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公开(公告)号：US5958976A
公开(公告)日：1999-09-28
申请号：US933571
申请日：1997-09-19
IPC分类号： A61K31/197 , A61K8/00 , A61K8/44 , A61K31/195 , A61K31/198 , A61P17/00 , A61Q17/00
CPC分类号： A61Q17/00 , A61K8/44 , A61K2800/75
摘要： The invention relates to topical cosmetic or pharmaceutical compositions comprising an anti-stinging effective amount of an amino acid selected from the group consisting of an amino butyric acid, glutamine, glycine, and derivatives thereof, or mixtures thereof, as well as methods of reducing or preventing stinging using such compositions.
摘要翻译： 本发明涉及局部化妆品或药物组合物，其包含抗刺痛有效量的氨基酸，其选自氨基丁酸，谷氨酰胺，甘氨酸及其衍生物，或其混合物，以及还原或 防止使用这种组合物刺痛。
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公开(公告)号：US6139855A
公开(公告)日：2000-10-31
申请号：US243362
申请日：1999-02-01
申请人： Gheorghe Cioca , Joseph Gubernick , Andrew J. Bevacqua , Nicolae Vrabie , Daniel H. Maes , Kenneth D. Marenus , Edward Pelle , Neelam Muizzuddin , Vasile Ionita-Manzatu , Mirela Cristina Ionita-Manzatu
发明人： Gheorghe Cioca , Joseph Gubernick , Andrew J. Bevacqua , Nicolae Vrabie , Daniel H. Maes , Kenneth D. Marenus , Edward Pelle , Neelam Muizzuddin , Vasile Ionita-Manzatu , Mirela Cristina Ionita-Manzatu
IPC分类号： A61K8/19 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/46 , A61K33/00 , A61K45/00 , A61K47/02 , A61Q19/00 , C02F1/00 , C02F1/461 , A61K9/10
CPC分类号： C02F1/4618 , A61K33/00 , C02F1/005 , C02F2103/026 , Y10S514/937
摘要： The invention relates to composition having enhanced biological activity, the compositions comprising at least one structured water. In particular, the compositions contain a combination of I and S waters and a biologically active agent, in which the activity of the agent is increased relative to its activity in a non-structured water composition.
摘要翻译： 本发明涉及具有增强的生物活性的组合物，所述组合物包含至少一种结构化水。 特别地，组合物含有I和S水的组合和生物活性剂，其中药物的活性相对于其在非结构化水组合物中的活性而增加。
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公开(公告)号：US06680062B2
公开(公告)日：2004-01-20
申请号：US09971561
申请日：2001-10-05
IPC分类号： A61K600
CPC分类号： A61Q19/00 , A61K8/35 , A61K8/368 , A61K8/41 , A61K8/73 , A61K8/97 , A61K8/9706 , A61K8/987 , A61K31/122 , A61K31/203 , A61K31/60 , A61K31/70 , A61K36/82 , A61K2800/59 , A61K2800/75 , Y10S514/887 , A61K2300/00
摘要： The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.
摘要翻译： 本发明涉及用于局部应用于患有红斑痤疮并用类视黄醇治疗的皮肤的化妆品或药物组合物。 用于治疗酒渣鼻的组合物包含用于治疗酒渣鼻的抗刺激成分和若干其它成分。 其他组分形成水杨酸，植物鞘氨醇，绿茶，桧醇，高戈贡提取物和多糖的混合物。 本发明还提供了一种降低由于患有红斑痤疮的皮肤所感受到的敏感性增加引起的皮肤刺激的方法。 其他成分可有效治疗红斑痤疮病症，特别是治疗红斑痤疮的毛细血管扩张症状。
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公开(公告)号：US20130095046A1
公开(公告)日：2013-04-18
申请号：US13441164
申请日：2012-04-06
IPC分类号： A61K36/324
CPC分类号： A61K36/324 , A61K8/361 , A61K8/4973 , A61K8/63 , A61K8/68 , A61K8/97 , A61K2800/75 , A61K2800/782 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： The invention relates to a method for improving skin lipid barrier function by applying to the skin a composition comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.
摘要翻译： 本发明涉及通过向皮肤施用包含有效量的蛋白酶抑制剂和细胞分化增强剂的组合物来改善皮肤脂质屏障功能的方法。 该组合物可用于促进皮肤脂质屏障修复并保持脂质屏障的完整性。 在这方面，组合物可以用于治疗和预防干性皮肤，以及相关的计时/原始老化条件，用于治疗和预防对皮肤的刺激，治疗和预防与紫外线相关的损伤 皮肤，并增强保持自鞣性。
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5.发明申请MICROCURRENT-GENERATING TOPICAL OR COSMETIC SYSTEMS, AND METHODS OF MAKING AND USING THE SAME 有权微电流产生的局部或化妆品系统及其制造和使用方法公开(公告)号：US20090270788A1
公开(公告)日：2009-10-29
申请号：US12388661
申请日：2009-02-19
申请人： Kenneth D. Marenus , George Cioca , Peter J. Lentini , Geoffrey Hawkins , Vasile Ionita-Manzatu , Liliana S. George , Mirela C. Ionita-Manzatu , Raffi Balian , Lavinia C. Popescu
发明人： Kenneth D. Marenus , George Cioca , Peter J. Lentini , Geoffrey Hawkins , Vasile Ionita-Manzatu , Liliana S. George , Mirela C. Ionita-Manzatu , Raffi Balian , Lavinia C. Popescu
CPC分类号： A61N1/303 , A61K8/0208 , A61K8/042 , A61K9/0009 , A61K9/0014 , A61K9/7023 , A61K2800/5424 , A61K2800/5426 , A61K2800/83 , A61N1/0436 , A61N1/044 , A61N1/0468 , A61N1/0492 , A61N1/328 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a topical or cosmetic system that includes a first element capable of acting as an electron donor and a second element capable of acting as an electron acceptor. Such first and second elements are spaced apart by a predetermined distance across a skin surface. The system also includes a third element extending over the predetermined distance across the skin surface, while the third element contains an electrically conductive medium for electrically connecting the first and second elements, thereby generating an electrical current that flows across the skin surface from the first element through the conductive medium to the second element in the absence of any power source. The present invention also relates to methods of using the above-described system for preventing or treating skin damage.
摘要翻译： 本发明涉及局部或化妆品系统，其包括能够充当电子给体的第一元件和能够充当电子受体的第二元素。 这样的第一和第二元件跨越皮肤表面隔开预定的距离。 该系统还包括在皮肤表面上延伸超过预定距离的第三元件，而第三元件包含用于电连接第一元件和第二元件的导电介质，由此产生从第一元件流过皮肤表面的电流 在没有任何电源的情况下通过导电介质到第二元件。 本发明还涉及使用上述系统来预防或治疗皮肤损伤的方法。
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公开(公告)号：US6066327A
公开(公告)日：2000-05-23
申请号：US14232
申请日：1998-01-27
IPC分类号： A61K8/00 , A61K8/04 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/44 , A61K8/49 , A61K8/67 , A61K8/96 , A61K8/97 , A61K31/122 , A61K31/355 , A61K31/375 , A61K36/53 , A61P17/00 , A61Q19/00 , A61Q19/08 , A61K6/00 , A61K7/42
摘要： The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof, (c) a butylated phenol, (d) a rosemary extract, and (e)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物组合物，所述组合物包含有效量的至少一种抗氧化剂，其选自（a）生育酚及其衍生物，（b）抗坏血酸和 衍生物，（c）丁基化苯酚，（d）迷迭香提取物和（e）泛醌及其衍生物。 该组合物可用于治疗和预防光老化症状。
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公开(公告)号：US08710034B2
公开(公告)日：2014-04-29
申请号：US13441164
申请日：2012-04-06
CPC分类号： A61K36/324 , A61K8/361 , A61K8/4973 , A61K8/63 , A61K8/68 , A61K8/97 , A61K2800/75 , A61K2800/782 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： The invention relates to a method for improving skin lipid barrier function by applying to the skin a composition comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.
摘要翻译： 本发明涉及通过向皮肤施用包含有效量的蛋白酶抑制剂和细胞分化增强剂的组合物来改善皮肤脂质屏障功能的方法。 该组合物可用于促进皮肤脂质屏障修复并保持脂质屏障的完整性。 在这方面，组合物可以用于治疗和预防干性皮肤，以及相关的计时/原始老化条件，用于治疗和预防对皮肤的刺激，治疗和预防与紫外线相关的损伤 皮肤，并增强保持自鞣性。
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公开(公告)号：US6136301A
公开(公告)日：2000-10-24
申请号：US865821
申请日：1997-05-30
IPC分类号： A61K8/37 , A61K8/63 , A61K8/68 , A61Q1/06 , A61Q19/00 , A61K7/021 , A61K7/00 , A61K7/025 , A61K7/06
CPC分类号： A61Q19/00 , A61K8/37 , A61K8/375 , A61K8/63 , A61K8/68 , A61Q19/001 , A61K2800/59
摘要： The invention relates to lipid mixture compositions comprising one or more cholesteryl esters in an amount of at least about 25% by weight of the composition, and less than about 5% by weight of sphingolipid, as well as cosmetic and pharmaceutical formulations for topical application to the lips containing the lipid mixture.
摘要翻译： 本发明涉及包含一种或多种胆固醇酯的脂质混合物组合物，其量为组合物的至少约25重量％，小于约5重量％的鞘脂，以及用于局部应用于 嘴唇含有脂质混合物。
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公开(公告)号：US6068848A
公开(公告)日：2000-05-30
申请号：US992128
申请日：1997-12-17
摘要： The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof,(c) a butylated phenol, (d)N-acetyl cysteine, (e)a rosemary extract, and (f)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.
摘要翻译： 本发明涉及用于局部施用于皮肤的化妆品或药物组合物，该组合物包含有效量的至少一种抗氧化剂，其选自（a）生育酚及其衍生物，（b）抗坏血酸和 衍生物，（c）丁基化苯酚，（d）N-乙酰半胱氨酸，（e）迷迭香提取物和（f）泛醌及其衍生物。 该组合物可用于治疗和预防光老化症状。
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10.发明授权Microcurrent-generating topical or cosmetic systems, and methods of making and using the same 有权微生物产生的局部或美容系统及其制造和使用方法公开(公告)号：US09566430B2
公开(公告)日：2017-02-14
申请号：US12388661
申请日：2009-02-19
申请人： Kenneth D. Marenus , George Cioca , Peter J. Lentini , Geoffrey Hawkins , Vasile Ionita-Manzatu , Liliana S. George , Mirela C. Ionita-Manzatu , Raffi Balian , Lavinia C. Popescu
发明人： Kenneth D. Marenus , George Cioca , Peter J. Lentini , Geoffrey Hawkins , Vasile Ionita-Manzatu , Liliana S. George , Mirela C. Ionita-Manzatu , Raffi Balian , Lavinia C. Popescu
IPC分类号： A61N1/30 , A61K8/02 , A61K8/04 , A61Q19/00 , A61Q19/08 , A61N1/32 , A61K9/00 , A61K9/70 , A61N1/04
CPC分类号： A61N1/303 , A61K8/0208 , A61K8/042 , A61K9/0009 , A61K9/0014 , A61K9/7023 , A61K2800/5424 , A61K2800/5426 , A61K2800/83 , A61N1/0436 , A61N1/044 , A61N1/0468 , A61N1/0492 , A61N1/328 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a topical or cosmetic system that includes a first element capable of acting as an electron donor and a second element capable of acting as an electron acceptor. Such first and second elements are spaced apart by a predetermined distance across a skin surface. The system also includes a third element extending over the predetermined distance across the skin surface, while the third element contains an electrically conductive medium for electrically connecting the first and second elements, thereby generating an electrical current that flows across the skin surface from the first element through the conductive medium to the second element in the absence of any power source. The present invention also relates to methods of using the above-described system for preventing or treating skin damage.
摘要翻译： 本发明涉及局部或化妆品系统，其包括能够充当电子给体的第一元件和能够充当电子受体的第二元素。 这样的第一和第二元件跨越皮肤表面隔开预定的距离。 该系统还包括在皮肤表面上延伸超过预定距离的第三元件，而第三元件包含用于电连接第一元件和第二元件的导电介质，由此产生从第一元件流过皮肤表面的电流 在没有任何电源的情况下通过导电介质到第二元件。 本发明还涉及使用上述系统来预防或治疗皮肤损伤的方法。
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