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公开(公告)号：US5210239A
公开(公告)日：1993-05-11
申请号：US576054
申请日：1990-08-31
申请人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
发明人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
IPC分类号： A61K31/16 , A61K31/00 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/16 , C07C45/00 , C07C47/575 , C07C50/38 , C07C51/09 , C07C59/54 , C07C59/58 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/82 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/16 , C07C69/734 , C07C69/738 , C07C235/30 , C07C235/78 , C07C255/31 , C07C255/41 , C07C255/53 , C07C255/57 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/60 , C07C323/62 , C07D211/46 , C07D213/55 , C07D265/30 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/46 , C07D295/18 , C07D295/185 , C07D309/04 , C07D309/06 , C07D333/24 , C07D521/00
CPC分类号： C07D295/185 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24 , C07C2101/14 , C07C2101/16
摘要： A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.
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公开(公告)号：US5385942A
公开(公告)日：1995-01-31
申请号：US22688
申请日：1993-03-01
申请人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
发明人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
IPC分类号： A61K31/16 , A61K31/00 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/16 , C07C45/00 , C07C47/575 , C07C50/38 , C07C51/09 , C07C59/54 , C07C59/58 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/82 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/16 , C07C69/734 , C07C69/738 , C07C235/30 , C07C235/78 , C07C255/31 , C07C255/41 , C07C255/53 , C07C255/57 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/60 , C07C323/62 , C07D211/46 , C07D213/55 , C07D265/30 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/46 , C07D295/18 , C07D295/185 , C07D309/04 , C07D309/06 , C07D333/24 , C07D521/00
CPC分类号： C07D295/185 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24 , C07C2101/14 , C07C2101/16
摘要： A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.
摘要翻译： 用于治疗由以下通式定义的肝脏疾病的醌衍生物：其中X和Y可以相同或不同，并且各自为羟基，由式表示的基团 - （ - OCH 2 - ）n-OR 6，其中n为0或1，R6为低级烷基或酰基。
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公开(公告)号：US5292901A
公开(公告)日：1994-03-08
申请号：US832220
申请日：1992-02-06
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译： 新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基，其是羧烷基硫代烷基等，并且有效治疗肝脏疾病。
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公开(公告)号：US5110956A
公开(公告)日：1992-05-05
申请号：US517444
申请日：1990-04-23
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： A61K31/335 , C07D317/46 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04
CPC分类号： C07D405/12 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D413/12 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译： 提供苯并间二氧杂环戊烯衍生物在苯环中具有取代基，羧基烷基硫代烷基等。 这样的衍生物有效治疗肝脏疾病。 还提供了包含这些衍生物的组合物以及这些衍生物用于制备药物的用途。
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公开(公告)号：US5475024A
公开(公告)日：1995-12-12
申请号：US166019
申请日：1993-10-14
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译： 新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基，其是羧烷基硫代烷基等，并且有效治疗肝脏疾病。
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公开(公告)号：US5075335A
公开(公告)日：1991-12-24
申请号：US495444
申请日：1990-03-16
申请人： Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
发明人： Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
IPC分类号： A61K31/235 , A61K31/245 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/445 , A61P1/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/20 , C07D207/40 , C07D207/404 , C07D207/408 , C07D209/48 , C07D209/76 , C07D211/76 , C07D211/88 , C07D263/44
CPC分类号： C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要： A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
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公开(公告)号：US4801603A
公开(公告)日：1989-01-31
申请号：US946458
申请日：1986-12-24
申请人： Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
发明人： Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
IPC分类号： A61K31/235 , A61K31/245 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/445 , A61P1/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/20 , C07D207/40 , C07D207/404 , C07D207/408 , C07D209/48 , C07D209/76 , C07D211/76 , C07D211/88 , C07D263/44
CPC分类号： C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要： A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m --, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
摘要翻译： 具有下式的胍基苯甲酸酯衍生物是新颖有效的抑制酶如胰蛋白酶，纤溶酶和凝血酶，可用于治疗胰腺炎和出血性疾病和血栓形成。 其中X表示下式的基团：其中Y是下式的基团： - （CH 2）m - ，m是2或3的整数，
或基团 其中R是氢原子或低级烷基，n表示1〜5的整数。 -
公开(公告)号：US4948808A
公开(公告)日：1990-08-14
申请号：US225278
申请日：1988-07-28
申请人： Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
发明人： Shigeru Souda , Naoyuki Shimomura , Norihiro Ueda , Shuhei Miyazawa , Takashi Yamanaka , Kaname Miyamoto , Ieharu Hishinuma , Junichi Nagakawa , Naoko Nagaoka , Hidetoshi Kawashima , Tsutomu Kawata , Junsaku Nagaoka , Tsuneo Wakabayashi
IPC分类号： A61K31/235 , A61K31/245 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/445 , A61P1/00 , A61P7/02 , A61P7/04 , A61P43/00 , C07C67/00 , C07C313/00 , C07C319/20 , C07C323/20 , C07D207/40 , C07D207/404 , C07D207/408 , C07D209/48 , C07D209/76 , C07D211/76 , C07D211/88 , C07D263/44
CPC分类号： C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要： A guanidinobenzoic ester derivative having the formula is novel and effective to inhibit enzymes such as trypsin, plasmin and thrombin, being useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis. ##STR1## wherein X represents a group of the formula: ##STR2## in which Y is a group of the formula: --(CH.sub.2).sub.m--, m being an integer of 2 or 3, ##STR3## or a group of the formula:--ORin which R is a hydrogen atom or a lower alkyl group, and n represents an integer of 1 to 5.
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公开(公告)号：US5329010A
公开(公告)日：1994-07-12
申请号：US840862
申请日：1992-02-25
申请人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Tetsuya Kawahara , Naoki Kobayashi , Masanobu Shinoda , Koukichi Harada , Kaname Miyamoto , Koichi Abe
发明人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Tetsuya Kawahara , Naoki Kobayashi , Masanobu Shinoda , Koukichi Harada , Kaname Miyamoto , Koichi Abe
IPC分类号： A61K31/44 , A61K31/122 , A61K31/4164 , A61K31/4406 , A61K31/4418 , A61K31/5377 , A61P1/16 , A61P11/06 , A61P11/08 , A61P43/00 , C07C50/06 , C07D213/28 , C07D213/50 , C07D213/55 , C07D213/56 , C07D233/54 , C07D233/64
CPC分类号： C07D213/56 , C07D213/55
摘要： The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy groupR.sup.1 stands for a heteroarylalkyl group; andB stands for a carboxyl group or a protected carboxyl group.
摘要翻译： 本发明是由通式（I）表示的优异的治疗活性或其药理学上可接受的盐的醌衍生物：其中A表示由下式表示的基团：（其中R 3 R 4和R 5彼此相同或不同，分别表示氢原子，羟基，低级烷基，低级烷氧基，烷氧基烷基，烷氧基烷氧基，环烷基烷氧基，硫醇基或 硫烷基，条件是R 3和R 4各自为低级烷氧基，R 1表示杂芳基烷基; B表示羧基或被保护的羧基。
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