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公开(公告)号：US20080176898A1
公开(公告)日：2008-07-24
申请号：US11587318
申请日：2005-04-14
申请人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
发明人： Michael Harter , Frank Wunder , Lars Barfacker , Gunter Karig , Walter Hubsch , Hanna Tinel , Eva-Maria Becker
IPC分类号： A61K31/445 , C07D211/06 , A61K31/195 , A61P9/00 , C07C229/06
CPC分类号： C07D211/62 , C07C235/34 , C07C235/36 , C07D205/04 , C07D207/08 , C07D211/60
摘要： The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.
摘要翻译： 本发明涉及苯乙酰胺，其制备方法及其用于制备用于治疗和/或预防人和动物尤其是心血管疾病疾病的药物。
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公开(公告)号：US20060154912A1
公开(公告)日：2006-07-13
申请号：US10537623
申请日：2003-11-28
申请人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Harter , Jens Erguden , Frank Wunder , Hanna Tinel , Johannes Kobberling , Eva-Maria Becker , Klaus Munter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Barfacker , Walter Hubsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： A61K31/455 , A61K31/397 , A61K31/195 , A61K31/445
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
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![6-arylmethyl substituted pyrazolo[3,4-d]pyrimidines](/abs-image/US/2014/08/19/US08809348B2/abs.jpg.150x150.jpg)
公开(公告)号：US08809348B2
公开(公告)日：2014-08-19
申请号：US12580725
申请日：2009-10-16
申请人： Martin Hendrix , Lars Barfacker , Christine Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Christine Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , A61P25/28 , A61P25/18 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US20080255118A1
公开(公告)日：2008-10-16
申请号：US10586501
申请日：2004-12-31
IPC分类号： A61K31/5377 , A61K31/513 , C07D401/04 , A61P25/28 , C07D413/04
CPC分类号： C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D491/10
摘要： The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新颖的氰基嘧啶酮，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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5.发明申请Pyrimidinone derivaties as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权作为急性和慢性炎性，缺血和重塑过程的治疗剂的嘧啶酮衍生物公开(公告)号：US20060160801A1
公开(公告)日：2006-07-20
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allertheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allertheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , A61K31/513 , C07D413/14 , C07D403/14
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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公开(公告)号：US20100298221A1
公开(公告)日：2010-11-25
申请号：US12440725
申请日：2007-08-30
申请人： Heinrich Meier , Peter kolkhof , Axel Kretschmer , Arounarith Tuch , Lars Barfacker , Yolanda Cancho Grande
发明人： Heinrich Meier , Peter kolkhof , Axel Kretschmer , Arounarith Tuch , Lars Barfacker , Yolanda Cancho Grande
IPC分类号： A61K38/16 , C07D213/80 , C07D213/22 , A61K31/444 , A61K31/4412 , A61K31/546 , A61K31/585 , A61K31/55 , A61K31/551 , A61K31/60 , A61K31/4365 , A61K31/519 , A61P3/00 , A61P9/10 , A61P9/00
CPC分类号： C07D213/80
摘要： The present invention relates to novel 2-phenoxy-6-phenyl- and 2-phenoxy-6-pyridylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, especially of dyslipidemias, arteriosclerosis and heart failure.
摘要翻译： 本发明涉及新的2-苯氧基-6-苯基 - 和2-苯氧基-6-吡啶基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。
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公开(公告)号：US20080261990A1
公开(公告)日：2008-10-23
申请号：US11663813
申请日：2005-09-10
申请人： Elke Dittrich-Wengenroth , Lars Barfacker , Axel Kretschmer , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Hilmar Bischoff , Christian Pilger , Ulrich Rosentreter , Stephan Bartel , Klemens Lustig , Armin Kern , Dieter Lang , Marcus Bauser
发明人： Elke Dittrich-Wengenroth , Lars Barfacker , Axel Kretschmer , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Hilmar Bischoff , Christian Pilger , Ulrich Rosentreter , Stephan Bartel , Klemens Lustig , Armin Kern , Dieter Lang , Marcus Bauser
IPC分类号： A61K31/496 , C07D405/12 , A61K31/506 , C07D239/28 , A61K31/505
CPC分类号： C07D239/42 , C07D405/12
摘要： The present invention relates to novel pyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidemias, arteriosclerosis, coronary heart disease, thrombosis and metabolic syndrome.
摘要翻译： 本发明涉及新颖的嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防心血管疾病，特别是血脂异常，动脉硬化，冠心病，血栓形成和代谢综合征。
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公开(公告)号：US20080255202A1
公开(公告)日：2008-10-16
申请号：US11547974
申请日：2005-03-26
申请人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Nils Griebenow , Axel Kretschmer , Joachim Kruger , Elisabeth Woltering , Lars Barfacker , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Stephen Bartel , Christian Pilger , Ulrich Rosentreter , Klemens Lustig , Armin Kern , Dieter Lang
发明人： Hilmar Bischoff , Elke Dittrich-Wengenroth , Nils Griebenow , Axel Kretschmer , Joachim Kruger , Elisabeth Woltering , Lars Barfacker , Claudia Hirth-Dietrich , Peter Ellinghaus , Martin Raabe , Stephen Bartel , Christian Pilger , Ulrich Rosentreter , Klemens Lustig , Armin Kern , Dieter Lang
IPC分类号： A61K31/4427 , C07D271/06 , A61K31/4245 , C07D261/06 , A61K31/42 , C07D271/10 , C07D231/10 , C07D213/02 , A61P9/00 , A61K31/4155 , C07D277/20 , A61K31/427 , C07D249/08 , A61K31/4196 , C07D233/54
CPC分类号： C07D405/12 , C07D231/12 , C07D249/04 , C07D263/32 , C07D271/06 , C07D277/28 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
摘要翻译： 本申请涉及新的苯硫基乙酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管疾病，特别是血脂异常和动脉硬化。
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公开(公告)号：US20070105881A1
公开(公告)日：2007-05-10
申请号：US10559954
申请日：2004-06-16
申请人： Martin Hendrix , Lars Barfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Barfacker , Bettina Beyreuther , Ulrich Ebert , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Yan-Hong Liu , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/513 , C07D239/14
CPC分类号： C07D239/42 , C07D401/12 , C07D409/12
摘要： The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
摘要翻译： 本发明涉及式（I）的新型6-芳基氨基-5-氰基-4-嘧啶酮的制备方法及其用于制备用于提高记忆力的意识，浓度，学习能力和/或保持性的药物的用途 。 所述化合物（I）显示作为PDE9抑制剂的活性。
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公开(公告)号：US20060100207A1
公开(公告)日：2006-05-11
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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