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公开(公告)号：US20200237932A1
公开(公告)日：2020-07-30
申请号：US16850333
申请日：2020-04-16
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron SHABAT , Ronit SATCHI-FAINARO , Nir HANANYA , Ori GREEN , Tal EILON
IPC: A61K49/00 , C07H15/26 , C07F9/12 , C09B11/24 , C07D321/00 , C07F7/18 , C09B23/01 , C09B23/04 , C07F5/02 , C07F5/04 , C09B23/08 , C07F9/655 , C09K11/06 , C07H15/203
Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US20230265480A1
公开(公告)日：2023-08-24
申请号：US18184249
申请日：2023-03-15
Applicant: NEMIS Technologies AG , Ramot at Tel-Aviv University Ltd.
Inventor： Doron SHABAT , Michal Eli ROTH-KONFORTI , Nir HANANYA , Ori GREEN , Urs SPITZ , Lukas WICK , Julian IHSSEN , Raffael VORBERG , Riccardo CRIBIU , Zuzana BABJAKOVÀ , Chunyan YAO
Abstract: A method is for the detection of presence or absence, quantification, and identification of target microorganisms, such as bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence. The method include providing a medium with one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the dioxetane compound emits light, and detecting the emitted light.
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公开(公告)号：US20170014531A1
公开(公告)日：2017-01-19
申请号：US15124360
申请日：2015-03-13
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Ronit SATCHI-FAINARO , Doron SHABAT , Rachel BLAU , Yana EPSHTEIN , Hemda BAABUR-COHEN , Shiran FERBER , Orit REDY-KEISAR , Einat KISIN-FINFER
IPC: A61K49/00 , A61K31/337 , A61K47/48
CPC classification number: A61K49/0054 , A61K31/337 , A61K47/58 , A61K47/593 , A61K47/65 , A61K49/0032
Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
Abstract translation: 公开了可用于有机应用的聚合体系。 聚合体系包含荧光或荧光部分和治疗活性剂，各自连接到相同或不同的聚合物部分。 聚合物体系被设计成使得响应于化学事件产生荧光信号，优选在接触在患病组织或器官中过度表达的分析物（例如酶）时产生荧光信号。 还公开了可用于包含在这种聚合物体系中的探针，制备这种探针的方法和聚合物体系，以及其在诊断和/或治疗应用中的用途。
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公开(公告)号：US20210214766A1
公开(公告)日：2021-07-15
申请号：US17058623
申请日：2019-05-24
Applicant: NEMIS Technologies AG , Ramot at Tel-Aviv University Ltd.
Inventor： Doron SHABAT , Michal Eli ROTH-KONFORTI , Nir HANANYA , Ori GREEN , Urs SPITZ , Lukas WICK , Julian IHSSEN , Raffael VORBERG , Riccardo CRIBIU , Zuzana BABJAKOVÀ , Chunyan YAO
IPC: C12Q1/10 , C07D407/04 , C07D321/00 , C12Q1/44 , C12Q1/04 , C12Q1/14 , C12Q1/22 , C12Q1/54 , G01N21/76
Abstract: Dioxetane compounds can be used in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods. A method for the detection of a target analyte, a target microorganism or a target metabolite includes providing a medium including one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the compound emits light, and detecting the emitted light.
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公开(公告)号：US20210214607A1
公开(公告)日：2021-07-15
申请号：US17058453
申请日：2019-05-24
Applicant: NEMIS Technologies AG , Ramot at Tel-Aviv University Ltd.
Inventor： Julian IHSSEN , Urs SPITZ , Doron SHABAT , Ori GREEN , Nir HANANYA
IPC: C09K11/06 , C07F5/04 , C07D405/10 , C07D321/00 , G01N33/58 , G01N21/76
Abstract: Improved long wavelength-emitting chemiluminescent probes are easy to synthesize and are well-suited for both in vitro and in vivo applications, but are particularly well-suited for in vivo applications. The wavelengths of the emissions of the probes include those in the orange, red or NIR range. Dioxetane compounds and phenolic ester compounds are included.
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Patent Agency Ranking
6.发明申请ACTIVATABLE FLUOROGENIC COMPOUNDS AND USES THEREOF AS NEAR INFRARED PROBES 审中-公开可激活的荧光化合物及其作为近红外探针的用途公开(公告)号：US20160229840A1
公开(公告)日：2016-08-11
申请号：US15131129
申请日：2016-04-18
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron SHABAT , Ronit SATCHI-FAINARO
IPC: C07D401/14 , C07D213/30 , C07D213/85 , G01N33/52 , C07D213/71 , C07D209/12 , A61K49/00 , C07D209/08 , C07D213/76
CPC classification number: C07D401/14 , A61K47/558 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , C09B23/0066 , C09B23/086 , C09B23/12 , G01N33/52 , G01N33/582
Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
Abstract translation: 新的荧光化合物被设计成使得在化学事件上产生能够发射NIR光的化合物被产生。 这些化合物包含两个或多个含受体的部分和可裂解供体的部分，其完全是π-电子共轭并且使得不能使π-电子的离域化。 还公开了在使荧光化合物经历化学事件（例如去质子化）时产生的荧光化合物。 还公开了荧光化合物作为NIR探测的用于监测各种分析物的存在和/或水平的Turn-ON机制的用途。
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7.发明申请公开(公告)号：US20140010763A1
公开(公告)日：2014-01-09
申请号：US14027219
申请日：2013-09-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron SHABAT , Ronit Satchi-Fainaro
CPC classification number: C07D401/14 , A61K47/558 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , C09B23/0066 , C09B23/086 , C09B23/12 , G01N33/52 , G01N33/582
Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
Abstract translation: 新的荧光化合物被设计成使得在化学事件上产生能够发射NIR光的化合物被产生。 这些化合物包含两个或多个含受体的部分和可裂解供体的部分，其完全是π-电子共轭并且使得不能使π-电子的离域化。 还公开了在使荧光化合物经历化学事件（例如去质子化）时产生的荧光化合物。 还公开了荧光化合物作为NIR探测的用于监测各种分析物的存在和/或水平的Turn-ON机制的用途。
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公开(公告)号：US20230094870A1
公开(公告)日：2023-03-30
申请号：US17904527
申请日：2021-02-17
Applicant: Ramot at Tel-Aviv University Ltd. , The Board of Trustees of the Leland Stanford Junior University
Inventor： Doron SHABAT , Ori GREEN , Matthew BOGYO
IPC: C07D321/00 , C12Q1/18 , C12Q1/04
Abstract: Turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe eh are useful for determining the presence, or measuring the level, of Mycobacterium tuberculosis (Mtb)-specific protease in a sample, and for assessing the susceptibility of the Mtb to an antibiotic drug. determining the presence or measuring the level of Mycobacterium tuberculosis (Mtb)-specific protease in the sample can include contacting the sample with a certain compound, and imaging the sample to detect an emission of light.
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公开(公告)号：US20200078475A1
公开(公告)日：2020-03-12
申请号：US16687789
申请日：2019-11-19
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit SATCHI-FAINARO , Doron SHABAT , Rachel BLAU , Yana EPSHTEIN , Hemda BAABUR-COHEN , Shiran FERBER , Orit REDY-KEISAR , Einat KISIN-FINFER
IPC: A61K49/00 , A61K31/337 , A61K47/65 , A61K47/59 , A61K47/58
Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
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公开(公告)号：US20190290787A1
公开(公告)日：2019-09-26
申请号：US16072848
申请日：2017-01-24
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron SHABAT , Ronit SATCHI-FAINARO , Nir HANANYA , Ori GREEN , Tal EILON
Abstract: Dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes can be included in compositions. The chemiluminescence probes are useful for both diagnostics and in vivo imaging.
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