公开(公告)号：US08886288B2

公开(公告)日：2014-11-11

申请号：US13738621

申请日：2013-01-10

Applicant: MRI Interventions, Inc.

Inventor： Kimble L. Jenkins ,  Peter Piferi ,  Kamal Vij ,  Daniele Ghidoli ,  Jesse Flores

IPC: A61B5/05 ,  A61B5/06 ,  A61B5/055 ,  A61B5/00 ,  A61M25/01 ,  G01R33/28 ,  A61B5/042 ,  A61B18/18 ,  A61B5/053 ,  A61B18/02 ,  A61M5/00 ,  A61B19/00 ,  A61M29/00 ,  A61M25/00 ,  A61M25/06 ,  A61M25/09

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-compatible catheter includes an elongated flexible shaft having opposite distal and proximal end portions. A handle is attached to the proximal end portion and includes an actuator in communication with the shaft distal end portion that is configured to articulate the shaft distal end portion. The distal end portion of the shaft may include an ablation tip and includes at least one RF tracking coil positioned adjacent the ablation tip that is electrically connected to an MRI scanner. The at least one RF tracking coil is electrically connected to a circuit that reduces coupling when the at least one RF tracking coil is exposed to an MRI environment. Each RF tracking coil is a 1-10 turn solenoid coil, and has a length along the longitudinal direction of the catheter of between about 0.25 mm and about 4 mm.

Abstract translation: MRI兼容导管包括具有相对的远端和近端部分的细长柔性轴。 手柄附接到基端部，并且包括与轴远端部连通的致动器，该致动器构造成铰接轴远端部。 轴的远端部分可以包括消融尖端，并且包括邻近消融尖端定位的至少一个RF跟踪线圈，其被电连接到MRI扫描器。 当至少一个RF跟踪线圈暴露于MRI环境时，至少一个RF跟踪线圈电连接到减少耦合的电路。 每个RF跟踪线圈是1-10圈电磁线圈，并且沿着导管的纵向方向具有在约0.25mm和约4mm之间的长度。

公开(公告)号：US09055884B2

公开(公告)日：2015-06-16

申请号：US13717226

申请日：2012-12-17

Applicant: MRI Interventions, Inc.

Inventor： Peter Piferi ,  Kimble L. Jenkins ,  David John Sayler

IPC: A61B5/00 ,  A61B5/06 ,  A61B19/00 ,  G01R33/28 ,  G01R33/3415 ,  A61B18/00 ,  A61N1/05 ,  A61B5/055 ,  A61B17/00 ,  A61B17/34 ,  A61N1/36 ,  A61N1/372

CPC classification number: A61B5/062 ,  A61B5/004 ,  A61B5/0042 ,  A61B5/0044 ,  A61B5/055 ,  A61B5/0555 ,  A61B5/4836 ,  A61B5/4839 ,  A61B18/00 ,  A61B34/10 ,  A61B34/25 ,  A61B34/74 ,  A61B90/11 ,  A61B90/14 ,  A61B90/361 ,  A61B90/37 ,  A61B90/50 ,  A61B2017/00212 ,  A61B2017/00477 ,  A61B2017/00911 ,  A61B2017/3407 ,  A61B2017/3409 ,  A61B2034/101 ,  A61B2034/107 ,  A61B2034/252 ,  A61B2034/256 ,  A61B2090/103 ,  A61B2090/306 ,  A61B2090/3614 ,  A61B2090/373 ,  A61B2090/374 ,  A61B2090/3933 ,  A61B2090/3937 ,  A61B2090/395 ,  A61B2090/3954 ,  A61B2090/3983 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/36014 ,  A61N1/372 ,  G01R33/286 ,  G01R33/287 ,  G01R33/3415

Abstract: An MRI-guided interventional system includes a trajectory guide frame for guiding an interventional device with respect to a patient in an MRI-guided procedure and including a base, a platform, a targeting cannula, and a stabilizer mechanism. The platform is mounted on the base and includes a support table and a moving plate that is translatable relative to the support table and the base along a translational axis. The targeting cannula is mounted on the moving plate for movement therewith and includes an elongate guide bore defining a trajectory axis. The stabilizer mechanism is operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base. The frame is operable to translate the moving plate along the translational axis relative to the base to position the trajectory axis. The translational axis is transverse to the trajectory axis.

Abstract translation: MRI引导的介入系统包括用于在MRI引导过程中引导介入装置相对于患者的轨迹引导框架，并且包括基座，平台，靶向插管和稳定器机构。 平台安装在基座上并且包括支撑台和移动板，其可相对于支撑台和基座沿平移轴线平移。 靶向套管安装在移动板上以与其一起运动并且包括限定轨迹轴线的细长导向孔。 稳定器机构可操作以选择性地控制支撑台和移动板之间的运动，以使靶向套管相对于基座的位置稳定。 该框架可操作以使移动板沿相对于基座的平移轴平移以定位轨迹轴。 平移轴线横向于轨迹轴线。

公开(公告)号：US08768433B2

公开(公告)日：2014-07-01

申请号：US13723612

申请日：2012-12-21

Applicant: MRI Interventions, Inc.

Inventor： Kimble L. Jenkins ,  Peter Piferi ,  Kamal Vij

IPC: A61B5/05

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-guided medical device includes an elongated sheath, an elongated dilator, and an elongated needle. The sheath has a distal end, an opposite proximal end, and a central lumen extending between the proximal and distal ends. The sheath comprises MRI-compatible material and includes a tracking member located adjacent to the sheath distal end that is visible in an MRI image. The dilator comprises MRI-compatible material and is movably disposed within the sheath lumen. A distal end of the dilator is configured to extend outwardly from the sheath distal end and dilator includes at least one tracking member that is visible in an MRI image. The needle is movably disposed within the dilator lumen and is movable between stored and operative positions relative to the dilator. An RF shield may be coaxially disposed within the elongated sheath so as to surround a portion of the sheath central lumen.

Abstract translation: MRI引导的医疗装置包括细长护套，细长扩张器和细长针头。 鞘具有远端，相对的近端和在近端和远端之间延伸的中心腔。 护套包括与MRI相容的材料，并且包括位于MRI图像中可见的护套远端附近的跟踪构件。 扩张器包括与MRI相容的材料，并且可移动地设置在鞘腔内。 扩张器的远端构造成从护套远端向外延伸，并且扩张器包括在MRI图像中可见的至少一个跟踪构件。 针可移动地设置在扩张器腔内，并且可在相对于扩张器的存储和操作位置之间移动。 RF屏蔽件可以同轴地设置在细长护套内，以便围绕护套中心腔的一部分。

公开(公告)号：US20130123598A1

公开(公告)日：2013-05-16

申请号：US13738621

申请日：2013-01-10

Applicant: MRI Interventions, Inc.

Inventor： Kimble L. Jenkins ,  Peter Piferi ,  Kamal Vij ,  Daniele Ghidoli ,  Jesse Flores

IPC: A61B5/042 ,  A61B5/00 ,  A61B18/18 ,  A61B5/055

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-compatible catheter includes an elongated flexible shaft having opposite distal and proximal end portions. A handle is attached to the proximal end portion and includes an actuator in communication with the shaft distal end portion that is configured to articulate the shaft distal end portion. The distal end portion of the shaft may include an ablation tip and includes at least one RF tracking coil positioned adjacent the ablation tip that is electrically connected to an MRI scanner. The at least one RF tracking coil is electrically connected to a circuit that reduces coupling when the at least one RF tracking coil is exposed to an MRI environment. Each RF tracking coil is a 1-10 turn solenoid coil, and has a length along the longitudinal direction of the catheter of between about 0.25 mm and about 4 mm.

Abstract translation: MRI兼容导管包括具有相对的远端和近端部分的细长柔性轴。 手柄附接到基端部，并且包括与轴远端部连通的致动器，该致动器构造成铰接轴远端部。 轴的远端部分可以包括消融尖端，并且包括邻近消融尖端定位的至少一个RF跟踪线圈，其被电连接到MRI扫描器。 当至少一个RF跟踪线圈暴露于MRI环境时，至少一个RF跟踪线圈电连接到减少耦合的电路。 每个RF跟踪线圈是1-10圈电磁线圈，并且沿着导管的纵向方向具有在约0.25mm和约4mm之间的长度。

公开(公告)号：US10307220B2

公开(公告)日：2019-06-04

申请号：US15250590

申请日：2016-08-29

Applicant: MRI Interventions, Inc.

Inventor： Peter Piferi ,  Rajesh Pandey ,  Maxwell Jerad Daly ,  Kimble L. Jenkins

IPC: A61B90/11 ,  A61N1/05 ,  A61B17/17 ,  A61B17/16 ,  A61M25/02 ,  A61B17/00 ,  A61B6/03 ,  G01R33/28 ,  G01R33/48 ,  G01R33/565 ,  A61B6/00 ,  A61B5/055 ,  A61N1/372 ,  A61B90/00 ,  A61B34/20 ,  A61B90/10

Abstract: A trajectory frame for use with surgical navigation systems includes a base having a patient access aperture formed therein. A yoke is mounted to the base and is rotatable about a roll axis. A platform is mounted to the yoke and is rotatable about a pitch axis. An elongated guide is secured to the platform and includes opposite proximal and distal end portions and a bore that extends from the proximal end portion to the distal end portion. The guide is configured to removably receive various devices therein for quick release therefrom, including an optical tracking probe (which may be a universal tracker) detectable by a camera-based tracking system or an EM probe detectable by an EM navigation system, a microelectrode probe driver adapter, a drill guide and drill bit, skull fixation device and driver, and a catheter guide.

公开(公告)号：US09498290B2

公开(公告)日：2016-11-22

申请号：US14515105

申请日：2014-10-15

Applicant: MRI Interventions, Inc.

Inventor： Peter Piferi ,  Rajesh Pandey ,  Maxwell Jerad Daly ,  Kimble L. Jenkins

IPC: A61B19/00 ,  A61N1/05 ,  A61B17/17 ,  A61B17/16 ,  A61M25/02 ,  A61B17/00 ,  A61B6/03 ,  G01R33/28 ,  G01R33/48 ,  G01R33/565 ,  A61B6/00 ,  A61B5/055

CPC classification number: A61B90/11 ,  A61B5/055 ,  A61B6/032 ,  A61B6/5258 ,  A61B17/00234 ,  A61B17/1615 ,  A61B17/1695 ,  A61B17/1703 ,  A61B17/1739 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/103 ,  A61B2090/3983 ,  A61M25/02 ,  A61M2025/028 ,  A61M2210/0687 ,  A61M2210/0693 ,  A61N1/0534 ,  A61N1/372 ,  G01R33/286 ,  G01R33/4812 ,  G01R33/565

Abstract: A trajectory frame for use with surgical navigation systems includes a base having a patient access aperture formed therein. A yoke is mounted to the base and is rotatable about a roll axis. A platform is mounted to the yoke and is rotatable about a pitch axis. An elongated guide is secured to the platform and includes opposite proximal and distal end portions and a bore that extends from the proximal end portion to the distal end portion. The guide is configured to removably receive various devices therein for quick release therefrom, including an optical tracking probe (which may be a universal tracker) detectable by a camera-based tracking system or an EM probe detectable by an EM navigation system, a microelectrode probe driver adapter, a drill guide and drill bit, skull fixation device and driver, and a catheter guide.

Abstract translation: 与外科导航系统一起使用的轨迹框架包括其中形成有患者进入孔的底座。 轭架安装在基座上并可围绕辊轴线旋转。 平台安装在轭架上并可绕俯仰轴线旋转。 细长的导向件固定到平台上并且包括相对的近端部分和远端部分以及从近端部分延伸到远端部分的孔。 引导件被构造成可移除地接收其中的各种装置以从其中快速释放，包括可由基于照相机的跟踪系统或可由EM导航系统检测的EM探针可检测的光学跟踪探针（其可以是通用跟踪器），微电极探针 驱动器适配器，钻子引导器和钻头，头骨固定装置和驱动器以及导管引导件。

公开(公告)号：US20130131496A1

公开(公告)日：2013-05-23

申请号：US13749351

申请日：2013-01-24

Applicant: MRI Interventions, Inc.

Inventor： Kimble L. Jenkins ,  Peter Piferi ,  Kamal Vij ,  Daniele Ghidoli ,  Jesse Flores ,  Parag V. Karmarkar ,  Rajesh Pandey

IPC: A61B5/06 ,  A61B5/00 ,  A61B5/053 ,  A61B18/02 ,  A61M25/01 ,  A61M5/00 ,  A61B5/055 ,  A61B18/18

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-compatible catheter that reduces localized heating due to MR scanner-induced currents includes an elongated flexible shaft having a distal end portion and an opposite proximal end portion. A handle is attached to the proximal end portion and includes an electrical connector interface configured to be in electrical communication with an MRI scanner. One or more RF tracking coils are positioned adjacent the distal end portion of the shaft. Each RF tracking coil includes a conductive lead, such as a coaxial cable, that extends between the RF tracking coil and the electrical connector interface and electrically connects the RF tracking coil to an MRI scanner. In some embodiments of the present invention, the conductive lead has a length sufficient to define an odd harmonic/multiple of a quarter wavelength of the operational frequency of the MRI Scanner, and/or includes a series of pre-formed back and forth segments along its length.

Abstract translation: 减少由于MR扫描器感应电流引起的局部加热的MRI兼容导管包括具有远端部分和相对近端部分的细长柔性轴。 手柄附接到近端部分并且包括被配置为与MRI扫描仪电连通的电连接器接口。 一个或多个RF跟踪线圈定位在轴的远端部分附近。 每个RF跟踪线圈包括在RF跟踪线圈和电连接器接口之间延伸的导电引线，例如同轴电缆，并将RF跟踪线圈电连接到MRI扫描器。 在本发明的一些实施例中，导电引线具有足以限定MRI扫描器的工作频率的四分之一波长的奇次谐波/倍数的长度，和/或包括一系列预先形成的前后段 它的长度。

公开(公告)号：US20160361132A1

公开(公告)日：2016-12-15

申请号：US15250590

申请日：2016-08-29

Applicant: MRI Interventions, Inc.

Inventor： Peter Piferi ,  Rajesh Pandey ,  Maxwell Jerad Daly ,  Kimble L. Jenkins

IPC: A61B90/11 ,  A61B6/03 ,  A61N1/372 ,  A61B17/00 ,  A61N1/05 ,  A61B5/055 ,  A61B6/00

CPC classification number: A61B90/11 ,  A61B5/055 ,  A61B6/032 ,  A61B6/5258 ,  A61B17/00234 ,  A61B17/1615 ,  A61B17/1695 ,  A61B17/1703 ,  A61B17/1739 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/103 ,  A61B2090/3983 ,  A61M25/02 ,  A61M2025/028 ,  A61M2210/0687 ,  A61M2210/0693 ,  A61N1/0534 ,  A61N1/372 ,  G01R33/286 ,  G01R33/4812 ,  G01R33/565

Abstract: A trajectory frame for use with surgical navigation systems includes a base having a patient access aperture formed therein. A yoke is mounted to the base and is rotatable about a roll axis. A platform is mounted to the yoke and is rotatable about a pitch axis. An elongated guide is secured to the platform and includes opposite proximal and distal end portions and a bore that extends from the proximal end portion to the distal end portion. The guide is configured to removably receive various devices therein for quick release therefrom, including an optical tracking probe (which may be a universal tracker) detectable by a camera-based tracking system or an EM probe detectable by an EM navigation system, a microelectrode probe driver adapter, a drill guide and drill bit, skull fixation device and driver, and a catheter guide.

公开(公告)号：US20150031982A1

公开(公告)日：2015-01-29

申请号：US14515105

申请日：2014-10-15

Applicant: MRI Interventions, Inc.

Inventor： Peter Piferi ,  Rajesh Pandey ,  Maxwell Jerad Daly ,  Kimble L. Jenkins

IPC: A61B19/00 ,  A61B17/17 ,  A61B17/16 ,  A61M25/02 ,  A61B6/00 ,  A61B6/03 ,  G01R33/28 ,  G01R33/48 ,  G01R33/565 ,  A61N1/05 ,  A61B17/00

CPC classification number: A61B90/11 ,  A61B5/055 ,  A61B6/032 ,  A61B6/5258 ,  A61B17/00234 ,  A61B17/1615 ,  A61B17/1695 ,  A61B17/1703 ,  A61B17/1739 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/103 ,  A61B2090/3983 ,  A61M25/02 ,  A61M2025/028 ,  A61M2210/0687 ,  A61M2210/0693 ,  A61N1/0534 ,  A61N1/372 ,  G01R33/286 ,  G01R33/4812 ,  G01R33/565

Abstract: A trajectory frame for use with surgical navigation systems includes a base having a patient access aperture formed therein. A yoke is mounted to the base and is rotatable about a roll axis. A platform is mounted to the yoke and is rotatable about a pitch axis. An elongated guide is secured to the platform and includes opposite proximal and distal end portions and a bore that extends from the proximal end portion to the distal end portion. The guide is configured to removably receive various devices therein for quick release therefrom, including an optical tracking probe (which may be a universal tracker) detectable by a camera-based tracking system or an EM probe detectable by an EM navigation system, a microelectrode probe driver adapter, a drill guide and drill bit, skull fixation device and driver, and a catheter guide.

Abstract translation: 与外科导航系统一起使用的轨迹框架包括其中形成有患者进入孔的底座。 轭架安装在基座上并可围绕辊轴线旋转。 平台安装在轭架上并可绕俯仰轴线旋转。 细长的导向件固定到平台上并且包括相对的近端部分和远端部分以及从近端部分延伸到远端部分的孔。 引导件被构造成可移除地接收其中的各种装置以从其中快速释放，包括可由基于照相机的跟踪系统或可由EM导航系统检测的EM探针可检测的光学跟踪探针（其可以是通用跟踪器），微电极探针 驱动器适配器，钻子引导器和钻头，头骨固定装置和驱动器以及导管引导件。

公开(公告)号：US08825133B2

公开(公告)日：2014-09-02

申请号：US13749351

申请日：2013-01-24

Applicant: MRI Interventions, Inc.

Inventor： Kimble L. Jenkins ,  Peter Piferi ,  Kamal Vij ,  Daniele Ghidoli ,  Jesse Flores ,  Parag V. Karmarkar ,  Rajesh Pandey

IPC: A61B5/05 ,  A61B5/00 ,  A61B5/06 ,  A61B18/18 ,  A61B5/053 ,  G01R33/28 ,  A61M5/00 ,  A61B5/042 ,  A61B5/055 ,  A61B18/02 ,  A61M25/06 ,  A61B19/00 ,  A61M25/00 ,  A61M29/00 ,  A61M25/01 ,  A61M25/09

CPC classification number: A61B5/062 ,  A61B5/0044 ,  A61B5/042 ,  A61B5/0422 ,  A61B5/053 ,  A61B5/055 ,  A61B5/065 ,  A61B5/415 ,  A61B5/418 ,  A61B18/02 ,  A61B18/18 ,  A61B34/10 ,  A61B34/20 ,  A61B2090/365 ,  A61B2090/374 ,  A61B2090/3954 ,  A61M5/00 ,  A61M25/01 ,  A61M25/0127 ,  A61M29/00 ,  A61M2025/0089 ,  A61M2025/0166 ,  A61M2025/0681 ,  A61M2025/09175 ,  G01R33/286 ,  G01R33/287

Abstract: An MRI-compatible catheter that reduces localized heating due to MR scanner-induced currents includes an elongated flexible shaft having a distal end portion and an opposite proximal end portion. A handle is attached to the proximal end portion and includes an electrical connector interface configured to be in electrical communication with an MRI scanner. One or more RF tracking coils are positioned adjacent the distal end portion of the shaft. Each RF tracking coil includes a conductive lead, such as a coaxial cable, that extends between the RF tracking coil and the electrical connector interface and electrically connects the RF tracking coil to an MRI scanner. In some embodiments of the present invention, the conductive lead has a length sufficient to define an odd harmonic/multiple of a quarter wavelength of the operational frequency of the MRI Scanner, and/or includes a series of pre-formed back and forth segments along its length.

Abstract translation: 减少由于MR扫描器感应电流引起的局部加热的MRI兼容导管包括具有远端部分和相对近端部分的细长柔性轴。 手柄附接到近端部分并且包括被配置为与MRI扫描仪电连通的电连接器接口。 一个或多个RF跟踪线圈定位在轴的远端部分附近。 每个RF跟踪线圈包括在RF跟踪线圈和电连接器接口之间延伸的导电引线，例如同轴电缆，并将RF跟踪线圈电连接到MRI扫描器。 在本发明的一些实施例中，导电引线具有足以限定MRI扫描器的工作频率的四分之一波长的奇次谐波/倍数的长度，和/或包括一系列预先形成的前后段 它的长度。