公开(公告)号：US20090326319A1

公开(公告)日：2009-12-31

申请号：US12549779

申请日：2009-08-28

Applicant: Kazuhiko TAKAHASHI ,  Toshio NAKAMURA

Inventor： Kazuhiko TAKAHASHI ,  Toshio NAKAMURA

IPC: A61B1/018

CPC classification number: A61B17/00234 ,  A61B1/00133 ,  A61B1/018 ,  A61B17/29 ,  A61B18/1492 ,  A61B34/70 ,  A61B34/72 ,  A61B34/74 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2090/0811

Abstract: An endoscope apparatus includes an accessory including an actuation portion configured to be actuated, an operating unit for operating the actuation portion, an endoscope including an accessory insertion pass wherein the accessory is adapted to be inserted through the accessory insertion pass from a proximal end portion of the accessory insertion pass to a distal end portion of the accessory insertion pass, and projected from and retracted into the distal end portion of the accessory insertion pass, a detecting unit configured to detect a condition of a part of the accessory, which is projected from the distal end portion of the accessory insertion pass, and a control unit configured to control an actuation of the actuation portion by an operation to the operating detecting unit.

Abstract translation: 一种内窥镜装置，包括：附件，包括构造成被致动的致动部分，用于操作致动部分的操作单元，包括附件插入通道的内窥镜，其中所述附件适于通过所述附件插入通道从所述附件插入通道的近端部分 所述附件插入通过所述附件插入路径的前端部，并且从所述附件插入路径的前端部突出并缩回到所述附件插入路径的前端部，所述检测单元被配置为检测所述附件的一部分的状态， 附件插入通道的远端部分，以及控制单元，其被配置为通过对操作检测单元的操作来控制致动部分的致动。

公开(公告)号：US20110065667A1

公开(公告)日：2011-03-17

申请号：US12951964

申请日：2010-11-22

Applicant: Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

Inventor： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC: A61K31/695 ,  C07D231/10 ,  C07D413/12 ,  C07D281/06 ,  C07F7/10 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/553 ,  A61P25/28 ,  A61P25/18 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P25/00

CPC classification number: C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

公开(公告)号：US20110106141A1

公开(公告)日：2011-05-05

申请号：US12847260

申请日：2010-07-30

Applicant: Toshio NAKAMURA

Inventor： Toshio NAKAMURA

IPC: A61B17/28

CPC classification number: A61B34/30 ,  A61B18/1442 ,  A61B34/71 ,  A61B2017/00867 ,  A61B2018/00345 ,  A61B2018/00404 ,  A61B2018/00619 ,  A61B2034/301 ,  A61B2090/065 ,  C08L2201/12

Abstract: A robot system for endoscopic treatment includes a gripping unit, a manipulator unit, a treatment instrument drive unit, a gripping force detection unit, a control unit. The gripping unit is inserted into a body cavity along with an endoscopic apparatus and grips desired living tissue using gripping members. The manipulator unit includes a multi-joint structure that enables bending and stretching. The treatment instrument drive unit pulls and pays out wires. The gripping force detection unit detects gripping force provided by the gripping members. The control unit instructs the treatment instrument drive unit to pull and pay out the wires for the gripping operation so that the gripping force detected by the gripping force detection unit falls within a predetermined range when the gripping unit in the gripping state moves.

Abstract translation: 用于内窥镜治疗的机器人系统包括夹持单元，操纵器单元，治疗仪器驱动单元，夹紧力检测单元，控制单元。 夹持单元与内窥镜装置一起插入体腔中，并使用夹持构件夹住期望的生物组织。 机械手单元包括能够弯曲和拉伸的多关节结构。 治疗仪器驱动单元拉出并送出电线。 夹持力检测单元检测由夹持构件提供的夹持力。 控制单元指示治疗仪器驱动单元拉动并支付用于夹紧操作的线，使得当握持状态下的夹持单元移动时，由夹持力检测单元检测到的夹持力落在预定范围内。

公开(公告)号：US20110065668A1

公开(公告)日：2011-03-17

申请号：US12951978

申请日：2010-11-22

Applicant: Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

Inventor： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC: A61K31/695 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/553 ,  A61P25/28 ,  A61P25/18 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P25/00

CPC classification number: C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

Abstract translation: 本发明提供了用于痴呆，阿尔茨海默病，注意缺陷多动障碍，精神分裂症，进食障碍，肥胖症，糖尿病，高脂血症，睡眠障碍，发作性睡眠障碍，睡眠呼吸暂停综合征，昼夜节律紊乱，抑郁，过敏性鼻炎或 其他疾病 由式（1）表示的苯基吡唑衍生物或其药学上可接受的盐：其中可以相同或不同的R 1和R 2各自表示C 1 -C 6烷基或C 3 -C 8环烷基，或者R 1和R 2各自连接 与其相邻的氮原子一起形成4-至7-元饱和杂环（其中所述饱和杂环可被卤素或C 1 -C 6烷基取代），n表示0至2的整数，T表示氢 原子，卤素或C 1 -C 6烷基，R表示式（I）：等）。

公开(公告)号：US20090326325A1

公开(公告)日：2009-12-31

申请号：US12556956

申请日：2009-09-10

Applicant: Kimihiko NAITO ,  Tsutomu ISHIGURO ,  Jun HASEGAWA ,  Toshio NAKAMURA

Inventor： Kimihiko NAITO ,  Tsutomu ISHIGURO ,  Jun HASEGAWA ,  Toshio NAKAMURA

IPC: A61B1/008

CPC classification number: A61B1/0055 ,  A61B1/00133 ,  A61B1/0057 ,  A61B17/29 ,  A61B34/70 ,  A61B34/71 ,  A61B2017/003 ,  A61B2017/2901 ,  A61B2017/2908 ,  A61B2017/2927 ,  A61B2017/2929 ,  A61B2017/2947 ,  A61B2034/742

Abstract: A multijointed bending mechanism having a first bending piece, a second bending piece connected to the first bending piece so as to be rotatable around a first rotation shaft, a third bending piece connected to the second bending piece so as to be rotatable around a second rotation shaft, at least two first wires connected to the first bending piece to rotate the first bending piece and at least two second wires connected to the second bending piece to rotate the second bending piece. The second wires are disposed inwards of the first wires with respect to a vertical direction of the first and second rotation shafts.

Abstract translation: 一种多关节弯曲机构，具有第一弯曲块，第二弯曲块，连接到第一弯曲块，以便围绕第一旋转轴旋转;第三弯曲块，连接到第二弯曲块，以便能够围绕第二旋转 轴，连接到第一弯曲块以使第一弯曲块旋转的至少两个第一线和连接到第二弯曲块的至少两个第二线，以旋转第二弯曲块。 相对于第一旋转轴和第二旋转轴的垂直方向，第二线材布置在第一线材的内侧。

公开(公告)号：US20080188767A1

公开(公告)日：2008-08-07

申请号：US12029897

申请日：2008-02-12

Applicant: Yoshinao OAKI ,  Sachiko KARAKI ,  Yutaka OTANI ,  Kiyotsugu KOJIMA ,  Tatsuya SAITO ,  Toshio NAKAMURA ,  Tsutomu ISHIGURO ,  Sugio MANABE ,  Koji TAKAMURA ,  Hiroko SAKAMOTO

Inventor： Yoshinao OAKI ,  Sachiko KARAKI ,  Yutaka OTANI ,  Kiyotsugu KOJIMA ,  Tatsuya SAITO ,  Toshio NAKAMURA ,  Tsutomu ISHIGURO ,  Sugio MANABE ,  Koji TAKAMURA ,  Hiroko SAKAMOTO

IPC: A61B10/04 ,  A61B1/018

CPC classification number: A61B1/018 ,  A61B10/0096 ,  A61B10/0283 ,  A61B10/04 ,  A61B17/3403 ,  A61B17/3478 ,  A61B2010/045

Abstract: An endoscopic therapeutic device includes an elongated insertion section which is inserted into a living body through a therapeutic device channel of an endoscope, a tubular puncture needle which is disposed at a distal end portion of the insertion section and is made to pierce a living body tissue, a syringe for sampling the living body tissue in a state in which the puncture needle pierces the living body tissue, and a freezing device for subjecting the living body tissue, which is collected by the syringe, to a process for analysis.

Abstract translation: 内窥镜治疗装置包括：细长插入部，其通过内窥镜的治疗装置通道插入生物体;管状穿刺针，其设置在所述插入部的前端部，并且穿刺所述生物体组织 用于在穿刺针穿刺生物体组织的状态下取样生物体组织的注射器，以及将由注射器收集的生物体组织进行分析处理的冷冻装置。

公开(公告)号：US20110257480A1

公开(公告)日：2011-10-20

申请号：US13092702

申请日：2011-04-22

Applicant: Kazuhiko TAKAHASHI ,  Toshio NAKAMURA

Inventor： Kazuhiko TAKAHASHI ,  Toshio NAKAMURA

IPC: A61B1/00

CPC classification number: B25J9/06 ,  A61B1/00147 ,  A61B1/0052 ,  A61B1/0055 ,  A61B5/065 ,  A61B34/30 ,  A61B34/37 ,  A61B2034/2059 ,  A61B2034/306 ,  A61B2090/064

Abstract: A multijoint manipulator apparatus includes a tubular-member, linear-motion-transmission-members, a drive-unit, a position-detector, a tension-detector, an operation-unit, and a movement-degree-calculation-unit. The linear-members are inserted in the tubular-member, one end and the other end of each of the linear-members being fixed to the vicinity of a joint of the tubular-member and the drive-unit, respectively. The drive-unit moves the linear-members. The position-detector and the tension-detector detect positions and tension of the linear-members, respectively. A desired position/posture of a point of interest is input to the operation-unit. The calculation-unit calculates a current position/posture of the point, a weighting factor serving to give priority to and move the linear-members the tension of which is relatively low among the linear-members, and movement degrees of the linear-members to move the point to the desired position/posture, and causes the drive-unit to pull the linear-members.

Abstract translation: 多关节机械手装置包括管状构件，直线运动传递构件，驱动单元，位置检测器，张力检测器，操作单元和移动程度计算单元。 线性构件插入管状构件中，每个线性构件的一端和另一端分别固定在管状构件和驱动单元的接头附近。 驱动单元移动线性元件。 位置检测器和张力检测器分别检测线性元件的位置和张力。 将感兴趣点的期望位置/姿势输入到操作单元。 计算单元计算点的当前位置/姿势，用于优先使线性构件中的线性构件的张力相对较低的直线构件的加权系数和线性构件的移动度向 将点移动到期望的位置/姿势，并且使驱动单元拉动线性构件。

公开(公告)号：US20100204547A1

公开(公告)日：2010-08-12

申请号：US12764482

申请日：2010-04-21

Applicant: Hideki TANAKA ,  Jun HASEGAWA ,  Toshio NAKAMURA

Inventor： Hideki TANAKA ,  Jun HASEGAWA ,  Toshio NAKAMURA

IPC: A61B1/005

CPC classification number: G02B23/2476 ,  A61B1/0051 ,  A61B5/06 ,  A61B5/062

Abstract: An endoscope bending control apparatus includes: an image feature value calculating section for calculating, based on an endoscopic image, an image feature value related to a luminal dark part; a bending control section for performing bending control on a bending portion in either one of a first bending operation mode in which a position of the luminal dark part is set as an insertion target and a distal end of the insertion portion is directed to the position and a second bending operation mode in which the distal end of the insertion portion is directed in a direction of the position of the luminal dark part; an operation mode switching section for switching an operation mode from one bending operation mode to the other according to a first switching condition based on the calculated image feature value; and a switching condition changing section for changing the first switching condition.

Abstract translation: 内窥镜弯曲控制装置包括：图像特征量计算部，其根据内窥镜图像计算与管腔暗部相关的图像特征量; 弯曲控制部分，用于在其中将管腔暗部分的位置设置为插入目标的第一弯曲操作模式和插入部分的远端中的任一个中的弯曲部分上进行弯曲控制， 第二弯曲操作模式，其中插入部分的远端沿着管腔暗部位置的方向指向; 操作模式切换部分，用于根据所计算的图像特征值根据第一切换条件将操作模式从一个弯曲操作模式切换到另一个; 以及用于改变第一开关状态的开关条件改变部分。

公开(公告)号：US20100204545A1

公开(公告)日：2010-08-12

申请号：US12763514

申请日：2010-04-20

Applicant: Hideki TANAKA ,  Jun HASEGAWA ,  Toshio NAKAMURA

Inventor： Hideki TANAKA ,  Jun HASEGAWA ,  Toshio NAKAMURA

IPC: A61B1/04

CPC classification number: G02B23/2476 ,  A61B1/0005 ,  A61B1/0051 ,  A61B1/0052 ,  A61B1/042 ,  A61B5/065 ,  H04N7/185

Abstract: An endoscope system of the invention includes: an endoscope including an insertion portion, a distal end portion provided on a distal end side of the insertion portion, and a bending portion which is capable of changing a position and an orientation of the distal end portion; a position detecting section for acquiring position information on a position where the distal end portion is located; a passing target position setting section for setting a passing target position for the distal end portion; a path estimating section for estimating a path through which the distal end portion is to be passed; a bending control target position setting section for setting a bending control target position such that the distal end portion reaches the passing target position along the path; and a bending control information calculating section for calculating an amount of bending and a bending direction of the bending portion.

Abstract translation: 本发明的内窥镜系统包括：内窥镜，具有插入部，设置在所述插入部的前端侧的前端部和能够改变前端部的位置和姿态的弯曲部; 位置检测部分，用于获取关于所述远端部分所在位置的位置信息; 通过目标位置设定部，用于设定前端部的通过目标位置; 路径估计部，用于估计要通过所述远端部的路径; 弯曲控制对象位置设定部，其设定使所述前端部沿着所述路径到达所述通过目标位置的弯曲控制对象位置; 以及弯曲控制信息计算部分，用于计算弯曲部分的弯曲量和弯曲方向。

公开(公告)号：US20100076263A1

公开(公告)日：2010-03-25

申请号：US12629987

申请日：2009-12-03

Applicant: Hideki TANAKA ,  Jun HASEGAWA ,  Toshio NAKAMURA ,  Akio UCHIYAMA ,  Atsushi CHIBA

Inventor： Hideki TANAKA ,  Jun HASEGAWA ,  Toshio NAKAMURA ,  Akio UCHIYAMA ,  Atsushi CHIBA

IPC: A61B1/00 ,  A61B1/04

CPC classification number: A61B1/041 ,  A61B1/00006 ,  A61B1/00009 ,  A61B1/00147 ,  A61B1/00158 ,  A61B1/0016 ,  A61B1/0051 ,  A61B5/062 ,  A61B5/065 ,  A61B34/73

Abstract: An endoscope system includes: an endoscope for picking up an image in a body cavity by an image pickup apparatus provided in a distal end of an insertion portion; a position detecting apparatus for detecting, based on luminal information acquired by the image pickup apparatus, position information used for inserting the distal end of the insertion portion; a recording apparatus for recording, in a time-sequential manner, the position information detected by the position detecting apparatus; a determining apparatus for determining whether or not the detecting operation of the position information performed by the position detecting apparatus satisfies a set condition; and a direction calculating apparatus for, when the determination result shows that the set condition is not satisfied, reading out the position information recorded in the recording apparatus and outputting information on a direction in which the distal end of the insertion portion is to be inserted.

Abstract translation: 内窥镜系统包括：内窥镜，用于通过设置在插入部的前端的图像拾取装置拾取体腔内的图像; 位置检测装置，用于基于由图像拾取装置获取的管腔信息来检测用于插入插入部分的远端的位置信息; 一种用于以时间顺序方式记录由位置检测装置检测的位置信息的记录装置; 确定装置，用于确定由位置检测装置执行的位置信息的检测操作是否满足设定条件; 以及方向计算装置，当确定结果表示不满足设定条件时，读出记录在记录装置中的位置信息并输出关于插入部分的前端的方向的信息。