丸剂

    公开(公告)号：US07695455B2

    公开(公告)日：2010-04-13

    申请号：US10882397

    申请日：2004-07-02

    申请人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

    发明人： Timothy J. Mickley ,  Thomas R. Hektner ,  Louis Ellis ,  Gary L. Hendrickson

    IPC分类号： A61M5/178 ,  A61M5/24 ,  A61M5/00

    CPC分类号： A61M25/104 ,  A61M5/00 ,  A61M29/02 ,  A61M2025/0057 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1093

    摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen. A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.

    摘要翻译： 导管系统包括具有近端，远端和在其中延伸的内腔的导管。 给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。 本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。 本发明还包括向处理部位施用液体的方法。 导管的远端位于治疗部位附近。 通过将大量液体放置在管腔中来对导管进行充电。 产生正压力以将推注剂驱动到施用尖端以从导管的远端表达推注。