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1.发明授权Substituted 2-(heteroaryl-2-propenyl)phenols useful as anti-inflammatory agents 失效取代的2-（杂芳基-2-丙烯基）酚可用作抗炎剂
公开(公告)号：US4778818A
公开(公告)日：1988-10-18
申请号：US39407
申请日：1987-04-17
申请人： Michael N. Chang , Norman P. Jensen , Milton L. Hammond , Robert A. Zambias , John McDonald , Kathleen M. Rupprecht
发明人： Michael N. Chang , Norman P. Jensen , Milton L. Hammond , Robert A. Zambias , John McDonald , Kathleen M. Rupprecht
IPC分类号： C07C43/225 , C07C43/23 , C07C45/44 , C07C45/68 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D207/34 , C07D307/79 , C07D311/58 , A61K31/40
CPC分类号： C07D307/79 , C07C255/00 , C07C43/225 , C07C43/23 , C07C45/68 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D311/58
摘要： Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
摘要翻译： 由肉桂酰卤与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代制备取代的肉桂基-2,3-二氢苯并呋喃和类似物。 发现这些化合物是有效的局部抗炎剂。
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2.发明授权Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents 失效取代的肉桂基-2,3-二氢苯并呋喃和类似物可用作消炎剂
公开(公告)号：US4686235A
公开(公告)日：1987-08-11
申请号：US764446
申请日：1985-08-12
申请人： Michael N. Chang , Norman P. Jensen , Milton L. Hammond , Robert A. Zambias , John McDonald , Kathleen M. Rupprecht
发明人： Michael N. Chang , Norman P. Jensen , Milton L. Hammond , Robert A. Zambias , John McDonald , Kathleen M. Rupprecht
IPC分类号： A61K31/05 , C07C43/225 , C07C43/23 , C07C45/44 , C07C45/68 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D307/79 , C07D311/58 , C07C39/21
CPC分类号： C07D307/79 , C07C255/00 , C07C43/225 , C07C43/23 , C07C45/68 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D311/58
摘要： Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
摘要翻译： 由肉桂酰卤与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代制备取代的肉桂基-2,3-二氢苯并呋喃和类似物。 发现这些化合物是有效的局部抗炎剂。
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3.发明授权Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents 失效取代的肉桂基-2,3-二氢苯并呋喃和类似物可用作抗炎剂
公开(公告)号：US4537903A
公开(公告)日：1985-08-27
申请号：US541200
申请日：1983-10-12
IPC分类号： C07C69/94 , A61K31/055 , A61K31/215 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61P29/00 , C07C27/00 , C07C39/21 , C07C39/373 , C07C41/00 , C07C43/225 , C07C43/23 , C07C43/295 , C07C45/00 , C07C45/44 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07C51/00 , C07C65/19 , C07C65/40 , C07C67/00 , C07C69/035 , C07C253/00 , C07C255/53 , C07C255/56 , C07C313/00 , C07C315/04 , C07C317/18 , C07C323/20 , C07C323/65 , C07D307/79 , C07D307/83 , C07D311/58
CPC分类号： C07D307/79 , C07C255/00 , C07C43/225 , C07C43/23 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D311/58
摘要： Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
摘要翻译： 由肉桂酰卤与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代制备取代的肉桂基-2,3-二氢苯并呋喃和类似物。 发现这些化合物是有效的局部抗炎剂。
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4.发明授权Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents 失效取代的5-羟基-2,3-二氢苯并呋喃及其类似物可用作抗炎剂
公开(公告)号：US4563476A
公开(公告)日：1986-01-07
申请号：US553668
申请日：1983-11-21
IPC分类号： A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61P29/00 , C07D307/79 , C07D311/58 , C07D333/00 , C07D409/12 , C07D311/04
CPC分类号： C07D307/79 , C07D311/58 , C07D409/12
摘要： Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted (5-hydroxy-2,3-dihydrobenzofuran-6-yl) formaldehyde or analog thereof with an aryl amine followed by reduction. These compounds were found to be potent topical anti-inflammatory agents.
摘要翻译： 由适当取代的（5-羟基-2,3-二氢苯并呋喃-6-基）甲醛或其类似物制备取代的5-羟基-2,3-二氢苯并呋喃和类似物如取代的6-羟基-2,3-二氢苯并吡喃 与芳基胺反应，然后还原。 发现这些化合物是有效的局部抗炎剂。
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5.发明授权Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzo-pyran and analogs thereof useful as anti-inflammatory agents 失效苯硫基甲基-6-羟基-2,3-二氢苯并吡喃及其类似物可用作抗炎剂
公开(公告)号：US4558067A
公开(公告)日：1985-12-10
申请号：US585070
申请日：1984-03-01
IPC分类号： C07D311/58 , C07D333/34 , A01N43/16 , C07D311/04
CPC分类号： C07D333/34 , C07D311/58
摘要： Phenylthiomethyl-6-hydroxy-2,3-dihydrobenzopyran and analogs thereof were prepared from an appropriate (6-hydroxy-2,3-dihydro-benzopyran-7-yl) formaldehyde or analog thereof with a substituted thiophenol. These compounds were found to be potent anti-inflammatory agents.
摘要翻译： 由适当的（6-羟基-2,3-二氢 - 苯并吡喃-7-基）甲醛或其类似物与取代的苯硫酚制备苯硫基甲基-6-羟基-2,3-二氢苯并吡喃及其类似物。 发现这些化合物是有效的抗炎剂。
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6.发明授权Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor 失效抗炎取代的2-苄基 - 巯基 - 咪唑和嘧啶衍生物组合物及其用途的方法
公开(公告)号：US4734421A
公开(公告)日：1988-03-29
申请号：US924391
申请日：1986-10-29
IPC分类号： C07D233/84 , C07D239/38 , C07D277/36 , C07D277/74 , C07D405/12
CPC分类号： C07D405/12 , C07D239/38 , C07D277/36 , C07D277/74
摘要： Substituted 2-benzyl-mercapto-imidazoles and analogs were prepared from the nucleophlic substitution of an appropriately substituted benzoxyacetate with a 2-imidazole mercapto anion or an analog thereof. These compounds were found to be anti-inflammatory agents.
摘要翻译： 由适当取代的苯氧基乙酸酯与2-咪唑巯基阴离子或其类似物的亲核取代制备取代的2-苄基 - 巯基 - 咪唑和类似物。 发现这些化合物是抗炎剂。
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公开(公告)号：US5939384A
公开(公告)日：1999-08-17
申请号：US936561
申请日：1992-09-03
摘要： Certain propanolamine compounds which have a cyclohexapeptidyl nucleus and which are found to have extremely active antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
摘要翻译： 描述了具有环己肽基核并且被发现具有非常活跃的抗生素活性的某些丙醇胺化合物，其物理性质适用于直接用于治疗组合物中。 还描述了其制备的新方法。
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8.发明授权Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase 失效新型7-芳酰基-4-羟基-3-甲基 - 苯并呋喃作为环加氧酶和5-脂氧合酶的双重抑制剂
公开(公告)号：US5006549A
公开(公告)日：1991-04-09
申请号：US356151
申请日：1989-05-24
IPC分类号： C12N9/99 , A61K31/34 , A61K31/343 , A61P29/00 , A61P43/00 , C07D307/79 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06
CPC分类号： C07D307/79 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06
摘要： Novel 7-Aroyl-4-Hydroxy-3-Methyl-Benzofurans of the following general formula (I) are disclosed: ##STR1##The compounds are found to be potent dual inhibitors of cyclooxygenase and 5-lipoxygenase.
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9.发明授权6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis 失效6-取代的5-羟基-2,3-二氢苯并呋喃作为白三烯生物合成的抑制剂
公开(公告)号：US4966907A
公开(公告)日：1990-10-30
申请号：US230825
申请日：1988-08-12
申请人： Charles G. Caldwell , Milton L. Hammond , Ihor E. Kopka , Stanley H. B. Wright , Robert A. Zambias
发明人： Charles G. Caldwell , Milton L. Hammond , Ihor E. Kopka , Stanley H. B. Wright , Robert A. Zambias
IPC分类号： C07D307/79
CPC分类号： C07D307/79
摘要： Novel position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
摘要翻译： 公开了新的位置-4和/或位置-6取代的5-羟基-2,3-二氢苯并呋喃以及下列通式（I）的类似物：（I）这些化合物被发现是白细胞三烯的有效抑制剂 生物合成。
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公开(公告)号：US5948753A
公开(公告)日：1999-09-07
申请号：US58657
申请日：1993-05-04
摘要： Certain propanolamine compounds are described which have a cyclohexapeptidyl nucleus and which possess antibiotic activity with physical properties suitable for direct use in therapeutic compositions. A process for their preparation is also described.
摘要翻译： 描述了具有环己基肽基核并且具有适于直接用于治疗组合物的物理性质的抗生素活性的某些丙醇胺化合物。 还描述了其制备方法。
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