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    Beta-carbolines as growth hormone secretagogue receptor (GHSR) antagonists
    1.
    发明申请
    Beta-carbolines as growth hormone secretagogue receptor (GHSR) antagonists 审中-公开
    β-咔啉作为生长激素促分泌素受体（GHSR）拮抗剂

    公开(公告)号：US20050288316A1

    公开(公告)日：2005-12-29

    申请号：US10995067

    申请日：2004-11-22

    申请人： Roger Crossley ,  Annika Jensen ,  Peter Brandt ,  Ulf Bremberg ,  Malin Nordberg ,  Erik Ringberg ,  Terry Ward

    发明人： Roger Crossley ,  Annika Jensen ,  Peter Brandt ,  Ulf Bremberg ,  Malin Nordberg ,  Erik Ringberg ,  Terry Ward

    IPC分类号： A61K20060101 ,  A61K31/407 ,  A61K31/4747 ,  C07D471/20 ,  C07D491/14 ,  C07D491/20

    CPC分类号： C07D471/20 ,  C07D491/20

    摘要： The present invention relates to compounds of Formula (I): wherein R3-R8, X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 3，R 8，X和Y如本文所述，制备化合物的方法，药物组合物 包括化合物，以及化合物和组合物在预防或治疗GHSR受体相关病症中的用途。 这种障碍的例子是肥胖症和相关疾病，例如II型糖尿病，血脂异常和代谢综合征Prader-Willi综合征，心血管疾病如动脉粥样硬化性血管疾病，心绞痛，心肌梗塞和中风，肢端肥大症和癌症，特别是乳腺，肺 ，前列腺，甲状腺和内分泌胰腺癌。

    New compounds
    6.
    发明申请
    New compounds 审中-公开
    新化合物

    公开(公告)号：US20060217375A1

    公开(公告)日：2006-09-28

    申请号：US11318126

    申请日：2005-12-22

    申请人： Emma Barker ,  Annika Jensen ,  Erik Nordling ,  Andrew Proud ,  Martin Slater ,  Michael Weber ,  Lars Tedenborg

    发明人： Emma Barker ,  Annika Jensen ,  Erik Nordling ,  Andrew Proud ,  Martin Slater ,  Michael Weber ,  Lars Tedenborg

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  C07D491/10

    CPC分类号： C07D491/10 ,  C07D493/10

    摘要： The present invention relates to compounds of Formula (I): wherein R1, A, Y, n and m are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of orexin-1 receptor-related disorders and orexin-2 receptor-related disorders. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, drug addiction, and sleeping disorders.

    摘要翻译： 本发明涉及式（I）的化合物：其中R 1，A，Y，n和m如本文所述，制备化合物的方法，包含该化合物的药物组合物和使用 预防或治疗食欲肽-1受体相关疾病和食欲肽-2受体相关疾病的化合物和组合物。 这种障碍的实例是肥胖症和相关疾病，例如II型糖尿病，血脂异常和代谢综合征，心血管疾病如动脉粥样硬化性血管疾病，心绞痛，心肌梗死和中风，药物成瘾和睡眠障碍。