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公开(公告)号：US07917188B2
公开(公告)日：2011-03-29
申请号：US11912691
申请日：2006-04-21
IPC分类号： A61B5/05
CPC分类号： G01R33/5601 , G01R33/4804
摘要： A method for mapping a physico-chemical parameter using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging is used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
摘要翻译： 在磁共振成像中使用化学交换饱和转移造影剂映射物理化学参数的方法与仅具有一个可交换实体池的试剂一起使用。 质子池，通过应用两种不同的RF频率来预处理造影剂。
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公开(公告)号：US20080188738A1
公开(公告)日：2008-08-07
申请号：US11912691
申请日：2006-04-21
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , G01R33/4804
摘要： The invention relates to a method for mapping of a physico-chemical parameter such as pH, temperature, pO2 or metabolite concentration using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method is a modification of the known ratiometric method and may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
摘要翻译： 本发明涉及使用化学交换饱和转移造影剂在磁共振成像中映射物理化学参数如pH，温度，pO 2或代谢物浓度的方法。 该方法是已知比例法的修改，并且可以与仅具有一个可交换实体池的代理一起使用。 质子池，通过应用两种不同的RF频率来预处理造影剂。
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公开(公告)号：US20080193384A1
公开(公告)日：2008-08-14
申请号：US11912694
申请日：2006-04-21
IPC分类号： A61K49/10 , C07D403/14
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localised inflammation respectively.
摘要翻译： 本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。 这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。 特别是pH和温度映射可用于分别检测小癌病变和局部炎症。
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公开(公告)号：US08734761B2
公开(公告)日：2014-05-27
申请号：US11912694
申请日：2006-04-21
IPC分类号： A61B5/055
CPC分类号： A61K49/124 , A61K49/1812 , A61K49/1821
摘要： The invention provides MRI contrast agents which provide a high sensitivity and which have an optimised body retention time. These agents enable the mapping of the local pH, temperature, oxygen concentration or other metabolites in a patient's body by the use of Chemical Exchange Saturation Transfer (CEST). Particularly pH and temperature mapping are useful for the detection of small cancer lesions and localized inflammation respectively.
摘要翻译： 本发明提供了提供高灵敏度并且具有优化的身体保留时间的MRI造影剂。 这些试剂可以通过使用化学交换饱和转移（CEST）来测定患者体内的局部pH，温度，氧浓度或其他代谢物。 特别是pH和温度映射可用于分别检测小癌病变和局部炎症。
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5.发明授权公开(公告)号：US08306603B2
公开(公告)日：2012-11-06
申请号：US11912674
申请日：2006-04-25
申请人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
发明人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
IPC分类号： A61B5/05
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译： 本发明提供一种MRI成像方法。 通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少 人造物，如运动文物。
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公开(公告)号：US20080200799A1
公开(公告)日：2008-08-21
申请号：US11912674
申请日：2006-04-25
申请人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
发明人： Nicolaas Petrus Willard , Rene Theodorus Wegh , Jeroen Alphons Pikkemaat , Holger Gruell , Tobias Schaeffter , Rudolf Mathias Johannes Nicolaas Lamerichs
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , A61K49/124 , G01R33/5605
摘要： The present invention provides a method MRI imaging. By applying a time modulation to the contrast enhancement of an MRI contrast agent, the method according to the invention leads to images with improved signal-to-noise ratio in the contrast-enhanced areas, strongly suppressed unwanted signal in the unenhanced areas, and reduced artefacts, such as motion artefacts.
摘要翻译： 本发明提供一种MRI成像方法。 通过对MRI造影剂的对比度增强应用时间调制，根据本发明的方法导致对比度增强区域中具有改善的信噪比的图像，强烈地抑制未增强区域中的不需要的信号，并且减少 人造物，如运动文物。
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公开(公告)号：US09470609B2
公开(公告)日：2016-10-18
申请号：US13263446
申请日：2010-04-09
申请人： Reinhold Wimberger-Friedl , Nicolaas Petrus Willard , Ivo Godfried Jozef Camps , Markus Laubscher , Emiel Peeters , Oana Mihaela Piciu
发明人： Reinhold Wimberger-Friedl , Nicolaas Petrus Willard , Ivo Godfried Jozef Camps , Markus Laubscher , Emiel Peeters , Oana Mihaela Piciu
CPC分类号： G01N1/2813 , B01L3/5025 , B01L2200/026 , B01L2200/0642 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2400/0688 , G01N21/03 , G01N2021/0346 , Y10T29/49
摘要： Apparatus for producing thin layers of a fluid sample for analysis, has a two dimensional array of analysis chambers (45), and a branching pattern of entry channels (25) coupled to the array to enable the analysis chambers to be filled in parallel. The analysis chambers are planar with a height less than that of the entry channels so as to produce the thin layers when filled with the fluid sample. The array enables more spacers between chambers in a given area, so that variations in height of the chambers can be reduced, while still enabling fast filling of the chambers. The analysis chambers can be suitable for capillary filling by a specified fluid sample such as blood. A pattern of exit channels (35) can be coupled to the array. The entry and exit channels can form comb patterns, fingers of the comb patterns being interdigitated, and the analysis chambers being arranged between the interdigitated fingers of the comb patterns.
摘要翻译： 用于制造用于分析的流体样品的薄层的装置具有分析室（45）的二维阵列，以及耦合到阵列的入口通道（25）的分支图案，以使分析室能够被平行地填充。 分析室是平面的，其高度低于入口通道的高度，以便在填充流体样品时产生薄层。 该阵列使得在给定区域中的腔室之间具有更多的间隔物，使得可以减小腔室的高度变化，同时仍然能够快速填充腔室。 分析室可以适用于通过特定流体样品如血液进行毛细管填充。 出口通道（35）的图案可以耦合到阵列。 入口和出口通道可以形成梳状图案，梳状图案的指状物被指叉，并且分析室被布置在梳形图案的交叉指状物之间。
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公开(公告)号：US08662080B2
公开(公告)日：2014-03-04
申请号：US13538071
申请日：2012-06-29
申请人： Peter Chi Fai Ho , Cornelis Petrus Hendriks , Rudolf Maria Jozef Voncken , Willem Potze , Joyce Van Zanten , Nicolaas Petrus Willard , Mareike Klee
发明人： Peter Chi Fai Ho , Cornelis Petrus Hendriks , Rudolf Maria Jozef Voncken , Willem Potze , Joyce Van Zanten , Nicolaas Petrus Willard , Mareike Klee
IPC分类号： A61M16/06
CPC分类号： A61M16/0875 , A61M16/0057 , A61M16/06 , A61M16/0616 , A61M16/0622 , A61M16/0633 , A61M16/0666 , A61M16/0683 , A61M2210/0618
摘要： A seal for a respiratory mask that includes a first end portion adapted to be coupled to a mask shell, a second end portion for sealing engagement with a face of a patient, and a sidewall extending between the first end portion and the second end portion. At least a portion of the second end portion includes a textured area having a predetermined pattern. The area of increased surface roughness provides the patient contacting portion of the seal with a silky feeling to maximize patient comfort and the effectiveness of the seal without impairing the sealing ability.
摘要翻译： 一种用于呼吸面罩的密封件，其包括适于联接到掩模壳体的第一端部部分，用于与患者的面部密封接合的第二端部部分以及在所述第一端部部分和所述第二端部部分之间延伸的侧壁。 第二端部的至少一部分包括具有预定图案的纹理化区域。 增加表面粗糙度的区域使密封件的患者接触部分具有柔滑的感觉，以最大限度地提高患者的舒适性和密封的有效性而不损害密封能力。
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公开(公告)号：US20120225446A1
公开(公告)日：2012-09-06
申请号：US13263446
申请日：2010-04-09
申请人： Reinhold Wimberger-Friedl , Nicolaas Petrus Willard , Ivo Godfried Jozef Camps , Markus Laubscher , Emiel Peeters , Oana Mihaela Piciu
发明人： Reinhold Wimberger-Friedl , Nicolaas Petrus Willard , Ivo Godfried Jozef Camps , Markus Laubscher , Emiel Peeters , Oana Mihaela Piciu
CPC分类号： G01N1/2813 , B01L3/5025 , B01L2200/026 , B01L2200/0642 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2400/0688 , G01N21/03 , G01N2021/0346 , Y10T29/49
摘要： Apparatus for producing thin layers of a fluid sample for analysis, has a two dimensional array of analysis chambers (45), and a branching pattern of entry channels (25) coupled to the array to enable the analysis chambers to be filled in parallel. The analysis chambers are planar with a height less than that of the entry channels so as to produce the thin layers when filled with the fluid sample. The array enables more spacers between chambers in a given area, so that variations in height of the chambers can be reduced, while still enabling fast filling of the chambers. The analysis chambers can be suitable for capillary filling by a specified fluid sample such as blood. A pattern of exit channels (35) can be coupled to the array. The entry and exit channels can form comb patterns, fingers of the comb patterns being interdigitated, and the analysis chambers being arranged between the interdigitated fingers of the comb patterns.
摘要翻译： 用于生产用于分析的流体样品的薄层的装置具有分析室（45）的二维阵列，以及耦合到阵列的入口通道（25）的分支图案，以使分析室能够被平行地填充。 分析室是平面的，其高度低于入口通道的高度，以便在填充流体样品时产生薄层。 该阵列使得在给定区域中的腔室之间具有更多的间隔物，使得可以减小腔室的高度变化，同时仍然能够快速填充腔室。 分析室可以适用于通过特定流体样品如血液进行毛细管填充。 出口通道（35）的图案可以耦合到阵列。 入口和出口通道可以形成梳状图案，梳状图案的指状物被指叉，并且分析室被布置在梳形图案的交叉指状物之间。
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公开(公告)号：US09827351B2
公开(公告)日：2017-11-28
申请号：US14127508
申请日：2012-06-29
申请人： Dirk Burdinski , Joyce Van Zanten , Lucas Johannes Anna Maria Beckers , Cornelis Petrus Hendriks , Willem Franke Pasveer , Nicolaas Petrus Willard , Mareike Klee , Biju Kumar Sreedharan Nair , David Smith
发明人： Dirk Burdinski , Joyce Van Zanten , Lucas Johannes Anna Maria Beckers , Cornelis Petrus Hendriks , Willem Franke Pasveer , Nicolaas Petrus Willard , Mareike Klee , Biju Kumar Sreedharan Nair , David Smith
IPC分类号： A61F13/15 , A61L31/06 , C08G77/392 , C08L83/08 , A61F5/00 , A61Q19/00 , A61K8/895 , A61K8/02 , A61L31/10 , A61L31/14 , A61F13/20 , C08G77/12
CPC分类号： A61L31/06 , A61F5/00 , A61F13/2002 , A61K8/0208 , A61K8/895 , A61K2800/10 , A61K2800/54 , A61L31/10 , A61L31/146 , A61M2205/02 , A61Q19/00 , C08G77/12 , C08G77/392 , C08L83/08
摘要： This invention relates to medical, health care and non-medical devices comprising a rubbery or elastomeric polymer material taking up more than 5% by weight of water and at most 500% by weight of water after immersion in demineralized water at room temperature for a sufficient time to reach saturation. The material may be in the form of a foam, or in the form of a coating adapted for adhesion to a substrate, or in the form of a sheet, or in the form of a fiber, and may comprise: —repeating units from one or more hydrophobic organic monomers, and —repeating units from one or more monomers (a) being modified with one or more hydrophilic side groups.
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