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    High-precision computer-aided microscope system
    1.
    发明授权
    High-precision computer-aided microscope system 有权
    高精度计算机辅助显微镜系统

    公开(公告)号：US6151161A

    公开(公告)日：2000-11-21

    申请号：US174140

    申请日：1998-10-16

    申请人： William J. Mayer ,  Norman J. Pressman ,  Richard A. Domanik

    发明人： William J. Mayer ,  Norman J. Pressman ,  Richard A. Domanik

    IPC分类号： G02B21/00 ,  G02B21/06 ,  G02B21/24 ,  G02B21/26 ,  G02B21/36

    CPC分类号： G02B21/362 ,  G02B21/24

    摘要： A system for facilitating microscope-based specimen analysis is disclosed. The system includes an improved optical microscope, which may be used, in one application, to analyze cell and tissue samples from specimens obtained from patients, to facilitate inspection of suspicious materials and identification of atypical or abnormal cells and further expert review. The system includes a motorized plate, an automatic focusing sub-system, an improved light source, an improved simple plug connector for direct hookup of the microscope to an external computer, and an electronic image capturing and analyzing sub-system for automatic scanning of the sample and for electronic capture and storage of images indicative of the specimen.

    摘要翻译： 公开了一种促进基于显微镜的样本分析的系统。 该系统包括改进的光学显微镜，其可以在一个应用中用于分析从患者获得的样本的细胞和组织样品，以便于检查可疑物质和鉴定非典型或异常细胞并进一步专家评估。 该系统包括电动板，自动聚焦子系统，改进的光源，用于将显微镜直接连接到外部计算机的改进的简单插头连接器，以及用于自动扫描的外部计算机的电子图像捕获和分析子系统 样品和用于电子捕获和存储指示样品的图像。

    System for simplifying the implementation of specified functions
    2.
    发明授权
    System for simplifying the implementation of specified functions 失效
    用于简化指定功能实现的系统

    公开(公告)号：US5930732A

    公开(公告)日：1999-07-27

    申请号：US529188

    申请日：1995-09-15

    申请人： Richard A. Domanik ,  Dennis W. Gruber ,  William J. Mayer

    发明人： Richard A. Domanik ,  Dennis W. Gruber ,  William J. Mayer

    IPC分类号： G02B21/36 ,  G05B19/10 ,  G06F3/033 ,  G05B19/045

    CPC分类号： G06F3/03543 ,  G02B21/365 ,  G05B19/106 ,  G05B2219/23045 ,  G05B2219/23387

    摘要： A machine, method and medium for implementing functions using an input device in a manner that enhances efficient operation of a mechanism capable of operating in at least two states. The functions are implemented via a convenient input device, such as a mouse. One or more specified actuators of the input device implement a given function when the mechanism is in a first state, while at least one of those actuators implements a different function when the mechanism is in a second state. In embodiments of the present invention contemplating that the mechanism is a microscope system, two states in which the microscope system is envisioned to operate are a scan state and a pause state. The scan state allows the microscope system to execute a pre-defined scan sequence, while the pause state allows the microscope system to pause from that sequence.

    摘要翻译： 一种机器，方法和介质，用于以增强能够在至少两种状态下操作的机构的有效操作的方式使用输入装置来实现功能。 这些功能通过方便的输入设备（如鼠标）来实现。 当机构处于第一状态时，输入装置的一个或多个指定的致动器实现给定的功能，而当机构处于第二状态时，这些致动器中的至少一个致动器执行不同的功能。 在本发明的实施例中，考虑到该机构是显微镜系统，其中设想显微镜系统的两种状态是扫描状态和暂停状态。 扫描状态允许显微镜系统执行预定义的扫描序列，而暂停状态允许显微镜系统从该顺序暂停。

    Dual chamber blood culture bottle with break seal
    3.
    发明授权
    Dual chamber blood culture bottle with break seal 失效
    双室血培养瓶具有断裂密封

    公开(公告)号：US5652143A

    公开(公告)日：1997-07-29

    申请号：US477656

    申请日：1995-06-07

    申请人： Peter P. Gombrich ,  Richard A. Domanik ,  William J. Mayer

    发明人： Peter P. Gombrich ,  Richard A. Domanik ,  William J. Mayer

    IPC分类号： B01L3/00 ,  C12M1/24 ,  C12M3/00 ,  B01L11/00

    CPC分类号： B01L3/502 ,  C12M23/08 ,  C12M23/22 ,  C12M23/34 ,  C12M23/38 ,  C12M33/04 ,  B01L2400/0644

    摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit including a syringe port with pin extensions is provided for receiving a blood sample simultaneously into two independent sample compartments. At least two culture chambers contain growth media, one culture chamber preferably containing an aerobic growth medium and another culture chamber preferably containing an anaerobic growth medium. The device is configured to isolate the sample vials and culture chambers from contaminants of the external environment. Downward pressure on the syringe port causes the pin extensions to breache the sample compartment walls and thereby releases the blood sample from one sample compartment into one culture chamber while simultaneously releasing the blood from the other sample compartment into the other culture chamber. In the preferred embodiment, outer walls of the device are constructed of transparent plastic so as to enable visual observance of microorganism growth in the respective culture chambers.

    摘要翻译： 一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。 提供包括具有销延伸部的注射器端口的集成单元，用于将血液样本同时接收到两个独立的样品室中。 至少两个培养室含有生长培养基，一个培养室优选含有需氧生长培养基，另一培养室优选含有厌氧生长培养基。 该装置被配置为将样品瓶和培养室与外部环境的污染物隔离。 注射器端口上的向下压力导致销延伸部破裂样品室壁，从而将血液样品从一个样品室释放到一个培养室中，同时将血液从另一个样品室释放到另一个培养室中。 在优选实施例中，该装置的外壁由透明塑料构成，以便可以观察各个培养室中的微生物生长。

    Dual chamber blood culture bottle with syringe capture and piston assembly
    4.
    发明授权
    Dual chamber blood culture bottle with syringe capture and piston assembly 失效
    双腔血培养瓶，注射器捕捉和活塞组装

    公开(公告)号：US5580786A

    公开(公告)日：1996-12-03

    申请号：US477655

    申请日：1995-06-07

    申请人： Peter P. Gombrich ,  Richard A. Domanik ,  William J. Mayer

    发明人： Peter P. Gombrich ,  Richard A. Domanik ,  William J. Mayer

    IPC分类号： B01L3/00 ,  C12M1/18 ,  C12M1/24 ,  C12M1/36

    CPC分类号： B01L3/502 ,  C12M23/08 ,  C12M23/34 ,  C12M33/04 ,  B01L2400/0644

    摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit is provided with a syringe port and a piston assembly for receiving a specimen syringe and for enabling a predetermined quantity of blood to be injected into two sample cups. Isolated media compartments contain growth media, one preferably containing an aerobic growth medium and another preferably containing an anaerobic growth medium. Once the blood specimen is fully injected into the sample cups, the sample cups are released into the media compartments, thereby enabling the blood specimens to mix with the respective growth media for testing. Further, means may also be provided to lock the syringe into the integral device in order to facilitate efficient disposal upon completion of testing. Additionally, in the preferred embodiment, outer walls of the device are constructed of transparent plastic so as to enable visual observance of microorganism growth in the respective culture chambers.

    摘要翻译： 一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。 集成单元设置有注射器端口和用于接收样本注射器的活塞组件，并且用于使预定量的血液能够注射到两个样品杯中。 分离的介质隔室含有生长培养基，优选含有需氧生长培养基，另一种优选含有厌氧生长培养基。 一旦血液样本被完全注射到样品杯中，样品杯被释放到介质室中，从而使得血液样本与相应的生长培养基混合以进行测试。 此外，还可以提供用于将注射器锁定到整体装置中的装置，以便在测试完成时促进有效的处置。 此外，在优选实施例中，该装置的外壁由透明塑料构成，以便能够在各培养室内观察微生物生长。

    Liquid Specimen Sampling System and Method
    5.
    发明申请
    Liquid Specimen Sampling System and Method 审中-公开
    液体样本取样系统及方法

    公开(公告)号：US20080307904A1

    公开(公告)日：2008-12-18

    申请号：US11667253

    申请日：2005-11-10

    申请人： Norman J. Pressman ,  William J. Mayer

    发明人： Norman J. Pressman ,  William J. Mayer

    IPC分类号： G01N1/14 ,  B65H1/00

    CPC分类号： G01N35/1004 ,  B01L3/0217 ,  B01L3/502 ,  B01L2200/026 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2400/0487

    摘要： Method and system for obtaining a liquid sample from a particulate matter-containing liquid in, e.g., a specimen container. A receptacle is used that has an inlet and a chamber for collecting the liquid sample. A discharge passage accommodates upward flow of liquid from the container. The discharge passage preferably has an upper discharge port, and at least one intake submerged in the liquid in the container. A flow-metering passage prevents particulate matter above a predetermined size from passing into the receptacle chamber. Liquid transfer commences after the receptacle inlet is placed in liquid-tight communication with the discharge port. Operation of mechanized system also is disclosed, as well as an arrangement and method for handling multiple receptacles at a liquid transfer station.

    摘要翻译： 用于从例如样品容器中的含颗粒物质的液体中获得液体样品的方法和系统。 使用具有用于收集液体样品的入口和室的容器。 排出通道容纳来自容器的向上的液体流。 排出通道优选地具有上排出口，并且至少一个入口浸没在容器中的液体中。 流量计通道防止高于预定尺寸的颗粒物质进入容器室。 液体转移在容器入口与排放口液密连接后开始。 还公开了机械化系统的操作，以及用于在液体转移站处处理多个容器的装置和方法。

    Dual chamber blood culture bottle with rotating inlet valve assembly
    7.
    发明授权
    Dual chamber blood culture bottle with rotating inlet valve assembly 失效
    双室血培养瓶具有旋转进气阀组件

    公开(公告)号：US5573951A

    公开(公告)日：1996-11-12

    申请号：US475380

    申请日：1995-06-07

    申请人： Peter P. Gombrich ,  Richard A. Domanik ,  William J. Mayer

    发明人： Peter P. Gombrich ,  Richard A. Domanik ,  William J. Mayer

    IPC分类号： B01L3/00 ,  C12M1/18 ,  C12M1/24 ,  C12M1/36

    CPC分类号： B01L3/502 ,  C12M23/08 ,  C12M23/22 ,  C12M23/34 ,  B01L2400/0644

    摘要： A multi-chambered blood culture device for simultaneously conducting two blood culture tests on a single blood sample. An integrated unit is provided with rotating blood inlet valve assembly for receiving a blood sample simultaneously into two independent sample vials. Independent culture chambers contain growth media, one culture chamber preferably containing an aerobic growth medium and another culture chamber preferably containing an anaerobic growth medium. The device is configured to isolate the sample vials and culture chambers from contaminants of the external environment. By rotating the blood inlet valve assembly, blood is simultaneously released from one sample vial into one culture chamber and from the other sample vial into the other culture chamber. Outer walls of the device are preferably constructed of a transparent plastic material so as to enable visual observance of microorganism growth in the respective culture chambers.

    摘要翻译： 一种多室血液培养装置，用于同时对单个血液样品进行两次血培养试验。 集成单元设置有旋转进血阀组件，用于将血液样本同时接收到两个独立的样品瓶中。 独立培养室含有生长培养基，一个培养室优选含有需氧生长培养基，另一培养室优选含有厌氧生长培养基。 该装置被配置为将样品瓶和培养室与外部环境的污染物隔离。 通过旋转进血阀组件，将血液从一个样品瓶同时释放到一个培养室中，并从另一个样品瓶中释放到另一个培养室中。 设备的外壁优选由透明塑料材料构成，以便能够在各个培养室中观察到微生物生长。