中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

8 records (took 0.014 seconds)

    NANOPARTICLE DRUG DELIVERY SYSTEM AND METHOD OF TREATING CANCER AND NEUROTRAUMA
    1.
    发明申请
    NANOPARTICLE DRUG DELIVERY SYSTEM AND METHOD OF TREATING CANCER AND NEUROTRAUMA 审中-公开
    纳米颗粒药物递送系统及治疗癌症和神经瘤的方法

    公开(公告)号：US20160206615A1

    公开(公告)日：2016-07-21

    申请号：US14914932

    申请日：2014-08-27

    Applicant: Northeastern University

    Inventor： Shifalika TANGUTOORI ,  Srinivas SRIDHAR

    IPC: A61K31/502 ,  A61K31/5025 ,  A61K45/06 ,  A61K9/127

    CPC classification number: A61K31/502 ,  A61K9/1272 ,  A61K31/4188 ,  A61K31/5025 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

    Abstract: The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the form of nanoparticles that provide efficient delivery of the inhibitor into cancer cells or other cells and release of the inhibitor within the cells. In treating cancer, the result is killing of tumor cells, whereas in treatment of neurotrauma and neurodegenerative disease, the result is preservation of cell function.

    Abstract translation: 本发明提供了用于聚（ADP-核糖）聚合酶（PARP）酶抑制剂的药物制剂。 该制剂可用于治疗和预防癌症以及治疗神经损伤和神经退行性疾病。 PARP抑制剂以纳米颗粒的形式递送，其提供抑制剂到癌细胞或其他细胞中的有效递送以及细胞内抑制剂的释放。 在治疗癌症方面，结果是杀死肿瘤细胞，而在治疗神经损伤和神经退行性疾病方面，其结果是保留细胞功能。

    Portable Brain and Vision Diagnostic and Therapeutic System
    4.
    发明申请
    Portable Brain and Vision Diagnostic and Therapeutic System 审中-公开

    公开(公告)号：US20190307350A1

    公开(公告)日：2019-10-10

    申请号：US16347049

    申请日：2017-11-02

    Applicant: Northeastern University

    Inventor： Srinivas SRIDHAR ,  Craig VERSEK ,  Peter BEX

    IPC: A61B5/0478 ,  A61B5/0484 ,  A61B5/00

    Abstract: A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) mode, and the device can be used for simultaneous stimulus display and recording with latency of less than 1 millisecond. The device also includes electrodes that allow rapid set-up and measurement with low impedance contact with the scalp. The device can also be used in conjunction with virtual reality or alternate reality environments.

    NOVEL SENSOR SYSTEM UTILIZING PIEZOELECTRIC MICROCANTILEVER COUPLED WITH RESONATING CIRCUIT
    6.
    发明申请
    NOVEL SENSOR SYSTEM UTILIZING PIEZOELECTRIC MICROCANTILEVER COUPLED WITH RESONATING CIRCUIT 有权
    利用谐振电路耦合的压电微型计算机的新型传感器系统

    公开(公告)号：US20160054329A1

    公开(公告)日：2016-02-25

    申请号：US14778779

    申请日：2014-04-08

    Applicant: NORTHEASTERN UNIVERSITY

    Inventor： Samira FAEGH ,  Nader JALILI ,  Srinivas SRIDHAR

    IPC: G01N33/66

    CPC classification number: G01N33/66 ,  G01G3/16 ,  G01N29/022 ,  G01N29/036 ,  G01N33/5438 ,  G01N2291/0257

    Abstract: An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer is deposited on a surface of the beam; an input configured to receive a voltage from a voltage source for applying voltage to the piezoelectric layer; and a resonating circuit including: the piezoelectric layer, configured as a capacitor of the resonant circuit; and one or more additional electrical elements; wherein the voltage source is configured to apply a first AC voltage under a first condition for actuating the microcantilever at a first mechanical resonating frequency of the microcantilever and a second AC voltage under a second condition for actuating the microcantilever at a second electrical resonating frequency of the resonating circuit. Method of using the sensor system is also described.

    Abstract translation: 描述了一种可互换的传感器系统，包括：一个微型悬臂梁，包括一个锚定在第一端的梁，该梁在另一端自由振动，其中压电层沉积在梁的表面上; 被配置为从电压源接收用于向所述压电层施加电压的电压的输入; 以及谐振电路，包括：所述压电层，被配置为所述谐振电路的电容器; 和一个或多个附加电气元件; 其中所述电压源被配置为在第一条件下施加第一AC电压，以在所述微悬臂梁的第一机械谐振频率下起动所述微悬臂梁，并且在第二条件下施加第二AC电压，以在所述第二状态下以所述微悬臂梁的第二电共振频率致动所述微悬臂梁 谐振电路。 还描述了使用传感器系统的方法。

    Nanoencapsulated Combination Drug Formulations
    7.
    发明申请
    Nanoencapsulated Combination Drug Formulations 有权

    公开(公告)号：US20210085619A1

    公开(公告)日：2021-03-25

    申请号：US17030286

    申请日：2020-09-23

    Applicant: Northeastern University

    Inventor： Paige BALDWIN ,  Srinivas SRIDHAR ,  Bijay SINGH

    IPC: A61K9/51 ,  A61K9/10

    Abstract: Pharmaceutical formulations (nanococktails) include two or more nanoparticulate delivery vehicles each including an active agent. The nanococktails can be formulated at any ratio of active agents by changing the ratio of nanoparticulate delivery vehicles in the nanococktail. The nanoparticulate delivery vehicles can have matched surface potential to prevent aggregation. The nanoparticulate delivery vehicles of the combined formulation are designed to provide each active agent with desired, preferably overlapping therapeutic windows and a specifically selected pharmacokinetic and pharmacodynamic profile when the nanococktail is administered to a subject. Each of the nanoparticulate delivery vehicles can be designed to enhance solubility, duration of action, targeting, stability, and to program release while preventing degradation of an active agent and preventing side effects, toxicity, and tolerability issues in a subject.

Patent Agency Ranking