Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array
    3.
    发明申请
    Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array 审中-公开
    用于测量微阵列上的磁性纳米颗粒的面密度的传感器和方法

    公开(公告)号:US20060128035A1

    公开(公告)日:2006-06-15

    申请号:US11338022

    申请日:2006-01-24

    IPC分类号: G01N33/551 C12M1/34

    摘要: The present invention relates to a method and a device for magnetic detection of binding of biological molecules on a biochip. A magnetoresistive sensor device for measuring an areal density of magnetic nanoparticles on a micro-array, the magnetic nanoparticles (15) being directly or indirectly coupled to the target sample (11), is described. The magnetoresistive sensor device comprises a substrate (3) having attached thereto binding sites (9) able to selectively bind target sample (11), and a magnetoresistive sensor for detecting the magnetic field of the nanoparticles (15) coupled to the target sample. The magnetoresistive sensor comprises a plurality of magnetoresistive sensing elements (17, 19), the width and length dimensions of which are at least a factor 10 or more, preferably a factor 100 or more larger than the diameter of the nanoparticles (15). A corresponding method is described as well.

    摘要翻译: 本发明涉及生物芯片上的生物分子结合的磁检测方法和装置。 描述了用于测量微阵列上的磁性纳米颗粒的面密度的磁阻传感器装置,磁性纳米颗粒(15)直接或间接耦合到目标样品(11)。 磁阻传感器装置包括一个其上附着有能够选择性地结合目标样品(11)的结合位点(9)的基片(3),和用于检测耦合到目标样品的纳米颗粒(15)的磁场的磁阻传感器。 磁阻传感器包括多个磁阻感测元件(17,19),其宽度和长度尺寸至少为纳米颗粒(15)直径的10倍或更大,优选为100倍或更大。 还描述了相应的方法。

    Device for detecting a magnetic field
    5.
    发明授权
    Device for detecting a magnetic field 失效
    用于检测磁场的装置

    公开(公告)号:US6075361A

    公开(公告)日:2000-06-13

    申请号:US977983

    申请日:1997-11-25

    摘要: The device comprises a Wheatstone bridge with at least four magnetoresistive elements (1a, 1b, 1c, 1d) on a substrate (15), each magnetoresistive element comprising at least one sensitive portion (13) comprising successively a first ferromagnetic layer (19) having a magnetic easy axis (27) extending in a first direction, a non-magnetic layer (21) and a second ferromagnetic layer (23) having a magnetic easy axis (29) extending in a second direction that is different from the first direction. The sensitive portions (13) have mutually parallel sensitive directions that are parallel to a third direction (X). Each magnetoresistive element (1a, 1b, 1c, 1d) is associated with a current conductor (35a, 35b, 35c, 35d) provided in the immediate vicinity of that magnetoresistive element. The first direction (27) is canted through an acute angle with respect to the third direction (X), and the second direction (29) is canted in the opposite sense through an acute angle with respect to the third direction. Each one of the current conductors (35a, 35b, 35c, 35d) extends over at least a portion of its length in a fourth direction (Y) perpendicular to the third direction (X).

    摘要翻译: 该装置包括在基板(15)上具有至少四个磁阻元件(1a,1b,1c,1d)的惠斯通电桥,每个磁阻元件包括至少一个敏感部分(13),其连续地包括第一铁磁层(19) 沿第一方向延伸的易磁化轴(27),具有沿与第一方向不同的第二方向延伸的易磁化轴(29)的非磁性层(21)和第二铁磁层(23)。 敏感部分(13)具有平行于第三方向(X)的相互平行的敏感方向。 每个磁阻元件(1a,1b,1c,1d)与设置在该磁阻元件紧邻处的电流导体(35a,35b,35c,35d)相关联。 第一方向(27)相对于第三方向(X)倾斜成锐角,并且第二方向(29)以相对于第三方向的锐角以相反的方向倾斜。 电流导体(35a,35b,35c,35d)中的每一个在垂直于第三方向(X)的第四方向(Y)上在其长度的至少一部分上延伸。

    APPARATUS FOR THE PROCESSING OF SINGLE MOLECULES
    6.
    发明申请
    APPARATUS FOR THE PROCESSING OF SINGLE MOLECULES 审中-公开
    用于单分子加工的装置

    公开(公告)号:US20140349892A1

    公开(公告)日:2014-11-27

    申请号:US14345261

    申请日:2012-09-25

    IPC分类号: G01N33/487

    CPC分类号: G01N33/48721

    摘要: The invention relates to an apparatus(100) and a method for the processing of single molecules, particularly for the sensing or sequencing of single-stranded DNA. A bottom layer(110) and an electrically conductive top layer(120) with a first and a second slit(111,121), respectively, are disposed on top of each other such that an aperture(A) is formed by the slits. The slits(111,121) are preferably perpendicular to each other. An electrical circuit(140) may be connected to the top layer(120), allowing to sense single molecules that pass through the aperture(A).

    摘要翻译: 本发明涉及一种用于处理单分子的装置(100)和方法,特别是单链DNA的感测或测序。 具有第一和第二狭缝(111,121)的底层(110)和导电顶层(120)分别设置在彼此的顶部上,使得通过狭缝形成孔(A)。 狭缝(111,121)优选地彼此垂直。 电路140可以连接到顶层120,以允许感测穿过孔A的单分子。

    Storage system using superparamagnetic particles
    8.
    发明申请
    Storage system using superparamagnetic particles 审中-公开
    使用超顺磁性颗粒的储存系统

    公开(公告)号:US20060028748A1

    公开(公告)日:2006-02-09

    申请号:US10532914

    申请日:2003-10-08

    申请人: Reinder Coehoorn

    发明人: Reinder Coehoorn

    IPC分类号: G11B27/36

    CPC分类号: G11B5/855 G11B5/84

    摘要: An information carrier (10) has an information plane that has a pattern of superparamagnetic material constituting an array of storage locations (11). The presence of a specific superparamagnetic material (12R, 12G, 12B, 12Y) at the information plane represents a value of a storage location. The superparamagnetic materials have a specific response to a varying magnetic field, e.g. a known decay time. A storage unit has an interface surface (32) for cooperating with the information plane, and has coils (27) for generating the varying magnetic field. The interface surface has an array of magnetic sensor elements (24,25,26) each having a sensitive area for generating a read signal. A processing unit (33) detects said presence via the specific response by processing the read signal.

    摘要翻译: 信息载体(10)具有信息平面,该信息平面具有构成存储位置(11)阵列的超顺磁性材料的图案。 在信息平面处存在特定的超顺磁性材料(12R,12G,12B,12Y)表示存储位置的值。 超顺磁材料对变化的磁场具有特定的响应,例如 一个已知的衰变时间。 存储单元具有用于与信息平面配合的接口表面(32),并具有用于产生变化磁场的线圈(27)。 接口表面具有磁传感器元件阵列(24,25,26),每个磁传感器元件具有用于产生读信号的敏感区域。 处理单元(33)通过处理读取信号通过特定响应检测所述存在。

    Magnetoresistive sensing device, system and method for determining a density of magnetic particles in fluid
    10.
    发明授权
    Magnetoresistive sensing device, system and method for determining a density of magnetic particles in fluid 失效
    磁阻感测装置,用于确定流体中磁性颗粒密度的系统和方法

    公开(公告)号:US07106051B2

    公开(公告)日:2006-09-12

    申请号:US10498952

    申请日:2002-12-18

    摘要: The present invention relates to a magnetoresistive sensing device, a system and a method for determining a density of magnetic particles in a fluid. The magnetoresistive sensing device has a substrate (1) with a layer structure (2) for supporting a fluid (3). The layer structure has a first surface area (4) in a first level and a second surface area (5) in another second level and a magnetoresistive element (6) for detecting the magnetic field of at least one magnetic particle (7) in the fluid, the magnetoresistive element being positioned near a transition (8) between the first and second surface area and facing at least one of the surface areas. A corresponding system and method is described as well.

    摘要翻译: 本发明涉及一种用于确定流体中磁性颗粒的密度的磁阻感测装置,系统和方法。 磁阻感测装置具有用于支撑流体(3)的具有层结构(2)的基底(1)。 所述层结构具有第一层中的第一表面区域(4)和在另一第二层次中的第二表面区域(5)和用于检测所述至少一个磁性颗粒(7)的磁场的磁阻元件(6) 液体,磁阻元件位于第一和第二表面区域之间的过渡部分(8)附近并面向至少一个表面区域。 还描述了相应的系统和方法。