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    HUMAN EMULATED RESPONSE WITH MICROFLUIDIC ENHANCED SYSTEMS
    3.
    发明申请
    HUMAN EMULATED RESPONSE WITH MICROFLUIDIC ENHANCED SYSTEMS 审中-公开
    人类对微流感增强系统的反应

    公开(公告)号：US20140308688A1

    公开(公告)日：2014-10-16

    申请号：US14362942

    申请日：2012-12-07

    Applicant: Research Triangle Institute

    Inventor： Sonia Grego ,  Brian Rhys Stoner ,  Kristin Hedgepath Gilchrist ,  Timothy Raymond Fennell ,  Ann Pitruzzello

    IPC: G01N33/50

    CPC classification number: G01N33/5014 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/028 ,  B01L2300/0645 ,  B01L2400/0481 ,  B01L2400/0487 ,  C12M21/08 ,  C12M23/16 ,  C12M23/44 ,  C12M35/08 ,  G01N33/5082

    Abstract: A multiple flow-based microfluidic cell culture system that emulates mammalian physiology is provided. Tissue-mimicking cell cultures are connected by flow within a physiologically meaningful arrangement so that the pharmacokinetics of various agents to be tested in the system emulate in vivo conditions. The system includes at least two organ tissue modules, each organ tissue module including a first chamber containing an organ tissue cell, the first chamber including an inlet and an outlet for flow of an organ tissue cell-specific culture medium; a second chamber including an inlet and an outlet for flow of a blood material; and a semi-permeable membrane separating the first and second chambers. The flow of blood material through each organ tissue module is interconnected and the flow of tissue-cell specific culture medium is directed to a single organ tissue module.

    Abstract translation: 提供了一种模拟哺乳动物生理学的基于多流的微流体细胞培养系统。 组织模拟细胞培养物在生理上有意义的排列下通过流动连接，使得在系统中待测试的各种试剂的药代动力学模拟体内条件。 所述系统包括至少两个器官组织模块，每个器官组织模块包括含有器官组织细胞的第一腔室，所述第一腔室包括用于器官组织细胞特异性培养基流动的入口和出口; 第二室，包括用于血液材料流动的入口和出口; 以及分离第一和第二室的半透膜。 通过每个器官组织模块的血液材料的流动相互连接，并且组织细胞特异性培养基的流动被引导到单个器官组织模块。

    METHOD FOR FORMING AN ULTRASOUND DEVICE, AND ASSOCIATED APPARATUS
    4.
    发明申请
    METHOD FOR FORMING AN ULTRASOUND DEVICE, AND ASSOCIATED APPARATUS 审中-公开
    形成超声波装置的方法及相关装置

    公开(公告)号：US20130261467A1

    公开(公告)日：2013-10-03

    申请号：US13906700

    申请日：2013-05-31

    Applicant: RESEARCH TRIANGLE INSTITUTE

    Inventor： David Dausch ,  James Carlson ,  Kristin Hedgepath Gilchrist

    IPC: A61B8/00 ,  A61B8/12

    CPC classification number: A61B8/4494 ,  A61B8/12 ,  A61B8/445 ,  A61N7/00 ,  B06B1/0622 ,  Y10T29/42

    Abstract: A method and apparatus directed to formation of a connection with an ultrasonic transducer apparatus (UTA) comprising a transducer device having first and second electrodes is provided. The UTA is engaged with an interposer device surface. The interposer device is greater in at least one lateral dimension than and extends laterally outward of the UTA, and comprises at least two laterally-extending conductors. A conductive engagement is formed between the first and second electrodes and respective first ends of the conductors. A connection support substrate is engaged with the interposer device about second ends of the conductors, and includes at least two connective elements for forming a conductive engagement with the respective second ends of the conductors. The UTA is then inserted into a catheter member lumen such that the device plane of the UTA and the at least two connective elements extend axially along the lumen.

    Abstract translation: 提供了一种涉及与包括具有第一和第二电极的换能器装置的超声波换能器装置（UTA）形成连接的方法和装置。 UTA与插入器器件表面接合。 所述插入器装置在至少一个横向尺寸上比UTA更大，并且横向向外延伸，并且包括至少两个横向延伸的导体。 在第一和第二电极与导体的相应的第一端之间形成导电接合。 连接支撑衬底围绕导体的第二端与插入器装置接合，并且包括用于与导体的相应第二端形成导电接合的至少两个连接元件。 然后将UTA插入导管部件内腔，使得UTA的装置平面和至少两个连接元件沿着内腔轴向延伸。

    HUMAN CONDUCTING AIRWAY MODEL COMPRISING MULTIPLE FLUIDIC PATHWAYS
    5.
    发明申请
    HUMAN CONDUCTING AIRWAY MODEL COMPRISING MULTIPLE FLUIDIC PATHWAYS 审中-公开
    包含多个流体路径的人造航空模型

    公开(公告)号：US20140335496A1

    公开(公告)日：2014-11-13

    申请号：US14362419

    申请日：2012-12-04

    Applicant: Research Triangle Institute ,  The University of North Carolina at Chapel Hill

    Inventor： Sonia Grego ,  Kristin Hedgepath Gilchrist ,  Scott H. Randell

    IPC: G09B23/30

    CPC classification number: G09B23/306 ,  C12M21/08 ,  C12M23/16 ,  C12M25/02 ,  C12M25/14 ,  C12M35/08 ,  G01N33/5088

    Abstract: A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers. A method of analyzing tissue response to an agent via an airway tissue model system is also provided.

    Abstract translation: 提供了导航气道的多细胞流体强化气道模型系统作为评估生物威胁和医疗对策的工具。 气道模型系统可以包括具有入口和出口并包含上皮细胞的第一腔室; 具有入口和出口并且包含细胞外基质的第二腔室，其中所述第二腔室通过多孔膜与所述第一腔室分离; 以及具有入口和出口的第三腔室，其中所述第三腔室通过多孔膜与所述第二腔室分离，并且其中所述气道组织模型系统构造成提供通过所述第一，第二和第 第三室。 还提供了一种通过气道组织模型系统分析对试剂的组织反应的方法。

    ULTRASOUND DEVICE, AND ASSOCIATED CABLE ASSEMBLY
    6.
    发明申请
    ULTRASOUND DEVICE, AND ASSOCIATED CABLE ASSEMBLY 审中-公开
    超声波设备和相关电缆组件

    公开(公告)号：US20130267853A1

    公开(公告)日：2013-10-10

    申请号：US13907010

    申请日：2013-05-31

    Applicant: RESEARCH TRIANGLE INSTITUTE

    Inventor： David Dausch ,  James Carlson ,  Kristin Hedgepath Gilchrist ,  Stephen Hall

    IPC: A61B8/00

    CPC classification number: A61B8/4494 ,  A61B1/0008 ,  A61B8/445 ,  A61B8/4488 ,  B06B1/0607 ,  H01L41/0475

    Abstract: An ultrasound device including an ultrasonic transducer device having a plurality of transducer elements forming a transducer array is provided. Each transducer element includes a piezoelectric material disposed between a first electrode and a second electrode. One of the first and second electrodes is a ground electrode and the other of the first and second electrodes is a signal electrode. The ultrasound device further includes a cable assembly having a plurality of connective signal elements and a plurality of connective ground elements extending in substantially parallel relation therealong. Each connective element is configured to form an electrically-conductive engagement with respective ones of the signal electrodes and the ground electrodes of the transducer elements in the transducer array. The connective ground elements are alternatingly disposed with the connective signal elements across the cable assembly, to provide shielding between the connective signal elements.

    Abstract translation: 提供了包括具有形成换能器阵列的多个换能器元件的超声波换能器装置的超声波装置。 每个换能器元件包括设置在第一电极和第二电极之间的压电材料。 第一和第二电极之一是接地电极，第一和第二电极中的另一个是信号电极。 超声波装置还包括具有多个连接信号元件的电缆组件和沿其基本上平行的关系延伸的多个连接接地元件。 每个连接元件构造成与换能器阵列中的换能器元件的信号电极和接地电极中的相应信号电极和接地电极形成导电接合。 连接接地元件与电缆组件之间的连接信号元件交替布置，以提供连接信号元件之间的屏蔽。

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