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公开(公告)号:US08992894B2
公开(公告)日:2015-03-31
申请号:US12304965
申请日:2007-06-14
摘要: An oral stain remover which can remove a stain or a dental plaque effectively without a need of brushing the surface of teeth with a toothbrush or the like, and an oral composition containing the stain remover. An oral stain remover contains a salt of ultraphosphoric acid, and an oral composition contains the oral stain remover.
摘要翻译: 一种口腔除污剂,其可以有效地除去污渍或牙菌斑,而不需要用牙刷等刷牙牙齿表面,以及含有去污剂的口腔组合物。 口腔去污剂含有超磷酸盐,口服组合物含有口腔去污剂。
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公开(公告)号:US20090280072A1
公开(公告)日:2009-11-12
申请号:US12304965
申请日:2007-06-14
摘要: An oral stain remover which can remove a stain or a dental plaque effectively without a need of brushing the surface of teeth with a toothbrush or the like, and an oral composition containing the stain remover. An oral stain remover contains a salt of ultraphosphoric acid, and an oral composition contains the oral stain remover.
摘要翻译: 一种口腔除污剂,其可以有效地除去污渍或牙菌斑,而不需要用牙刷等刷牙牙齿表面,以及含有去污剂的口腔组合物。 口腔去污剂含有超磷酸盐,口服组合物含有口腔去污剂。
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公开(公告)号:US20100040686A1
公开(公告)日:2010-02-18
申请号:US12447158
申请日:2007-10-25
CPC分类号: A61L27/02 , A61K31/43 , A61K31/436 , A61K31/663 , A61K31/704 , A61K33/24 , A61K38/14 , A61K38/1875 , A61K45/06 , A61L27/54 , A61L2300/406 , A61L2300/416 , A61L2300/426 , A61K2300/00
摘要: The present invention provides a biomaterial which releases slowly a biologically active substance acting only on bone cell regeneration, in order to compensate for bone or alveolar bone lost due to surgery, accident or the like. Specifically, the invention relates to a biomaterial containing an osteogenic factor adsorbed on a porous material selected from hydroxyapatite, calcium phosphate, β-TCP (tricalcium phosphate [β-Ca3(PO4)2]), coral, calcium carbonate, titanium oxide, alumina, zirconia, silicon nitride, and ceramics. This osteogenic factor is preferably polyphosphoric acid or a pharmacologically acceptable salt thereof, or else bone morphogenetic protein (BMP).
摘要翻译: 本发明提供一种生物材料,其缓慢释放仅作用于骨细胞再生的生物活性物质,以便补偿由于手术,事故等导致的骨或牙槽骨的损失。 具体地说,本发明涉及一种生物材料,其含有吸附在选自羟基磷灰石,磷酸钙,磷酸三钙(磷酸三钙(Ca4(PO4)2]),珊瑚,碳酸钙,氧化钛 ,氧化铝,氧化锆,氮化硅和陶瓷。 该成骨因子优选为多磷酸或其药理学上可接受的盐,或骨形态发生蛋白(BMP)。
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公开(公告)号:US07329522B2
公开(公告)日:2008-02-12
申请号:US10514726
申请日:2003-05-28
申请人: Toshikazu Shiba , Toshitada Noguchi
发明人: Toshikazu Shiba , Toshitada Noguchi
CPC分类号: C12N9/1229 , C12N9/12 , C12P19/30 , C12P19/32 , C12P19/40
摘要: This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties:(A) action: catalyzing of the following two reactions: NMP+PolyP(n)→NDP+PolyP(n-1) dNMP+POlyP(n)→dNDP+PolyP(n-1) (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP, and TMP;(C) molecular weight: about 55 to 56 Kd (kilodalton); and(D) specific activity: at least 70 units per 1 mg of enzyme protein.
摘要翻译: 本发明涉及新型多磷酸盐:AMP磷酸转移酶(PAP),编码该PAP的基因及其用途。 PAP具有以下性质:(A)作用:催化以下两个反应:<?in-line-formula description =“In-line Formulas”end =“lead”?> NMP + PolyP(n) SUB> - > NDP + PolyP(n-1) sub> <?in-line-formula description =“In-line Formulas”end =“tail”?> <?in-line-formula description =“In-Line Formulas”end =“lead”?> dNMP + POlyP(n) SUB> - > dNDP + PolyP(n-1) SUB> (其中NMP表示核苷单磷酸,NDP表示核苷二磷酸,dNMP表示脱氧核苷单磷酸,dNDP表示脱氧核苷二磷酸,n表示多磷酸酯的聚合度, 整数高达100); (B)底物特异性:特异于AMP,GMP,IMP,dAMP和dGMP,也与CMP,UMP,dCMP和TMP起作用; (C)分子量:约55至56Kd(千道尔顿); 和(D)比活性:每1mg酶蛋白至少70个单位。
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公开(公告)号:US06406711B1
公开(公告)日:2002-06-18
申请号:US09345389
申请日:1999-06-30
申请人: Jin-Yong Lee , Hong-Yeoul Kim , Toshikazu Shiba
发明人: Jin-Yong Lee , Hong-Yeoul Kim , Toshikazu Shiba
IPC分类号: A61F228
CPC分类号: A61L24/02 , A61F2310/00293 , A61L24/0084 , A61L27/12 , A61L27/46 , A61L2430/02
摘要: A bone regeneration material uses polyphosphoric acid and/or a polyphosphate together with a biocompatible material, a filler for cosmetic surgery, or a bone morphogenetic protein, to expedite new bone formation and shorten healing time or restoration in the treatment of bone fractures or damage.
摘要翻译: 骨再生材料使用多磷酸和/或多磷酸盐以及生物相容性材料,整容手术用填充剂或骨形态发生蛋白,以加速新骨形成并缩短愈合时间或恢复治疗骨折或损伤。
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公开(公告)号:US20130189200A1
公开(公告)日:2013-07-25
申请号:US13825555
申请日:2011-09-22
申请人: Toshikazu Shiba , Yumi Kawazoe , Shinichi Kato
发明人: Toshikazu Shiba , Yumi Kawazoe , Shinichi Kato
CPC分类号: A61K8/22 , A61C19/066 , A61K8/24 , A61K8/42 , A61K8/84 , A61K8/86 , A61K2800/75 , A61K2800/81 , A61N5/062 , A61Q11/00
摘要: [Problem] The object of the present invention is to provide an oral composition, which can remove tooth stain effectively. The object of the present invention is also to provide an oral composition, which scarcely damages teeth and gums and can be easily applied.[Method of solution] An oral composition for removing tooth stain, which comprises 3.5 to 30% by weight of peroxide and 5 to 20% by weight of phosphate polymer (in particular, ultraphosphate having an average chain length of phosphoric acid polymerization of 10 to 30).
摘要翻译: 本发明的目的在于提供能有效去除牙齿污渍的口腔用组合物。 本发明的目的还在于提供一种几乎不损伤牙齿和牙龈并且可以容易地应用的口腔用组合物。 [溶液的方法]一种用于除去牙齿污渍的口腔用组合物,其包含3.5〜30重量%的过氧化物和5〜20重量%的磷酸酯聚合物(特别是磷酸聚合的平均链长为10〜 30)。
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公开(公告)号:US20100167348A1
公开(公告)日:2010-07-01
申请号:US12733288
申请日:2008-08-20
申请人: Takahiro Ochi , Toshikazu Shiba , Osamu Masaki
发明人: Takahiro Ochi , Toshikazu Shiba , Osamu Masaki
CPC分类号: C07K14/47 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/472 , C07K2319/00 , G01N33/564
摘要: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the treatment or prevention of a disease induced by the binding between C1q and an immunoglobulin, which comprises a peptide capable of binding to the immunoglobulin or a fusion protein of the peptide; and others.
摘要翻译: 公开了:能够结合免疫球蛋白的肽; 肽的融合蛋白; 分别编码肽和融合蛋白的核酸; 分别为肽和融合蛋白的生产方法; 组合物和用于结合免疫球蛋白的手段; 用于治疗或预防由C1q与免疫球蛋白结合引起的疾病的药物组合物,其包含能够结合所述免疫球蛋白的肽或所述肽的融合蛋白; 和别的。
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公开(公告)号:US06333193B1
公开(公告)日:2001-12-25
申请号:US09384384
申请日:1999-08-27
申请人: Toshikazu Shiba
发明人: Toshikazu Shiba
IPC分类号: C12N500
CPC分类号: C12N5/0018 , A61K8/24 , A61K33/42 , A61Q5/00 , A61Q7/00 , A61Q19/00 , C12N5/0025 , C12N2500/05
摘要: Provided are a cell growth accelerator containing a polyphosphoric acid and a cell growth method in which cells are grown by adding the cell growth accelerator to a medium for cells of animals and plants or by using a glass or plastic cell cultivator containing or coated with the cell growth accelerator. When substances are produced in vitro using culture cells, the cell culture and the cell growth acceleration are conducted at low cost safely and efficiently by adding the cell growth accelerator containing the polyphosphoric acid to the medium for cells of animals and plants or by using the cell cultivator containing or coated with the cell growth accelerator.
摘要翻译: 提供了含有多磷酸的细胞生长促进剂和细胞生长方法,其中通过将细胞生长促进剂加入到动植物细胞的培养基中或通过使用含有或涂覆有细胞的玻璃或塑料细胞培养器来生长细胞 生长促进剂。 当使用培养细胞体外产生物质时,通过将含有多磷酸的细胞生长促进剂加入到动物和植物细胞的培养基中或通过使用细胞,细胞培养和细胞生长加速以低成本安全有效地进行 培养器含有或涂覆有细胞生长促进剂。
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9.
公开(公告)号:US06214590B1
公开(公告)日:2001-04-10
申请号:US09387284
申请日:1999-08-31
申请人: Toshikazu Shiba
发明人: Toshikazu Shiba
IPC分类号: C12P1312
摘要: There is provided a gene for 2-aminothiazoline-4-carboxylate (ATC) racemase, a recombinant DNA comprising the gene or DNA fragment thereof, a transformant or transductant comprising the recombinant DNA, and a process for preparing the 2-aminothiazoline-4-carboxylate racemase using the transformant or transductant. According to the invention, the ATC racemase may be efficiently produced by microorganisms such as E. coli and Pseudomonas and L-cysteine and L-cystine may be efficiently synthesized using the enzyme.
摘要翻译: 提供了2-氨基噻唑啉-4-羧酸酯(ATC)消旋酶的基因,包含其基因或DNA片段的重组DNA,包含重组DNA的转化体或转导体,以及制备2-氨基噻唑啉-4-羧酸酯 羧酸酯消旋酶,使用转化体或转导体。 根据本发明,ATC消旋酶可以通过诸如大肠杆菌,假单胞菌和L-半胱氨酸的微生物有效地产生,L-胱氨酸可以使用该酶有效合成。
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公开(公告)号:US08461299B2
公开(公告)日:2013-06-11
申请号:US12733288
申请日:2008-08-20
申请人: Takahiro Ochi , Toshikazu Shiba , Osamu Masaki
发明人: Takahiro Ochi , Toshikazu Shiba , Osamu Masaki
IPC分类号: C07K7/06 , A61K38/08 , C12N15/12 , G01N33/53 , G01N33/543
CPC分类号: C07K14/47 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/472 , C07K2319/00 , G01N33/564
摘要: Disclosed are: a peptide capable of binding to an immunoglobulin; a fusion protein of the peptide; nucleic acids encoding the peptide and the fusion protein, respectively; production methods for the peptide and the fusion protein, respectively; a composition and a means for binding an immunoglobulin; a pharmaceutical composition for the treatment or prevention of a disease induced by the binding between C1q and an immunoglobulin, which comprises a peptide capable of binding to the immunoglobulin or a fusion protein of the peptide; and others.
摘要翻译: 公开了:能够结合免疫球蛋白的肽; 肽的融合蛋白; 分别编码肽和融合蛋白的核酸; 分别为肽和融合蛋白的生产方法; 组合物和用于结合免疫球蛋白的手段; 用于治疗或预防由C1q与免疫球蛋白结合引起的疾病的药物组合物,其包含能够结合所述免疫球蛋白的肽或所述肽的融合蛋白; 和别的。
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