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公开(公告)号：US20210363130A1
公开(公告)日：2021-11-25
申请号：US17042394
申请日：2019-03-28
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Koji ONO , Masahiro ITO , Toshio TANAKA , Moriteru ASANO , Takaharu HIRAYAMA , Jun FUJIMOTO , Nobuki SAKAUCHI , Yasuhiro HIRATA , Akinori TOITA , Nao MORISHITA , Hironori KOKUBO , Yasuhiro IMAEDA , Hironobu MAEZAKI , Douglas Robert CARY , Ryo MIZOJIRI , Nobuo CHO , Hiroshi BANNO , Hidekazu TOKUHARA , Yasuyoshi ARIKAWA
IPC: C07D401/14 , A61P35/00 , C07D401/12 , C07D405/14 , C07D405/12 , C07D213/84 , C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , C07D495/10
Abstract: Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20190241566A1
公开(公告)日：2019-08-08
申请号：US16333296
申请日：2017-09-14
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Takaharu HIRAYAMA , Yasuhiro HIRATA , Yusuke TOMINARI , Naoki IWAMURA , Yusuke SASAKI , Moriteru ASANO , Terufumi TAKAGI , Masanori OKANIWA , Masato YOSHIDA , Takashi ICHIKAWA , Shinichi IMAMURA
IPC: C07D473/28 , C07D473/40 , C07D519/00 , C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D409/14 , C07D405/14 , C07D401/04 , A61P35/00
Abstract: Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein a group represented by is a group represented by the following formula (II) or the following formula (III): and other symbols are as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20200377509A1
公开(公告)日：2020-12-03
申请号：US16497141
申请日：2018-03-29
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED , SCOHIA PHARMA, INC
Inventor： Seiji MIWATASHI , Yasufumi MIYAMOTO , Koji WATANABE , Yayoi NAKAYAMA , Yuko HITOMI , Jumpei AIDA , Nobuyuki TAKAKURA , Hideki FURUKAWA , Naoyoshi NOGUCHI , Yasuhiro HIRATA , Shizuo KASAl , Toshitake KOBAYASHI , Tsuyoshi MAEKAWA , Satoshi SASAKI , Shigemitsu MATSUMOTO
IPC: C07D491/052 , C07D401/12 , C07D401/14 , C07D211/22
Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US20170044132A1
公开(公告)日：2017-02-16
申请号：US15304623
申请日：2015-04-16
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Takaharu HIRAYAMA , Jun FUJIMOTO , Douglas Robert CARY , Masanori OKANIWA , Yasuhiro HIRATA
IPC: C07D401/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D401/14 , C07D487/08 , C07D491/08 , C07D405/14 , C07D487/04 , C07D491/107 , C07D417/04 , C07D409/14 , C07D498/08
CPC classification number: C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4704 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/499 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/553 , C07D213/64 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula (I) (in the formula, the symbols are as defined in the description) or a salt thereof.
Abstract translation: （在该式中，符号如说明书中所定义）或其盐。
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公开(公告)号：US20230117295A1
公开(公告)日：2023-04-20
申请号：US18075853
申请日：2022-12-06
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Koji ONO , Masahiro ITO , Toshio TANAKA , Moriteru ASANO , Takaharu HIRAYAMA , Jun FUJIMOTO , Nobuki SAKAUCHI , Yasuhiro HIRATA , Akinori TOITA , Nao MORISHITA , Hironori KOKUBO , Yasuhiro IMAEDA , Hironobu MAEZAKI , Douglas Robert CARY , Ryo MIZOJIRI , Nobuo CHO , Hiroshi BANNO , Hidekazu TOKUHARA , Yasuyoshi ARIKAWA
IPC: C07D401/14 , C07D403/14 , C07D401/12 , C07D471/10 , C07D495/10 , C07D405/12 , C07D403/12 , C07D213/84 , C07D487/10 , C07D405/14 , A61P35/00
Abstract: Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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Patent Agency Ranking
公开(公告)号：US20180170874A1
公开(公告)日：2018-06-21
申请号：US15565891
申请日：2016-04-19
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Yasutomi ASANO , Takuto KOJIMA , Osamu KURASAWA , Tzu-Tshin WONG , Yasuhiro HIRATA , Naoki IWAMURA , Bunnai SAITO , Yuta TANAKA , Ryosuke ARAI , Shinichi IMAMURA , Kazuko YONEMORI , Yasufumi MIYAMOTO , Shuji KITAMURA , Osamu SANO
IPC: C07D211/58 , C07D471/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07D215/42 , C07D401/12 , C07D417/12 , C07D405/06 , C07D413/06 , C07D401/06 , C07D417/06 , C07D401/14 , C07D417/14 , C07D413/14 , C07B59/00 , A61P35/00 , A61P3/00
CPC classification number: C07D211/58 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , A61P3/00 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D215/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , C07F9/6509
Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US20200039957A1
公开(公告)日：2020-02-06
申请号：US16499432
申请日：2018-03-29
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Seiji MIWATASHI , Yasufumi MIYAMOTO , Koji WATANABE , Yayoi NAKAYAMA , Yuko HITOMI , Jumpei AIDA , Nobuyuki TAKAKURA , Hideki FURUKAWA , Naoyoshi NOGUCHI , Yasuhiro HIRATA , Kazuaki TAKAMI , Norihito TOKUNAGA , Tomohiro OKAWA , Akita SHIBUYA , Shizuo KASAl , Toshitake KOBAYASHI , Tsuyoshi MAEKAWA
IPC: C07D401/12 , C07D211/22 , C07D401/14 , C07C59/72 , C07D213/64 , C07D401/10 , C07D413/10
Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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公开(公告)号：US20190359587A1
公开(公告)日：2019-11-28
申请号：US16332993
申请日：2017-09-14
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Takaharu HIRAYAMA , Yasuhiro HIRATA , Yusuke TOMINARI , Naoki IWAMURA , Yusuke SASAKI , Moriteru ASANO , Terufumi TAKAGI , Masanori OKANIWA , Masato YOSHIDA , Shinichi IMAMURA
IPC: C07D401/04 , A61P35/00 , C07D409/14 , C07D401/14 , C07D417/14 , C07D407/14
Abstract: Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20190062274A1
公开(公告)日：2019-02-28
申请号：US16175144
申请日：2018-10-30
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Yasutomi ASANO , Takuto KOJIMA , Osamu KURASAWA , Tzu-Tshin WONG , Yasuhiro HIRATA , Naoki IWAMURA , Bunnai SAITO , Yuta TANAKA , Ryosuke ARAI , Shinichi IMAMURA , Kazuko YONEMORI , Yasufumi MIYAMOTO , Shuji KITAMURA , Osamu SANO
IPC: C07D211/58 , C07F9/6509 , C07D405/06 , A61P3/00 , A61P35/00 , C07B59/00 , C07D413/14 , C07F5/02 , C07D519/00 , C07D513/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D417/14 , C07D417/12 , C07D417/06 , C07D413/06 , C07D409/12 , C07D401/12 , C07D401/06 , C07D215/42 , A61K33/22 , A61K31/661 , A61K31/5355 , A61K31/517 , A61K31/506 , A61K31/498 , A61K31/4709 , A61K31/452 , A61K31/451 , A61K31/4468 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/4433 , A61K31/443 , A61K31/437 , C07D401/14
CPC classification number: C07D211/58 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , A61P3/00 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D215/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , C07F9/6509 , Y02P20/55
Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US20160115128A1
公开(公告)日：2016-04-28
申请号：US14898633
申请日：2014-08-08
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Jumpei AIDA , Yayoi YOSHITOMI , Yuko HITOMI , Naoyoshi NOGUCHI , Yasuhiro HIRATA , Hideki FURUKAWA , Akito SHIBUYA , Koji WATANABE , Yasufumi MIYAMOTO , Tomohiro OKAWA , Nobuyuki TAKAKURA , Seiji MIWATASHI
IPC: C07D211/34 , C07D413/10 , C07D401/14 , C07D405/12 , C07D413/14 , C07D401/10 , C07D401/12
CPC classification number: C07D211/34 , C07D211/22 , C07D213/30 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/14
Abstract: Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.
Abstract translation: 提供具有GPR40激动剂活性和GLP-1促分泌作用的新型芳环化合物。 由下式表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性和GLP-1促分泌素作用，可用于预防或治疗癌症，肥胖症，糖尿病，高血压， 高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症等，具有优异的疗效。
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