Polyphosphate:AMP phosphotransferase
    4.
    发明授权
    Polyphosphate:AMP phosphotransferase 有权
    多磷酸盐:AMP磷酸转移酶

    公开(公告)号:US07329522B2

    公开(公告)日:2008-02-12

    申请号:US10514726

    申请日:2003-05-28

    摘要: This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties:(A) action: catalyzing of the following two reactions: NMP+PolyP(n)→NDP+PolyP(n-1) dNMP+POlyP(n)→dNDP+PolyP(n-1) (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP, and TMP;(C) molecular weight: about 55 to 56 Kd (kilodalton); and(D) specific activity: at least 70 units per 1 mg of enzyme protein.

    摘要翻译: 本发明涉及新型多磷酸盐:AMP磷酸转移酶(PAP),编码该PAP的基因及其用途。 PAP具有以下性质:(A)作用:催化以下两个反应:<?in-line-formula description =“In-line Formulas”end =“lead”?> NMP + PolyP(n) - > NDP + PolyP(n-1) <?in-line-formula description =“In-line Formulas”end =“tail”?> <?in-line-formula description =“In-Line Formulas”end =“lead”?> dNMP + POlyP(n) - > dNDP + PolyP(n-1) (其中NMP表示核苷单磷酸,NDP表示核苷二磷酸,dNMP表示脱氧核苷单磷酸,dNDP表示脱氧核苷二磷酸,n表示多磷酸酯的聚合度, 整数高达100); (B)底物特异性:特异于AMP,GMP,IMP,dAMP和dGMP,也与CMP,UMP,dCMP和TMP起作用; (C)分子量:约55至56Kd(千道尔顿); 和(D)比活性:每1mg酶蛋白至少70个单位。

    Oral Composition For Removing Tooth Stain
    6.
    发明申请
    Oral Composition For Removing Tooth Stain 审中-公开
    用于去除牙齿污迹的口腔成分

    公开(公告)号:US20130189200A1

    公开(公告)日:2013-07-25

    申请号:US13825555

    申请日:2011-09-22

    摘要: [Problem] The object of the present invention is to provide an oral composition, which can remove tooth stain effectively. The object of the present invention is also to provide an oral composition, which scarcely damages teeth and gums and can be easily applied.[Method of solution] An oral composition for removing tooth stain, which comprises 3.5 to 30% by weight of peroxide and 5 to 20% by weight of phosphate polymer (in particular, ultraphosphate having an average chain length of phosphoric acid polymerization of 10 to 30).

    摘要翻译: 本发明的目的在于提供能有效去除牙齿污渍的口腔用组合物。 本发明的目的还在于提供一种几乎不损伤牙齿和牙龈并且可以容易地应用的口腔用组合物。 [溶液的方法]一种用于除去牙齿污渍的口腔用组合物,其包含3.5〜30重量%的过氧化物和5〜20重量%的磷酸酯聚合物(特别是磷酸聚合的平均链长为10〜 30)。

    PEPTIDE CAPABLE OF BINDING TO IMMUNOGLOBULIN
    7.
    发明申请
    PEPTIDE CAPABLE OF BINDING TO IMMUNOGLOBULIN 失效
    能够与免疫球蛋白结合的肽

    公开(公告)号:US20100167348A1

    公开(公告)日:2010-07-01

    申请号:US12733288

    申请日:2008-08-20

    摘要: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the treatment or prevention of a disease induced by the binding between C1q and an immunoglobulin, which comprises a peptide capable of binding to the immunoglobulin or a fusion protein of the peptide; and others.

    摘要翻译: 公开了:能够结合免疫球蛋白的肽; 肽的融合蛋白; 分别编码肽和融合蛋白的核酸; 分别为肽和融合蛋白的生产方法; 组合物和用于结合免疫球蛋白的手段; 用于治疗或预防由C1q与免疫球蛋白结合引起的疾病的药物组合物,其包含能够结合所述免疫球蛋白的肽或所述肽的融合蛋白; 和别的。

    Cell growth accelerator and cell growth method using the same
    8.
    发明授权
    Cell growth accelerator and cell growth method using the same 有权
    细胞生长促进剂和细胞生长方法使用相同

    公开(公告)号:US06333193B1

    公开(公告)日:2001-12-25

    申请号:US09384384

    申请日:1999-08-27

    申请人: Toshikazu Shiba

    发明人: Toshikazu Shiba

    IPC分类号: C12N500

    摘要: Provided are a cell growth accelerator containing a polyphosphoric acid and a cell growth method in which cells are grown by adding the cell growth accelerator to a medium for cells of animals and plants or by using a glass or plastic cell cultivator containing or coated with the cell growth accelerator. When substances are produced in vitro using culture cells, the cell culture and the cell growth acceleration are conducted at low cost safely and efficiently by adding the cell growth accelerator containing the polyphosphoric acid to the medium for cells of animals and plants or by using the cell cultivator containing or coated with the cell growth accelerator.

    摘要翻译: 提供了含有多磷酸的细胞生长促进剂和细胞生长方法,其中通过将细胞生长促进剂加入到动植物细胞的培养基中或通过使用含有或涂覆有细胞的玻璃或塑料细胞培养器来生长细胞 生长促进剂。 当使用培养细胞体外产生物质时,通过将含有多磷酸的细胞生长促进剂加入到动物和植物细胞的培养基中或通过使用细胞,细胞培养和细胞生长加速以低成本安全有效地进行 培养器含有或涂覆有细胞生长促进剂。

    2-aminothiazoline-4-carboxylate racemase and gene encoding therefor
    9.
    发明授权
    2-aminothiazoline-4-carboxylate racemase and gene encoding therefor 有权
    2-氨基噻唑啉-4-羧酸酯消旋酶及其编码基因

    公开(公告)号:US06214590B1

    公开(公告)日:2001-04-10

    申请号:US09387284

    申请日:1999-08-31

    申请人: Toshikazu Shiba

    发明人: Toshikazu Shiba

    IPC分类号: C12P1312

    CPC分类号: C12P13/12 C12N9/90

    摘要: There is provided a gene for 2-aminothiazoline-4-carboxylate (ATC) racemase, a recombinant DNA comprising the gene or DNA fragment thereof, a transformant or transductant comprising the recombinant DNA, and a process for preparing the 2-aminothiazoline-4-carboxylate racemase using the transformant or transductant. According to the invention, the ATC racemase may be efficiently produced by microorganisms such as E. coli and Pseudomonas and L-cysteine and L-cystine may be efficiently synthesized using the enzyme.

    摘要翻译: 提供了2-氨基噻唑啉-4-羧酸酯(ATC)消旋酶的基因,包含其基因或DNA片段的重组DNA,包含重组DNA的转化体或转导体,以及制备2-氨基噻唑啉-4-羧酸酯 羧酸酯消旋酶,使用转化体或转导体。 根据本发明,ATC消旋酶可以通过诸如大肠杆菌,假单胞菌和L-半胱氨酸的微生物有效地产生,L-胱氨酸可以使用该酶有效合成。

    Peptide capable of binding to immunoglobulin
    10.
    发明授权
    Peptide capable of binding to immunoglobulin 失效
    能结合免疫球蛋白的肽

    公开(公告)号:US08461299B2

    公开(公告)日:2013-06-11

    申请号:US12733288

    申请日:2008-08-20

    摘要: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the treatment or prevention of a disease induced by the binding between C1q and an immunoglobulin, which comprises a peptide capable of binding to the immunoglobulin or a fusion protein of the peptide; and others.

    摘要翻译: 公开了:能够结合免疫球蛋白的肽; 肽的融合蛋白; 分别编码肽和融合蛋白的核酸; 分别为肽和融合蛋白的生产方法; 组合物和用于结合免疫球蛋白的手段; 用于治疗或预防由C1q与免疫球蛋白结合引起的疾病的药物组合物,其包含能够结合所述免疫球蛋白的肽或所述肽的融合蛋白; 和别的。