公开(公告)号：US20110279935A1

公开(公告)日：2011-11-17

申请号：US13146423

申请日：2010-01-28

申请人： Masaharu Iwasa ,  Tomohiro Yamada

发明人： Masaharu Iwasa ,  Tomohiro Yamada

IPC分类号： H02H9/04

CPC分类号： H03H7/0107 ,  H03H7/427

摘要： There is disclosed a differential transmission circuit capable of realizing a high resistance to electrostatic breakdown without deteriorating a transmission signal. The differential transmission circuit includes ESD protection elements 5 and 6 connected between transmission lines 3 and 4 and a ground, respectively, a common mode filter 9 in which an inductor element 7 serially connected between the transmission lines 3 and a transmission line 10, and an inductor element 8 serially connected between the transmission line 4 and a transmission line 11 are magnetically coupled to each other, ESD protection diodes 12 and 13 of which cathodes are connected to the transmission lines 10 and 11, respectively, and anodes thereof are connected to grounds, respectively, and resistors 14 and 15 of which one side terminals are connected to the transmission lines 10 and 11, respectively, and the other side terminals thereof are connected to transmission lines 16 and 17, respectively. Resistance values of the resistors 14 and 15 are set to 10 to 15 ohms, respectively, electrostatic capacitance values of the ESD protection elements 5 and 6 are less than 0.3 pF, respectively, and a clip voltage of each of the ESD protection diodes 12 and 13 is set to a value less than 10 V.

摘要翻译： 公开了一种差分传输电路，其能够在不降低传输信号的情况下实现高静电击穿电阻。 差分传输电路包括分别连接在传输线3和4之间的ESD保护元件5和6和接地，共模滤波器9，其中串联连接在传输线3和传输线10之间的电感器元件7和 串联连接在传输线路4和传输线路11之间的电感器元件8彼此磁耦合，分别连接到传输线路10和11的阴极和其阳极的ESD保护二极管12和13连接到接地 ，电阻器14和15分别连接到传输线路10和11，其中一个侧面端子分别连接到传输线路10和11，并且其另一个侧面端子分别连接到传输线路16和17。 电阻器14和15的电阻值分别设置为10至15欧姆，ESD保护元件5和6的静电电容值分别小于0.3pF，并且每个ESD保护二极管12和 13设定为小于10V的值。

公开(公告)号：US08693151B2

公开(公告)日：2014-04-08

申请号：US13146423

申请日：2010-01-28

申请人： Masaharu Iwasa ,  Tomohiro Yamada

发明人： Masaharu Iwasa ,  Tomohiro Yamada

IPC分类号： H02H9/04

CPC分类号： H03H7/0107 ,  H03H7/427

摘要： A differential transmission circuit is capable of realizing a high resistance to electrostatic breakdown without deteriorating a transmission signal. The differential transmission circuit includes ESD protection elements connected between transmission lines and a ground, respectively, a common mode filter in which an inductor element is serially connected between transmission lines, and an inductor element serially connected between transmission lines are magnetically coupled to each other, ESD protection diodes of which cathodes are connected to transmission, respectively, and anodes thereof connected to grounds, respectively, and resistors of which one side terminals are connected to transmission lines, respectively, and the other side terminals thereof are connected to transmission lines, respectively. Resistance values of the resistors are set to 10 to 15 ohms, respectively, electrostatic capacitance values of the ESD protection elements are less than 0.3 pF, respectively, and a clip voltage of each of the ESD protection diodes is set to a value less than 10 V.

摘要翻译： 差分传输电路能够实现高抗静电击穿，而不会降低传输信号。 差分传输电路分别包括连接在传输线和接地之间的ESD保护元件，其中电感器元件串联连接在传输线之间的共模滤波器，串联连接在传输线之间的电感器元件彼此磁耦合， 分别连接到传输的ESD保护二极管和分别连接到接地的阳极和分别连接到传输线的电阻器和其它侧端子分别连接到传输线 。 电阻器的电阻值分别设定为10〜15欧姆，ESD保护元件的静电电容值分别小于0.3pF，并且每个ESD保护二极管的钳位电压设定为小于10的值 五

公开(公告)号：US08877519B2

公开(公告)日：2014-11-04

申请号：US12738228

申请日：2008-10-29

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01N33/553 ,  G01N21/55 ,  G01N21/27

CPC分类号： G01N21/554 ,  G01N21/27 ,  Y10S436/805

摘要： A chemical sensor element contains a resonator having a first reflector in which particles of a fine metal structure are arranged two-dimensionally and periodically is counterposed with interposition of a dielectric layer to a second reflector, wherein the resonance wavelength of a resonator in which the entire of the first reflector is replaced by a metal thin film having the same thickness as the metal fine structure is different from the surface plasmon resonance wavelength induced in the metal fine structure; and the mode of the surface plasmon resonance excited in the metal fine structure is coupled with the mode of the resonator in which the entire of the first reflector is replaced by the metal thin film.

摘要翻译： 化学传感器元件包括具有第一反射器的谐振器，其中精细金属结构的颗粒被二维地周期性布置，并且与第二反射器插入电介质层，其中整个谐振器的谐振波长 由具有与金属精细结构相同的厚度的金属薄膜替换为与金属精细结构中诱发的表面等离子体共振波长不同的金属薄膜; 并且在金属精细结构中激发的表面等离子体激元谐振的模式与谐振器的模式耦合，其中整个第一反射器被金属薄膜代替。

公开(公告)号：US08570464B2

公开(公告)日：2013-10-29

申请号：US12824067

申请日：2010-06-25

申请人： Tomohiro Yamada ,  Ryo Kuroda

发明人： Tomohiro Yamada ,  Ryo Kuroda

IPC分类号： G02F1/1335 ,  G02B5/22

CPC分类号： G02B5/1809 ,  G02B5/203

摘要： An optical filter includes a substrate, and a periodic structure in which a plurality of members formed of silicon are periodically arranged on a surface of the substrate. The filter selectively transmits light of a first wavelength included in light incident on the periodic structure in the direction of the substrate. The members are two-dimensionally arranged with a period of 400 nm to 500 nm. The dimension of the members in the direction parallel to the surface is of 120 nm to 160 nm. A local maximum value of the transmission spectrum of the first wavelength is within the range of 400 nm to 500 nm.

摘要翻译： 光学滤波器包括衬底，并且周期性结构，其中由硅形成的多个构件周期性地布置在衬底的表面上。 滤光器选择性地透射入射在周期性结构上的光在基板的方向上包括的第一波长的光。 构件以400nm至500nm的周期二维排列。 构件在平行于表面的方向上的尺寸为120nm至160nm。 第一波长的透射光谱的局部最大值在400nm至500nm的范围内。

公开(公告)号：US20130197009A1

公开(公告)日：2013-08-01

申请号：US13877358

申请日：2011-10-21

申请人： Yukitaka Ideyama ,  Sadao Kuromitsu ,  Takashi Furutani ,  Masayoshi Takeda ,  Satoshi Konagai ,  Tomohiro Yamada ,  Nobuaki Taniguchi ,  Yutaka Kondoh ,  Masaaki Hirano ,  Kazushi Watanabe ,  Takashi Sugane ,  Akio Kakefuda

发明人： Yukitaka Ideyama ,  Sadao Kuromitsu ,  Takashi Furutani ,  Masayoshi Takeda ,  Satoshi Konagai ,  Tomohiro Yamada ,  Nobuaki Taniguchi ,  Yutaka Kondoh ,  Masaaki Hirano ,  Kazushi Watanabe ,  Takashi Sugane ,  Akio Kakefuda

IPC分类号： C07D401/02 ,  C07D401/14 ,  C07D403/02

CPC分类号： C07D401/02 ,  A61K31/496 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  C07D403/02 ,  C07D403/12

摘要： [Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation[Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.

摘要翻译： 本发明的目的在于提供一种可用于治疗伴随雄激素受体突变的前列腺癌的新型抗癌药物。本发明人进行了关于雄激素相关疾病的全面研究， 雄激素药物变得无效。 结果发现，作为本发明的药物组合物的活性成分的化合物在人突变型雄激素受体（AR）中表现出对转录活化的抑制作用，并且在人体中具有优异的抗肿瘤作用 前列腺癌的小鼠，从而完成本发明。 因此，作为本发明的药物组合物的活性成分的化合物可用于一系列与前列腺癌有关的雄激素受体相关疾病。

公开(公告)号：US08368898B2

公开(公告)日：2013-02-05

申请号：US12852808

申请日：2010-08-09

申请人： Tomohiro Yamada

发明人： Tomohiro Yamada

IPC分类号： G01N21/55 ,  G02B5/26

CPC分类号： G02B5/008 ,  B82Y20/00 ,  G02B6/1226 ,  G02B6/3624

摘要： Provided is an optical apparatus having high durability, less optical absorption than a hole-type metal thin film filter, high transmittance and high reflectance, and variable optical characteristics. The apparatus includes: a dielectric substrate; a metal structure group including multiple metal structures two-dimensionally and discretely disposed at regular intervals; and a dielectric layer covering the metal structure group, in which: the metal structures have a first length equal to or shorter than a predetermined wavelength in a visible light region in one direction, and a second length equal to or shorter than the wavelength in a perpendicular direction; and the metal structures resonates with light entering the dielectric substrate or the dielectric layer, having a variable dielectric constant, to generate localized surface plasmon resonance on a surface of the metal structures to have a minimum transmittance or a maximum reflectance of the light having the wavelength.

摘要翻译： 提供一种具有高耐久性，比空穴型金属薄膜滤光器的光吸收性低，透光率高，反射率高，光学特性可变的光学装置。 该装置包括：电介质基片; 包括以规则间隔二维和离散地设置的多个金属结构的金属结构组; 以及覆盖所述金属结构体的介电层，其中：所述金属结构具有在一个方向上的可见光区域中等于或短于预定波长的第一长度，以及等于或短于一个方向上的波长的第二长度 垂直方向 并且金属结构与进入具有可变介电常数的电介质基板或电介质层的光谐振，以在金属结构的表面上产生局部表面等离子体共振，以具有波长最小的光的最小透射率或最大反射率 。

公开(公告)号：US08321573B2

公开(公告)日：2012-11-27

申请号：US11663068

申请日：2005-09-01

申请人： Keiji Hirao ,  Motoe Sakanaka ,  Tomohiro Yamada

发明人： Keiji Hirao ,  Motoe Sakanaka ,  Tomohiro Yamada

IPC分类号： G06F15/16

CPC分类号： H04M11/007 ,  H04L41/08 ,  H04L41/0806 ,  H04L41/0886 ,  H04M1/72533

摘要： A communication terminal includes a CPU (28). The CPU (28) issues to a router (16) a send request for requesting the router (16) to send an ask signal for repetitive responses to a server (14). Then, the ask signal is sent to the server (14) by the router (16), and a receive port is temporarily opened. From the server (14), a response signal is repeatedly sent in response to the ask signal. To the response signal, time information representative of a waiting time from receiving an ask signal to its reply is attached. A response signal sent back while the receive port is opened arrives at the communication terminal through the router (16), but a response signal sent back after the receive port is closed is discarded in the router (16). The CPU (28) repeatedly issues a send request to the router (16) regarding a time indicated by time information attached to the response signal lastly received as an issuance cycle (T).

摘要翻译： 通信终端包括CPU（28）。 CPU（28）向路由器（16）发出请求路由器（16）向服务器（14）发送重复响应的询问信号的发送请求。 然后，询问信号被路由器（16）发送到服务器（14），并且接收端口被暂时打开。 从服务器（14），响应于询问信号重复地发送响应信号。 对于响应信号，附加表示从接收询问信号到其答复的等待时间的时间信息。 在接收端口打开时发回的响应信号通过路由器（16）到达通信终端，但在接收端口关闭后发回的响应信号在路由器（16）中被丢弃。 CPU（28）重复向路由器（16）发出关于由附加到最后接收的作为发行周期（T）的响应信号的时间信息指示的时间的发送请求。

公开(公告)号：US08154722B2

公开(公告)日：2012-04-10

申请号：US11677890

申请日：2007-02-22

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01J3/44

CPC分类号： G01N21/554 ,  G01N2021/258

摘要： Even when only a few antigens exist in a specimen, a change in a dielectric constant and a change in an optical spectrum accompanied thereto in the periphery of a conductive member are made larger, so that sensing at high sensitivity can be performed. A structure including a protrusion including a dielectric material protruded on a substrate and a conductive member provided on a first surface of the protrusion, in which the maximum value of the cross-sectional area in the cross-section in parallel with a first surface of the conductive member is larger than the area of the first surface.

摘要翻译： 即使在试样中只存在少量抗原，导电性部件的周围的介电常数的变化和伴随其的光谱的变化也变大，可以进行高灵敏度的感测。 一种结构，其特征在于，具有包括突出在基板上的介电材料的突起和设置在所述突起的第一面上的导电性部件，所述突起的横截面积的最大值与所述突起的第一面平行的截面积的最大值 导电构件比第一表面的面积大。

公开(公告)号：US20120026504A1

公开(公告)日：2012-02-02

申请号：US13192921

申请日：2011-07-28

申请人： Tomohiro Yamada

发明人： Tomohiro Yamada

IPC分类号： G01B9/02 ,  H01S3/113 ,  H01S3/10

CPC分类号： G01B9/02091 ,  G01B9/02004 ,  H01S3/06791 ,  H01S3/08004 ,  H01S3/08059 ,  H01S3/10084 ,  H01S3/113 ,  H01S5/50 ,  H01S2301/04

摘要： A light source apparatus includes an optical resonator formed by an optical amplification medium and an optical switch. The optical switch includes a saturable absorber and changes its transmittance or reflectance when receiving an optical pulse emitted from a light irradiation source which includes a wavelength-tunable light source. The light source apparatus emits amplified light from the optical resonator in correspondence with the center wavelength of the optical pulse from the wavelength-tunable light source. The relationship between a length L and an effective refractive index n of the optical resonator and a repetition frequency f of the optical pulse satisfies a condition L (nL)/c.

摘要翻译： 光源装置包括由光放大介质和光开关构成的光谐振器。 光学开关包括可饱和吸收体，并在接收到包括波长可调光源的光照射源发射的光脉冲时，改变其透射率或反射率。 光源装置对应于来自波长可调光源的光脉冲的中心波长，从光谐振器发射放大的光。 光谐振器的长度L和有效折射率n之间的关系以及光脉冲的重复频率f满足条件L （nL）/ c。

公开(公告)号：US20110304853A1

公开(公告)日：2011-12-15

申请号：US13154127

申请日：2011-06-06

申请人： Tomohiro Yamada ,  Kentaro Furusawa

发明人： Tomohiro Yamada ,  Kentaro Furusawa

IPC分类号： G01B9/02 ,  H01S3/10

CPC分类号： G01B9/02007 ,  G01B9/02004 ,  G01B9/02027 ,  G01B9/02091 ,  H01S3/08013 ,  H01S3/083 ,  H01S3/10046 ,  H01S5/0085 ,  H01S5/0656 ,  H01S5/0657 ,  H01S5/06835 ,  H01S5/14 ,  H01S5/4012 ,  H01S5/4087

摘要： A light source apparatus includes a laser oscillator equipped with a first optical resonator, a plurality of second optical resonators including input portions respectively connected in parallel to the first optical resonator, a plurality of light extraction units configured to extract a light beam from an output portion of each second optical resonator, and a light multiplexing unit configured to multiplex the light beam extracted from each light extraction unit, wherein the light source apparatus causes the light multiplexing unit to output a multiplexed light beam passed through the plurality of second optical resonators, an optical member having refractive index dispersion and an optical amplification medium are disposed in each of the plurality of second optical resonators, and the optical amplification media of the plurality of second optical resonators are different from each other in maximum gain wavelength.

摘要翻译： 光源装置包括配备有第一光谐振器的激光振荡器，包括分别并联连接到第一光谐振器的输入部分的多个第二光谐振器，多个光提取单元，被配置为从输出部分 以及光复用单元，其被配置为对从每个光提取单元提取的光束进行多路复用，其中所述光源装置使所述光复用单元输出通过所述多个第二光谐振器的复用光束， 具有折射率色散的光学构件和光学放大介质设置在多个第二光学谐振器中的每一个中，多个第二光学谐振器的光学放大介质在最大增益波长方面彼此不同。