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    Antibodies to natural killer cell activating factor II
    9.
    发明授权
    Antibodies to natural killer cell activating factor II 失效
    自然杀伤细胞激活因子II的抗体

    公开(公告)号：US07309780B2

    公开(公告)日：2007-12-18

    申请号：US11378243

    申请日：2006-03-20

    申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/06 ,  C12N5/16

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/52

    摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Chemokine alpha 2
    10.
    发明授权
    Chemokine alpha 2 失效
    趋化因子α2

    公开(公告)号：US06479633B1

    公开(公告)日：2002-11-12

    申请号：US09238184

    申请日：1999-01-27

    申请人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

    发明人： Jian Ni ,  Reiner L. Gentz ,  Jeffrey Y. Su ,  Haodong Li

    IPC分类号： C07K100

    CPC分类号： C07K14/522 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026

    摘要： Human chemokine Alpha-2 polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.

    摘要翻译： 公开了人趋化因子α-2多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。