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公开(公告)号：US20150065517A1
公开(公告)日：2015-03-05
申请号：US14537317
申请日：2014-11-10
IPC分类号： C07D413/10 , A61K31/505 , A61K45/06 , C07D401/12 , A61K31/506 , C07D277/42 , A61K31/426 , C07D263/48 , A61K31/421 , A61K31/4439 , A61K31/444 , C07D213/74 , A61K31/4418 , C07D401/14 , A61K31/4545 , C07D237/20 , A61K31/50 , A61K31/501 , C07D213/72 , C07D413/14 , C07D239/42
CPC分类号： C07D413/10 , A61K31/421 , A61K31/426 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/72 , C07D213/73 , C07D213/74 , C07D213/76 , C07D237/20 , C07D239/42 , C07D263/48 , C07D277/42 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention provides organic compounds of the following structure; A-L1-B-C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.
摘要翻译： 本发明提供以下结构的有机化合物; A-L1-B-C-D-L2-E，其可用于治疗或预防动物，特别是人类中与DGAT1活性相关的病症或障碍。
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公开(公告)号：US20130018054A1
公开(公告)日：2013-01-17
申请号：US13614666
申请日：2012-09-13
IPC分类号： A61K31/444 , A61K31/505 , C07D401/12 , A61K31/506 , C07D277/42 , A61K31/426 , C07D263/48 , A61K31/421 , C07D213/74 , A61K31/4418 , A61K31/4439 , C07D413/12 , C07D237/20 , A61K31/50 , A61K31/501 , A61K31/497 , A61P3/10 , A61P3/04 , A61P9/12 , A61P3/06 , A61P9/04 , A61P9/10 , A61P35/00 , A61P17/10 , C07D239/42
CPC分类号： C07D413/10 , A61K31/421 , A61K31/426 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/72 , C07D213/73 , C07D213/74 , C07D213/76 , C07D237/20 , C07D239/42 , C07D263/48 , C07D277/42 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention provides organic compounds of the following structure; A-L1-B—C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.
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公开(公告)号：US20130018074A1
公开(公告)日：2013-01-17
申请号：US13614626
申请日：2012-09-13
IPC分类号： A61K31/4439 , A61P9/12 , A61P3/04 , C07D413/12 , A61P3/10
CPC分类号： C07D413/10 , A61K31/421 , A61K31/426 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/72 , C07D213/73 , C07D213/74 , C07D213/76 , C07D237/20 , C07D239/42 , C07D263/48 , C07D277/42 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The present invention provides organic compounds of the following structure; A-L1-B—C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.
摘要翻译： 本发明提供以下结构的有机化合物; A-L1-B-C-D-L2-E，其可用于治疗或预防动物，特别是人类中与DGAT1活性相关的病症或障碍。
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4.发明申请TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS 审中-公开四氢吡啶并吡啶和四氢吡啶并吡啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US20140349995A1
公开(公告)日：2014-11-27
申请号：US14455848
申请日：2014-08-08
申请人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian HURLEY , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
发明人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian HURLEY , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20150250767A1
公开(公告)日：2015-09-10
申请号：US14715594
申请日：2015-05-19
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/4245
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20130296377A1
公开(公告)日：2013-11-07
申请号：US13826725
申请日：2013-03-14
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Xue LIANG , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Xue LIANG , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： C07D491/048 , A61K31/4184 , C07D413/06 , A61K45/06 , C07D403/14 , C07D401/14 , A61K31/4439 , C07D403/06 , A61K31/423
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20160024079A1
公开(公告)日：2016-01-28
申请号：US14774430
申请日：2014-03-13
申请人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
发明人： Christopher Michael ADAMS , Charles BABU , Michael Paul CAPPARELLI , Jian DING , Takeru EHARA , Keith JENDZA , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Liang XUE , Nello MAINOLFI , James J. POWERS , Michael H. SERRANO-WU , Chun ZHANG
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
摘要翻译： 本发明提供了式（I）化合物：其中X为N或CH，Y为NH，O或S，制备这些化合物的方法及其作为因子B抑制剂用于治疗与补体相关的病症和疾病的用途 替代途径激活如年龄相关性黄斑变性，糖尿病性视网膜病变和相关眼科疾病。 本发明还提供药物组合物和药理活性剂的组合。
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8.发明申请TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS 有权四氢吡啶并吡啶和四氢吡啶并吡啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US20130184253A1
公开(公告)日：2013-07-18
申请号：US13553120
申请日：2012-07-19
申请人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian Hurley , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
发明人： Christopher Michael ADAMS , Veronique DARSIGNY , Alec Nathanson FLYER , Christine Fang GELIN , Timothy Brian Hurley , Nan JI , Rajeshri Ganesh KARKI , Toshio KAWANAMI , Erik MEREDITH , Chang RAO , Michael H. SERRANO-WU , Catherine Fooks SOLOVAY
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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