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公开(公告)号：US20080164200A1
公开(公告)日：2008-07-10
申请号：US12007158
申请日：2008-01-07
IPC分类号： B01D24/34
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/02 , B01D2321/10 , B01D2321/16 , B01D2321/2008 , B01D2321/2016 , B01D2321/2066 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L9/06 , B01L9/52 , B01L2200/025 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/0681 , B01L2300/0822 , B01L2300/0851 , B65B7/161 , B65B69/00 , G01N1/2813 , G01N27/22 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T29/49822 , Y10T29/53039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/12 , Y10T436/25375 , Y10T436/255
摘要： A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall of the holder. The inner fluid pervious medium is of low fluidic impedance relative to the outer fluid pervious medium. The filter assembly is designed for use in a separation housing that defines two flow paths between inlet and outlet, one directly through the filter and the other around the periphery of the filter. The inlet portion of the housing has a central inlet in a radially sloped surface that faces the filter collection site. A movable suction head is adapted to cooperate with the housing and the filter assembly.
摘要翻译： 一种用于从含有颗粒物质的液体（例如生物液体样品）分离和收集颗粒物质层（例如细胞）的过滤器组件。 过滤器组件具有保持器和邻接的内部和外部流体可透过介质。 外部液体可渗透介质附着到保持器的侧壁上。 内部液体可渗透介质相对于外部流体可透过介质具有低流体阻抗。 过滤器组件设计用于分离壳体，其限定入口和出口之间的两个流动路径，一个直接通过过滤器，另一个围绕过滤器的周边。 壳体的入口部分具有面向过滤器收集位置的径向倾斜表面的中心入口。 可移动的吸头适于与壳体和过滤器组件配合。
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公开(公告)号：US20080166801A1
公开(公告)日：2008-07-10
申请号：US12007157
申请日：2008-01-07
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/02 , B01D2321/10 , B01D2321/16 , B01D2321/2008 , B01D2321/2016 , B01D2321/2066 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L9/06 , B01L9/52 , B01L2200/025 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/0681 , B01L2300/0822 , B01L2300/0851 , B65B7/161 , B65B69/00 , G01N1/2813 , G01N27/22 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T29/49822 , Y10T29/53039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/12 , Y10T436/25375 , Y10T436/255
摘要： A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall of the holder. The inner fluid pervious medium is of low fluidic impedance relative to the outer fluid pervious medium. The filter assembly is designed for use in a separation housing that defines two flow paths between inlet and outlet, one directly through the filter and the other around the periphery of the filter. The inlet portion of the housing has a central inlet in a radially sloped surface that faces the filter collection site. A movable suction head is adapted to cooperate with the housing and the filter assembly.
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公开(公告)号：US07316779B2
公开(公告)日：2008-01-08
申请号：US10274380
申请日：2002-10-21
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/02 , B01D2321/10 , B01D2321/16 , B01D2321/2008 , B01D2321/2016 , B01D2321/2066 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L9/06 , B01L9/52 , B01L2200/025 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/0681 , B01L2300/0822 , B01L2300/0851 , B65B7/161 , B65B69/00 , G01N1/2813 , G01N27/22 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T29/49822 , Y10T29/53039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/12 , Y10T436/25375 , Y10T436/255
摘要： A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall of the holder. The inner fluid pervious medium is of low fluidic impedance relative to the outer fluid pervious medium. The filter assembly is designed for use in a separation housing that defines two flow paths between inlet and outlet, one directly through the filter and the other around the periphery of the filter. The inlet portion of the housing has a central inlet in a radially sloped surface that faces the filter collection site. A movable suction head is adapted to cooperate with the housing and the filter assembly.
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公开(公告)号：US6151161A
公开(公告)日：2000-11-21
申请号：US174140
申请日：1998-10-16
CPC分类号： G02B21/362 , G02B21/24
摘要： A system for facilitating microscope-based specimen analysis is disclosed. The system includes an improved optical microscope, which may be used, in one application, to analyze cell and tissue samples from specimens obtained from patients, to facilitate inspection of suspicious materials and identification of atypical or abnormal cells and further expert review. The system includes a motorized plate, an automatic focusing sub-system, an improved light source, an improved simple plug connector for direct hookup of the microscope to an external computer, and an electronic image capturing and analyzing sub-system for automatic scanning of the sample and for electronic capture and storage of images indicative of the specimen.
摘要翻译： 公开了一种促进基于显微镜的样本分析的系统。 该系统包括改进的光学显微镜，其可以在一个应用中用于分析从患者获得的样本的细胞和组织样品，以便于检查可疑物质和鉴定非典型或异常细胞并进一步专家评估。 该系统包括电动板，自动聚焦子系统，改进的光源，用于将显微镜直接连接到外部计算机的改进的简单插头连接器，以及用于自动扫描的外部计算机的电子图像捕获和分析子系统 样品和用于电子捕获和存储指示样品的图像。
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5.发明授权公开(公告)号：US07572638B2
公开(公告)日：2009-08-11
申请号：US10274366
申请日：2002-10-21
IPC分类号： G01N35/02
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/02 , B01D2321/10 , B01D2321/16 , B01D2321/2008 , B01D2321/2016 , B01D2321/2066 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L9/06 , B01L9/52 , B01L2200/025 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/0681 , B01L2300/0822 , B01L2300/0851 , B65B7/161 , B65B69/00 , G01N1/2813 , G01N27/22 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/04 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T29/49822 , Y10T29/53039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/12 , Y10T436/25375 , Y10T436/255
摘要： An automated system and method for individually processing multiple specimens of particulate matter-containing liquid in respective containers. The containers are transported seriatim along a processing path to present them to, at least, a preprocessing apparatus (e.g., a mixing head), and then to a specimen acquisition apparatus, which removes preprocessed specimen fluid from the container for subsequent analytical testing or evaluation. Each apparatus is actuated in response to presentation of a container thereto so as to carry out its respective operation independently. An exemplary system can include, in sequential order, stations for container loading and unloading, container uncapping and cap disposal, specimen mixing, filter loading, specimen acquisition (e.g., by aspiration, and then slide printing), filter disposal, and container resealing. The system is capable of unattended operation for many hours at a time, and can interface with an integrated data management system to provide fully integrated specimen and information management in a complete diagnostic laboratory system.
摘要翻译： 一种用于在相应容器中单独处理含有颗粒物质的液体的多个样品的自动化系统和方法。 容器沿着处理路径串联输送，至少提供给预处理设备（例如，混合头），然后到样品采集设备，其从容器中除去预处理的样品流体用于随后的分析测试或评价 。 每个装置响应于容器的呈现被致动，以便独立地执行其各自的操作。 示例性系统可以按顺序包括用于容器装载和卸载，容器开盖和盖处理，样品混合，过滤器装载，样品采集（例如通过抽吸，然后滑动打印），过滤器处理和容器再密封的站。 该系统能够一次无人值守的操作，并可与一个综合的数据管理系统进行接口，在完整的诊断实验室系统中提供完全集成的标本和信息管理。
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公开(公告)号：US07807476B2
公开(公告)日：2010-10-05
申请号：US12732078
申请日：2010-03-25
IPC分类号： G01N1/18
CPC分类号： B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/2041 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/50825 , B01L2300/042 , B01L2300/046 , B01L2300/0681 , B01L2400/049 , B65B7/161 , G01N1/2813 , G01N1/4077 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.
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公开(公告)号：US20080307904A1
公开(公告)日：2008-12-18
申请号：US11667253
申请日：2005-11-10
CPC分类号： G01N35/1004 , B01L3/0217 , B01L3/502 , B01L2200/026 , B01L2300/042 , B01L2300/046 , B01L2400/0487
摘要： Method and system for obtaining a liquid sample from a particulate matter-containing liquid in, e.g., a specimen container. A receptacle is used that has an inlet and a chamber for collecting the liquid sample. A discharge passage accommodates upward flow of liquid from the container. The discharge passage preferably has an upper discharge port, and at least one intake submerged in the liquid in the container. A flow-metering passage prevents particulate matter above a predetermined size from passing into the receptacle chamber. Liquid transfer commences after the receptacle inlet is placed in liquid-tight communication with the discharge port. Operation of mechanized system also is disclosed, as well as an arrangement and method for handling multiple receptacles at a liquid transfer station.
摘要翻译： 用于从例如样品容器中的含颗粒物质的液体中获得液体样品的方法和系统。 使用具有用于收集液体样品的入口和室的容器。 排出通道容纳来自容器的向上的液体流。 排出通道优选地具有上排出口，并且至少一个入口浸没在容器中的液体中。 流量计通道防止高于预定尺寸的颗粒物质进入容器室。 液体转移在容器入口与排放口液密连接后开始。 还公开了机械化系统的操作，以及用于在液体转移站处处理多个容器的装置和方法。
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公开(公告)号：US07771662B2
公开(公告)日：2010-08-10
申请号：US10122151
申请日：2002-04-15
IPC分类号： B01L3/02
CPC分类号： B01D61/18 , B01D61/22 , B01D63/08 , B01D65/08 , B01D2321/2041 , B01F7/00583 , B01F7/1695 , B01F13/002 , B01F13/04 , B01F13/045 , B01L3/502 , B01L3/50825 , B01L2300/042 , B01L2300/046 , B01L2300/0681 , B01L2400/049 , B65B7/161 , G01N1/2813 , G01N1/4077 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/021 , G01N35/1016 , G01N2001/1025 , G01N2001/2826 , G01N2035/00089 , G01N2035/00138 , G01N2035/0405 , G01N2035/0427 , G01N2035/0441 , G01N2035/0443 , G01N2035/0458 , G01N2035/0462 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.
摘要翻译： 一种基于小瓶的系统和方法，用于直接在小瓶中处理和处理含颗粒物质的液体样品。 包括搅拌器和颗粒物分离室的处理组件可释放地联接到小瓶盖的内部。 当小瓶打开以将样品插入其中时，加工组件保留在盖子上。 将特定外力施加到封闭的小瓶将处理组件从盖子上分离，使得当盖子随后被移除时，处理组件保留在小瓶中，以供自动或手动实验室设备访问。
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公开(公告)号：USD697517S1
公开(公告)日：2014-01-14
申请号：US29424364
申请日：2012-06-11
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公开(公告)号：US06535626B1
公开(公告)日：2003-03-18
申请号：US09483205
申请日：2000-01-14
IPC分类号： G06K900
CPC分类号： G06T7/0012
摘要： A specimen preview and inspection system is disclosed. The system beneficially includes a preview stage, which provides a set of biasing-information for preview by a technician before the technician formally screens the specimen. The preview stage enables the technician to conveniently review information pertinent to the specimen at issue. The preview stage may thereby bias, or channel, the technician's attention during screening toward diagnostically significant aspects of the specimen. The invention is particularly useful in the context of Pap smear screening, although the invention may extend to inspection of other types of specimens or samples as well.
摘要翻译： 公开了一种样本预览和检查系统。 该系统有利地包括一个预览阶段，该预览阶段在技术人员正式屏蔽样本之前提供一组偏好信息以供技术人员预览。 预览舞台使技术人员能够方便地查看与所述标本相关的信息。 因此，预览阶段可能会在筛选过程中偏向或引导技术人员对于标本诊断重要方面的关注。 本发明在Pap涂片筛选的上下文中是特别有用的，尽管本发明也可以扩展到其他类型的样品或样品的检查。
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