公开(公告)号：US12025613B2

公开(公告)日：2024-07-02

申请号：US17551723

申请日：2021-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Michael Gerg ,  Dieter Heindl ,  Lars Hillringhaus ,  Klaus Hirzel ,  Caroline Dorothea Hojer ,  Florian Huber ,  Hans-Peter Josel ,  Thomas Meier ,  Michael Schraeml ,  Edgar Voss

IPC: G01N33/543 ,  C07K16/44

CPC classification number: G01N33/54306 ,  C07K16/44

Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

公开(公告)号：US11885818B2

公开(公告)日：2024-01-30

申请号：US17155054

申请日：2021-01-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Hans-Peter Josel ,  Uwe Kobold ,  Christoph Seidel ,  Martin Rempt ,  Andreas Leinenbach ,  Giuseppe Prencipe ,  Silvia Baecher ,  Simon Ferdinand Loibl ,  Anna-Skrollan Geiermann ,  Jelena Milic ,  Nicole Pirkl

IPC: C07D401/06 ,  C07D413/06 ,  G01N33/74 ,  G01N33/58 ,  C07J43/00

CPC classification number: G01N33/743 ,  C07D401/06 ,  C07D413/06 ,  C07J43/003 ,  G01N33/58 ,  G01N2560/00

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

公开(公告)号：US11021472B2

公开(公告)日：2021-06-01

申请号：US15186580

申请日：2016-06-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Dieter Heindl ,  Thomas Froehlich ,  Stefanie Froehner

IPC: C07D409/04 ,  C12M1/42 ,  C07J51/00 ,  G01N33/543 ,  G01N33/50 ,  C12N5/00

Abstract: The present invention relates to the use compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising a polyethylene glycol (PEG) moiety for stabilization of a cell, and methods related thereto.

公开(公告)号：US20200024292A1

公开(公告)日：2020-01-23

申请号：US16284346

申请日：2019-02-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Tobias Oelschlaegel ,  Giuseppe Prencipe ,  Luisa De Cola ,  Elena Longhi ,  Chien-Wei Hsu

IPC: C07F7/08 ,  C09K11/06

Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.

公开(公告)号：US20190388402A1

公开(公告)日：2019-12-26

申请号：US16562629

申请日：2019-09-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ewelina Hegel ,  Hans-Peter Josel ,  Eloisa Lopez-Calle ,  Josef Roedl ,  Noah Weiss ,  Benjamin Tiemann

IPC: A61K31/436 ,  A61K47/18 ,  A61K9/08

Abstract: The present description relates to a liquid composition having at least one immune-modulatory macrolide compound and an essentially cell-free blood hemolysate. The present description further relates to a method for manufacturing a stabilized immune-modulatory macrolide calibration solution, by a) preparing a solution comprising an essentially cell-free blood hemolysate, b) admixing a predetermined amount of at least one immune-modulatory macrolide into said solution comprising an essentially cell-free blood hemolysate, and, thereby c) manufacturing a stabilized immune-modulatory macrolide calibration solution. Furthermore, the present description relates to kits, uses, devices, methods and to an immune-modulatory macrolide compound calibration solution related thereto.

公开(公告)号：US09499573B2

公开(公告)日：2016-11-22

申请号：US14610244

申请日：2015-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Robert Cysewski ,  Luisa de Cola ,  Sebastian Dziadek ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Elena Longhi ,  Christoph Seidel

IPC: C07F15/00 ,  G01N33/58 ,  C09K11/06

CPC classification number: C07F15/0033 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1059 ,  C09K2211/14 ,  C09K2211/1416 ,  C09K2211/1425 ,  C09K2211/1441 ,  C09K2211/1466 ,  C09K2211/1475 ,  C09K2211/1491 ,  C09K2211/185 ,  G01N33/582 ,  G01N2458/30

Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

公开(公告)号：US20150147752A1

公开(公告)日：2015-05-28

申请号：US14610244

申请日：2015-01-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Robert Cysewski ,  Luisa de Cola ,  Sebastian Dziadek ,  Jesus Miguel Fernandez Hernandez ,  Hans-Peter Josel ,  Elena Longhi ,  Christoph Seidel

IPC: C07F15/00 ,  G01N33/58

CPC classification number: C07F15/0033 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/1059 ,  C09K2211/14 ,  C09K2211/1416 ,  C09K2211/1425 ,  C09K2211/1441 ,  C09K2211/1466 ,  C09K2211/1475 ,  C09K2211/1491 ,  C09K2211/185 ,  G01N33/582 ,  G01N2458/30

Abstract: The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.

公开(公告)号：US20240092742A1

公开(公告)日：2024-03-21

申请号：US18500149

申请日：2023-11-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Hans-Peter Josel ,  Uwe Kobold ,  Christoph Seidel ,  Martin Rempt ,  Andreas Leinenbach ,  Giuseppe Prencipe ,  Silvia Baecher ,  Simon Ferdinand Loibl ,  Anna-Skrollan Geiermann ,  Jelena Milic ,  Nicole Pirkl

IPC: C07D249/06 ,  C07D203/04 ,  C07D249/04 ,  C07D257/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D471/04

CPC classification number: C07D249/06 ,  C07D203/04 ,  C07D249/04 ,  C07D257/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D471/04 ,  G01N30/72

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

公开(公告)号：US20210188788A1

公开(公告)日：2021-06-24

申请号：US17154501

申请日：2021-01-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Hans-Peter Josel ,  Uwe Kobold ,  Christoph Seidel ,  Martin Rempt ,  Andreas Leinenbach ,  Giuseppe Prencipe ,  Silvia Baecher ,  Simon Ferdinand Loibl ,  Anna-Skrollan Geiermann ,  Jelena Milic ,  Robert Hahn ,  Nicole Pirkl

IPC: C07D257/04 ,  C07D249/06 ,  H01J49/00

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

公开(公告)号：US20210102944A1

公开(公告)日：2021-04-08

申请号：US17115069

申请日：2020-12-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Dieter Heindl ,  Thomas Froehlich ,  Stefanie Froehner

IPC: G01N33/569 ,  C12N11/06 ,  G01N33/50 ,  G01N33/543 ,  C12N5/00 ,  C12N11/14 ,  C12N11/08

Abstract: The present invention relates to a method of immobilizing a cell on a support, the method comprising a) providing a compound or salt thereof comprising, preferably consisting of, one or more hydrophobic domains attached to a hydrophilic domain, wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain, and wherein the one or more hydrophobic domains each comprise a linear lipid, a steroid or a hydrophobic vitamin, and wherein the hydrophilic domain comprises a polyethylene glycol (PEG) moiety, and wherein the compound comprises a linking group; b) contacting a cell with the compound under conditions allowing the interaction of the compound with the membrane of the cell, thereby immobilizing the linking group on the surface of the cell; and c) contacting the linking group immobilized on the cell with a support capable of binding the linking group, thereby immobilizing the cell on the support.