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公开(公告)号：US12005443B2
公开(公告)日：2024-06-11
申请号：US17064193
申请日：2020-10-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Ido Bachelet , Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Noam Yorav-Raphael
CPC classification number: B01L3/502715 , G01N15/1433 , G01N21/23 , G01N21/5907 , G01N21/6458 , B01L2300/0816 , B01L2300/0864 , G01N2015/016 , G01N2015/1006 , G01N2021/5957 , G01N2021/6419 , G01N2021/6421 , G06V2201/03 , G06V2201/04
Abstract: Apparatus and methods are described including successively acquiring a plurality of microscopic images of a portion of a blood sample, and tracking motion of pixels within the successively acquired microscopic images. Trypomastigote parasite candidates within the blood sample are identified, by identifying pixel motion that is typical of trypomastigote parasites. It is determined that the blood sample is infected with trypomastigote parasites, at least partially in response thereto. An output is generated indicating that that the blood sample is infected with trypomastigote parasites. Other applications are also described.
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公开(公告)号：US11584950B2
公开(公告)日：2023-02-21
申请号：US16705941
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Arnon Houri Yafin , Noam Yorav-Raphael , Yuval Greenfield
Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.
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公开(公告)号：US10831013B2
公开(公告)日：2020-11-10
申请号：US14914329
申请日：2014-08-26
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam Yorav Raphael , Yuval Greenfield , Joseph Joel Pollak , Yonatan Bilu
Abstract: Methods, systems and computer program products relating to digital microscopy are disclosed. A digital microscopy method may comprise capturing a plurality of overlapping images of a sample, wherein the capturing of at least one of the plurality of images is performed while the sample and a focal plane are in relative motion along an optical axis at a speed greater than zero; and processing the plurality of images using a reference criterion to determine a reference relative arrangement of the focal plane and the sample along the optical axis.
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公开(公告)号：US20160279633A1
公开(公告)日：2016-09-29
申请号：US15174490
申请日：2016-06-06
Applicant: S.D. Sight Diagnostics Ltd
Inventor： Ido Bachelet , Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a digital camera that is configured to acquire images of a bodily sample. Two or more stains are configured to stain the bodily sample. A computer processor drives the digital camera to acquire, for each of a plurality of imaging fields of the bodily sample, two or more digital images, at least one of the images being acquired under brightfield lighting conditions, and at least one of the images being acquired under fluorescent lighting conditions. The computer processor performs image processing on the digital images, by extracting visual classification features from the digital images and analyzing the extracted visual classification features. The computer processor outputs a result of the image processing that includes an indication of one or more entities that are contained within the sample. Other applications are also described.
Abstract translation: 描述了与被配置为获取身体样本的图像的数字照相机一起使用的装置和方法。 两个或多个污渍被配置为染色身体样品。 计算机处理器驱动数字照相机以对于身体样本的多个成像场域中的每一个采集两个或更多个数字图像，在明场照明条件下获取至少一个图像，并且至少一个图像是 在荧光照明条件下获得。 计算机处理器通过从数字图像提取视觉分类特征并分析提取的视觉分类特征，对数字图像执行图像处理。 计算机处理器输出包括样本中包含的一个或多个实体的指示的图像处理的结果。 还描述了其它应用。
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公开(公告)号：US11295440B2
公开(公告)日：2022-04-05
申请号：US16706159
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a sample that includes a plurality of red blood cells. A series of images associated with a series of depth levels of the sample are acquired, by performing a depth scan of the sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level. The sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20200181680A1
公开(公告)日：2020-06-11
申请号：US16705941
申请日：2019-12-06
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Joseph Joel Pollak , Daniel Levner , Yonatan Bilu , Arnon Houri Yafin , Noam Yorav-Raphael , Yuval Greenfield
Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with Hoechst stain and Acridine Orange stain. A plurality of images of the blood sample are acquired. An object is identified as being a white blood cell candidate. A first stained area, which is stained by the Hoechst stain and which is disposed within the white blood cell candidate, is identified. A second stained area, which is stained by the Acridine Orange stain and which is disposed within the white blood cell candidate, is identified. A white blood cell is detected by determining that structural features of the stained areas satisfy predetermined criteria associated with a white blood cell. Other applications are also described.
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公开(公告)号：US20190130567A1
公开(公告)日：2019-05-02
申请号：US16232124
申请日：2018-12-26
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.
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公开(公告)号：US11803964B2
公开(公告)日：2023-10-31
申请号：US17576023
申请日：2022-01-14
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
CPC classification number: G06T7/0012 , G02B7/38 , G02B21/16 , G02B21/244 , G02B21/361 , G02B21/367 , G06T7/507 , G06T2207/10056 , G06T2207/30024
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells disposed in a monolayer. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, by identifying that a drop in image contrast occurs at the identified depth level relative to the image contrast of images acquired at depth levels within a given range of distances from the identified depth level. The cell sample is imaged using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US11100634B2
公开(公告)日：2021-08-24
申请号：US16232124
申请日：2018-12-26
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.
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公开(公告)号：US10176565B2
公开(公告)日：2019-01-08
申请号：US14285672
申请日：2014-05-23
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Yuval Greenfield , Yonatan Bilu , Joseph Joel Pollak , Noam Yorav-Raphael
Abstract: The present disclosure provides a method of determining a reference depth level within a cell sample. The method comprises obtaining data representative of a series of images captured by performing a depth scan of the cell sample using a digital microscope, the series of images being associated with a series of depth levels of the cell sample; processing said data for detecting at least one depth level corresponding to a drop in image contrast; and identifying the detected depth level as the reference depth level.
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