公开(公告)号：US20120059020A1

公开(公告)日：2012-03-08

申请号：US13319960

申请日：2009-05-29

申请人： Noboru Hattori ,  Kentaro Ueda ,  Makoto Akashima ,  Masamichi Takagi

发明人： Noboru Hattori ,  Kentaro Ueda ,  Makoto Akashima ,  Masamichi Takagi

IPC分类号： A61K31/505 ,  A61P11/00 ,  C07D239/34

CPC分类号： A61K31/505 ,  C07D239/34

摘要： Disclosed is a compound which has an inhibitory activity on plasminogen activator inhibitor-1 (PAI-1) and has a propanedioic acid structure represented by formula (1) [wherein R1 and R2 independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 4 carbon atoms; R3 represents a cyclohexyl group or a phenyl group (provide that the phenyl group may be substituted by a substituent selected from a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkoxy group having 1 to 4 carbon atoms, and a halogen atom); R4 represents a linear or branched alkyl group having 1 to 6 carbon atoms or a phenyl group (provide that the phenyl group may be substituted by a substituent selected from a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkoxy group having 1 to 4 carbon atoms, and a halogen atom); and n represents an integer of 1 to 8]. The compound is useful as a prophylactic or therapeutic agent for pulmonary fibrosis.

摘要翻译： 公开了具有对纤溶酶原激活物抑制剂-1（PAI-1）具有抑制活性并具有由式（1）表示的丙二酸结构的化合物[其中R1和R2独立地表示氢原子或具有 1至4个碳原子; R3表示环己基或苯基（提供苯基可以被选自具有1至4个碳原子的直链或支链烷基的取代基，具有1至4个碳原子的直链或支链烷氧基取代，以及 卤素原子）; R4表示具有1〜6个碳原子的直链或支链烷基或苯基（提供苯基可以被选自具有1至4个碳原子的直链或支链烷基的取代基取代，直链或支链烷氧基 具有1至4个碳原子的基团和卤素原子）; n表示1〜8的整数]。 该化合物可用作肺纤维化的预防或治疗剂。

公开(公告)号：US20090118314A1

公开(公告)日：2009-05-07

申请号：US12300270

申请日：2006-06-01

申请人： Keiji Wakabayashi ,  Michihiro Mutoh ,  Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima ,  Kentaro Ueda

发明人： Keiji Wakabayashi ,  Michihiro Mutoh ,  Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima ,  Kentaro Ueda

IPC分类号： A61K31/505 ,  C07D263/32 ,  A61P1/00 ,  A61K31/421 ,  C07D239/34 ,  C07D263/58 ,  A61K31/423

CPC分类号： C07D239/34 ,  A61K31/421 ,  A61K31/423 ,  A61K31/428 ,  A61K31/505 ,  C07D263/32 ,  C07D263/56 ,  C07D277/66

摘要： A compound having a sructure of propanedioic acid represented by the following formula (1): (1) (wherein the ring A represents oxazole or the like; R1 represents an alkyl group, a lower alkoxy group or the like; R2 and R3 represent a lower alkyl group or the like; m represents 0 or an integer of 1 to 4, and m pieces of R1 may be the same or different from each other; and W represents an integer of 3 to 5) is useful as an agent for preventing or treating a gastrointestinal polyp and/or a malignant tumor, or an agent for preventing metastasis thereof.

摘要翻译： 具有由下式（1）表示的丙二酸结构的化合物：（1）（其中环A表示恶唑等; R 1表示烷基，低级烷氧基等; R 2和R 3表示 低级烷基等; m表示0或1〜4的整数，m个R 1可以相同也可以不同，W表示3〜5的整数）可用作防止 或治疗胃肠息肉和/或恶性肿瘤，或用于预防其转移的药剂。

公开(公告)号：US07521563B2

公开(公告)日：2009-04-21

申请号：US11659810

申请日：2004-08-10

申请人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

发明人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

IPC分类号： C07D263/30 ,  C07D413/00 ,  C07D277/20 ,  A61K31/42 ,  A61K31/425

CPC分类号： C07D277/30 ,  C07D263/32 ,  C07D277/22

摘要： A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

摘要翻译： 抑制炎性细胞因子产生IL-6和/或TNFα的化合物，可用于预防或治疗诸如这些细胞因子参与的各种炎性疾病和自身免疫性疾病等疾病。 由下式（1）表示的异羟肟酸衍生物：（1）（其中A和B各自表示苯基等; n为1〜8的整数，Y为氧或硫）。 该化合物具有优异的白细胞介素-6和/或TNFα产生抑制活性，可用作各种炎性疾病，自身免疫性疾病等的治疗剂。

公开(公告)号：US20070208065A1

公开(公告)日：2007-09-06

申请号：US11659810

申请日：2004-08-10

申请人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

发明人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

IPC分类号： A61K31/426 ,  A61K31/421 ,  C07D277/30 ,  C07D263/34

CPC分类号： C07D277/30 ,  C07D263/32 ,  C07D277/22

摘要： A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

摘要翻译： 抑制炎性细胞因子产生IL-6和/或TNFα的化合物，可用于预防或治疗诸如这些细胞因子参与的各种炎性疾病和自身免疫性疾病等疾病。 由下式（1）表示的异羟肟酸衍生物：（1）（其中A和B各自表示苯基等; n为1〜8的整数，Y为氧或硫）。 该化合物具有优异的白细胞介素-6和/或TNFα产生抑制活性，可用作各种炎性疾病，自身免疫性疾病等的治疗剂。

公开(公告)号：US20100100886A1

公开(公告)日：2010-04-22

申请号：US12529367

申请日：2008-02-05

申请人： Masamichi Takagi ,  Masayuki Mizuno ,  Hiroaki Inoue

发明人： Masamichi Takagi ,  Masayuki Mizuno ,  Hiroaki Inoue

IPC分类号： G06F9/50

CPC分类号： G06F9/5027 ,  G06F11/1428 ,  G06F11/3419 ,  G06F11/3433 ,  G06F2209/483 ,  G06F2209/501

摘要： Even if a multiprocessor includes an uneven performance core, an inoperative core or a core that does not satisfy such a performance as designed but if the contrivance of task allocation can satisfy the requirement of an application to be executed, the multiple processors are shipped. In a task group allocation method for allocating, to a processor having a plurality of cores, task groups included in an application for the processor to execute, a calculation section measures performances and disposition patterns of the cores, generates a restricting condition associating the measured performances and disposition patterns of the cores with information indicating whether the application can be executed, and, with reference to the restricting condition, reallocates to the cores, the task groups that have previously been allocated to the cores.

摘要翻译： 即使多处理器包括不均衡的性能核心，不能满足设计性能的不工作核心或核心，但如果任务分配的设计能够满足执行应用程序的要求，则会发送多个处理器。 在用于将具有多个核心的处理器分配给应用程序中的处理器执行的任务组的任务组分配方法中，计算部分测量核心的性能和配置模式，产生将测量性能 以及具有指示是否可以执行应用的信息的核心的配置模式，并且参考限制条件将已经分配给核心的任务组重新分配给核心。

公开(公告)号：US09266543B2

公开(公告)日：2016-02-23

申请号：US13991245

申请日：2010-12-07

申请人： Masamichi Takagi

发明人： Masamichi Takagi

IPC分类号： B61L25/02 ,  G01S19/45 ,  G01S19/50

CPC分类号： B61L25/025 ,  B61L25/026 ,  B61L2205/04 ,  G01S19/45 ,  G01S19/50

摘要： A train protection device, which decides a position of an own train on track by using GPS satellites, includes: a GPS reception unit; a tachogenerator unit; a track-information storage unit; and a position decision unit. The position decision unit decides the position of the own train based on the GPS signal, the reception state value, the running distance from the reference position, the current speed, and the information of a track on which the own train runs. When the reception state value is equal to or larger than a threshold, the position decision unit decides a position as a current train position by adding, with respect to a forward direction of the track on which the own train runs, a correction value.

摘要翻译： 通过使用GPS卫星决定自己的列车在轨道上的位置的列车保护装置包括：GPS接收单元; 一个测速发电机组; 轨道信息存储单元; 和位置决定单元。 位置决定单元基于GPS信号，接收状态值，与参考位置的行驶距离，当前速度以及自身列车运行的轨道的信息来决定自身列车的位置。 当接收状态值等于或大于阈值时，位置决定单元通过相对于自身列车运行的轨道的前进方向加上校正值来确定作为当前列车位置的位置。

公开(公告)号：US08758741B2

公开(公告)日：2014-06-24

申请号：US11887445

申请日：2006-03-23

申请人： Masamichi Takagi ,  Takahisa Kogure ,  Naoki Wakisaka ,  Hiroaki Takaku ,  Katsumi Ajisaka ,  Tatsuo Miyazaki ,  Masao Hirayama

发明人： Masamichi Takagi ,  Takahisa Kogure ,  Naoki Wakisaka ,  Hiroaki Takaku ,  Katsumi Ajisaka ,  Tatsuo Miyazaki ,  Masao Hirayama

IPC分类号： A01N63/00 ,  C12N15/09 ,  C12N15/63 ,  C07H21/04

CPC分类号： C12P17/06 ,  C07D309/30 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12P7/26 ,  C12Y503/01009

摘要： A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose is synthesized from D-glucose, oligosaccharide, polysaccharide, starch and rice bran, using the transformant. A culture solution containing the 2-deoxy-scyllo-inosose is treated with a mixed bed or double bed type column comprising a hydrogen form of strong acidic cation exchange resin and an organic ion form of basic anion exchange resin. The 2-deoxy-scyllo-inosose as purified is reacted with trimethoxymethane to convert into 2-deoxy-scyllo-inosose dimethylketal, and the dimethylketal is crystallized and purified. Then, DOI is highly purified through hydrolyzing the dimethylketal in the presence of acid.

摘要翻译： 制备转化体至少将含有参与合成2-脱氧 - 青蟹肌糖的基因的基因表达盒插入大肠杆菌作为宿主细胞。 使用转化体从D-葡萄糖，寡糖，多糖，淀粉和米糠合成2-脱氧 - 青蟹肌糖。 含有2-脱氧 - 青蟹肌糖的培养液用含氢形式的强酸性阳离子交换树脂和有机离子形式的碱性阴离子交换树脂的混合床或双床型柱处理。 将纯化的2-脱氧 - 青蟹肌糖与三甲氧基甲烷反应以转化成2-脱氧 - 鲨糖醛糖二甲基缩酮，并将二甲基缩酮结晶并纯化。 然后，DOI通过在酸存在下水解二甲基缩酮而高度纯化。

公开(公告)号：US08140912B2

公开(公告)日：2012-03-20

申请号：US12447512

申请日：2007-10-19

申请人： Hiroaki Inoue ,  Masamichi Takagi ,  Masayuki Mizuno

发明人： Hiroaki Inoue ,  Masamichi Takagi ,  Masayuki Mizuno

IPC分类号： G06F11/00

CPC分类号： G06F11/0721 ,  G06F11/0751 ,  G06F11/2236

摘要： A semiconductor integrated circuit comprising a processor having an output signal of instruction log information and being operable in a program in memory is disclosed. The semiconductor integrated circuit comprises trace determination circuit for comparing an instruction code that corresponds to the instruction log information from a processor with an instruction code that is read from the memory to detect faults.

摘要翻译： 公开了一种半导体集成电路，其包括具有指令日志信息的输出信号并且可在存储器中的程序中操作的处理器。 半导体集成电路包括跟踪确定电路，用于将来自处理器的与指令日志信息相对应的指令代码与从存储器读取的指令代码进行比较以检测故障。

公开(公告)号：US20110131578A1

公开(公告)日：2011-06-02

申请号：US12629048

申请日：2009-12-02

申请人： Masamichi Takagi ,  Yoshiki Seo ,  Akio Yamada ,  Takeo Hosomi

发明人： Masamichi Takagi ,  Yoshiki Seo ,  Akio Yamada ,  Takeo Hosomi

IPC分类号： G06F9/46

CPC分类号： G06F9/5038

摘要： Systems and methods are disclosed to process streaming data units (tuples) for an application using a plurality of processing units, the application have a predetermined processing time requirement, by changing an operator-set applied to the tuple by a processing unit, on a tuple-by-tuple basis; estimating code requirement for potential operators based on processing unit capability; and assigning the potential operators to the processing units.

摘要翻译： 公开了系统和方法来处理使用多个处理单元的应用的流数据单元（元组），该应用具有预定的处理时间要求，通过在元组上改变由处理单元应用于元组的操作符集 元组 基于处理单元能力估算潜在运营商的代码要求; 并将潜在的操作者分配给处理单元。

公开(公告)号：US20110067015A1

公开(公告)日：2011-03-17

申请号：US12866219

申请日：2009-02-12

申请人： Masamichi Takagi ,  Junji Sakai

发明人： Masamichi Takagi ,  Junji Sakai

IPC分类号： G06F9/45

CPC分类号： G06F8/456

摘要： A program parallelization apparatus which generates a parallelized program of shorter parallel execution time is provided. The program parallelization apparatus inputs a sequential processing intermediate program and outputs a parallelized intermediate program. In the apparatus, a thread start time limitation analysis part analyzes an instruction-allocatable time based on a limitation on an instruction execution start time of each thread. A thread end time limitation analysis part analyzes an instruction-allocatable time based on a limitation on an instruction execution end time of each thread. An occupancy status analysis part analyzes a time not occupied by already-scheduled instructions. A dependence delay analysis part analyzes an instruction-allocatable time based on a delay resulting from dependence between instructions. A schedule candidate instruction select part selects a next instruction to schedule. An instruction arrangement part allocates a processor and time to execute to an instruction.

摘要翻译： 提供了一种生成并行执行时间较短并行程序的程序并行化装置。 程序并行化装置输入顺序处理中间程序并输出并行化的中间程序。 在该装置中，线程开始时间限制分析部分基于对每个线程的指令执行开始时间的限制来分析指令可分配时间。 线程结束时间限制分析部分基于对每个线程的指令执行结束时间的限制来分析指令可分配时间。 占用状态分析部分分析未被计划的指令占用的时间。 依赖延迟分析部分基于由指令之间的依赖导致的延迟来分析指令可分配时间。 时间表候选指令选择部分选择要调度的下一个指令。 指令排列部分分配处理器和执行指令的时间。