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公开(公告)号：US20230026108A1
公开(公告)日：2023-01-26
申请号：US17783839
申请日：2020-12-10
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Amir ZAIT , Dan GLUCK , Arnon HOURI YAFIN , David BRAILOVSKY , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.
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公开(公告)号：US20250067968A1
公开(公告)日：2025-02-27
申请号：US18940926
申请日：2024-11-08
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample and a display, including acquiring a plurality of images of a microscopic imaging field of the blood sample, each of the images being acquired using respective, different imaging conditions. An artificial color microscopic display image of the microscopic imaging field is generated having a similar appearance to that of a color smear image, by mapping the plurality of images to respective channels of the artificial color microscopic display image. A display is driven to display the artificial color microscopic display image of the microscopic imaging field to a user. Other applications are also described.
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公开(公告)号：US20210041422A1
公开(公告)日：2021-02-11
申请号：US17082615
申请日：2020-10-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N15/06 , G01N33/569
Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.
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公开(公告)号：US20220019070A1
公开(公告)日：2022-01-20
申请号：US17490767
申请日：2021-09-30
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for analyzing a bodily sample. One or more microscope images of the bodily sample are acquired. Using at least one computer processor at least one sample-informative feature that is indicative of a characteristic of the bodily sample is extracted from the images. Based upon the sample-informative feature, the computer processor determines that there is a defect associated with the bodily sample, and determines a source of the defect. Other applications are also described.
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公开(公告)号：US20200249459A1
公开(公告)日：2020-08-06
申请号：US16851686
申请日：2020-04-17
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods are described including staining a blood sample with one or more stains. A plurality of microscopic images of the stained blood sample are acquired, using a microscope. Staining-quality parameters for respective microscopic images are determined, using a computer processor, the staining-quality parameters being indicative of a quality of the staining within each of the respective microscopic images. An action is performed by the computer processor, based upon the staining-quality parameters of the respective microscopic images. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20230028360A1
公开(公告)日：2023-01-26
申请号：US17783924
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample. Using a microscope (24), three images of a microscopic imaging field of the blood sample are acquired, each of the images being acquired using respective, different imaging conditions, and the first one of the three images being acquired under violet-light brightfield imaging. Using at least one computer processor (28), an artificial color microscopic image of the microscopic imaging field is generated, by mapping the first one of the three images to a red channel of the artificial color microscopic image, mapping a second one of the three images to a second color channel of the artificial color microscopic image, and mapping a third one of the three images to a third color channel of the artificial color microscopic image. Other applications are also described.
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公开(公告)号：US20230011382A1
公开(公告)日：2023-01-12
申请号：US17783831
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Dan GLUCK , Amir ZAIT , Arnon HOURI YAFIN , Yonatan HALPERIN , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK , Sharon PECKER , Peretz YAFIN , Dana BENBASSAT , David BRAILOVSKY , Uriyah PUMERANTZ
Abstract: Apparatus and methods are described use with a bodily sample that contains cells. A microscope (24) is focused, such that a focal plane of the microscope (24) at least approximately coincides with a level at which at least some cells belonging to the sample are at least partially disposed. At least one on-focus microscopic image of the sample, while the focal plane of the microscope (24) approximately coincides with the level. The microscope (24) is focused such that the focal plane of the microscope is offset with respect to the level, at least one off-focus microscopic image of the sample is acquired, while the focal plane of the microscope (24) is offset with respect to the level. A property of at least a portion of the sample is determined, at least partially based upon the on-focus and off-focus images. Other applications are also described.
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公开(公告)号：US20230003622A1
公开(公告)日：2023-01-05
申请号：US17783930
申请日：2020-12-10
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Peretz YAFIN , Dan GLUCK , Amir ZAIT , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are provided including imaging a blood sample that is a cell suspension deposited in a sample chamber. The cells are allowed to settle in the sample chamber to form a monolayer of cells. At least one microscopic image is acquired of the monolayer of cells using a microscope (24) while the microscope is focused at a monolayer-depth-level, and a first platelet count of platelets that have settled within the monolayer, is determined. An additional microscopic image of the simple is acquired, while the microscope is focused at a different depth level from the monolayer-depth-level, and a second platelet count of platelets that have not settled within the monolayer is determined. An output is generated based upon the first and second platelet counts. Other applications are also described.
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公开(公告)号：US20220390372A1
公开(公告)日：2022-12-08
申请号：US17770339
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20200049970A1
公开(公告)日：2020-02-13
申请号：US16657473
申请日：2019-10-18
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods for analyzing a bodily sample are described. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies, in the one or more images, at least one element as being a candidate of a given entity. The computer processor extracts, from the one or more images, at least one candidate-informative feature associated with the candidate of the given entity, and at least one sample-informative feature that is indicative of a characteristic of the bodily sample as a whole. The computer processor processes the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.
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