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公开(公告)号：US09308296B2
公开(公告)日：2016-04-12
申请号：US14269287
申请日：2014-05-05
CPC分类号： A61L27/3687 , A61F2/4644 , A61L27/3608 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： A tissue treatment apparatus and method for treating biologic tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the tissue sample is bone material and the treatment procedure effects demineralization of the bone material.
摘要翻译： 用于处理生物组织的组织处理装置和方法具有控制器，外壳，试剂供应系统，排水构造和气体释放阀，由控制器控制。 任选地，提供气体排出组件，气体供应单元，用于加热或冷却试剂或气体的热单元，超声处理单元，由控制器操作的任何或每个。 该方法提供了编程控制器来实现治疗过程。 在本申请的一个实施方案中，组织样品是骨材料，并且处理过程影响骨材料的脱矿质。
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公开(公告)号：US11660196B2
公开(公告)日：2023-05-30
申请号：US15493236
申请日：2017-04-21
IPC分类号： A61F2/28 , B33Y10/00 , B33Y50/02 , B33Y80/00 , B33Y70/10 , B29C64/171 , A61F2/30 , A61L27/58 , A61L27/36 , A61L27/54 , A61F2/44 , A61L27/18 , A61L27/56 , B29C64/386 , A61L27/04 , B29L31/00
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/2846 , A61F2/4455 , A61L27/18 , A61L27/3608 , A61L27/54 , A61L27/56 , A61L27/58 , B29C64/171 , B29C64/386 , B33Y10/00 , B33Y50/02 , B33Y70/10 , B33Y80/00 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2002/30948 , A61F2002/30952 , A61F2002/30962 , A61F2002/30971 , A61F2002/30985 , A61F2310/00041 , A61F2310/00359 , A61L27/04 , A61L2400/06 , A61L2430/02 , B29K2995/0056 , B29L2031/7532 , A61L27/18 , C08L67/04
摘要： Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.
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公开(公告)号：US20210180019A1
公开(公告)日：2021-06-17
申请号：US17166491
申请日：2021-02-03
摘要： A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.
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公开(公告)号：US10660685B2
公开(公告)日：2020-05-26
申请号：US14940979
申请日：2015-11-13
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61B17/88 , A61F2/46 , A61F2/28 , B01F15/02 , A61F2/30 , A61L27/36 , A61L27/54 , B01F13/00 , B01F13/06 , B01F15/00
摘要： A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.
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公开(公告)号：US20180303616A1
公开(公告)日：2018-10-25
申请号：US15493236
申请日：2017-04-21
IPC分类号： A61F2/30 , A61F2/28 , A61L27/04 , A61L27/58 , A61L27/36 , A61L27/54 , A61L27/14 , B29C67/00 , B33Y10/00 , B33Y50/02 , B33Y80/00
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/2846 , A61F2/4455 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2002/30948 , A61F2002/30952 , A61F2002/30962 , A61F2002/30971 , A61F2310/00041 , A61F2310/00359 , A61L27/04 , A61L27/14 , A61L27/3608 , A61L27/54 , A61L27/58 , A61L2430/02 , B29C67/0088 , B29K2995/0056 , B29L2031/7532 , B33Y10/00 , B33Y50/02 , B33Y80/00
摘要： Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.
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公开(公告)号：US20160250025A1
公开(公告)日：2016-09-01
申请号：US15149920
申请日：2016-05-09
发明人： Deger C. Tunc , John Winterbottom , David R. Kaes , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
摘要翻译： 一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。 复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。 植入后，可以将复合材料设置成为植入物提供机械强度。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。 本发明还提供了使用和制备可模制和可流动的复合材料的方法。
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公开(公告)号：US20160231056A1
公开(公告)日：2016-08-11
申请号：US14617170
申请日：2015-02-09
IPC分类号： F26B5/04
摘要： Methods for treating bulk bone tissue are provided. The methods comprise contacting bulk bone tissue or frozen bulk bone tissue with an effective amount of a supercritical fluid so as to dry the bulk bone tissue. In various embodiments, the supercritical fluid destroys contaminants such that the frozen bulk bone tissue is 99.9% substantially pure. In various embodiments, contaminants removed from the frozen bulk bone tissue include lipids, viruses, bacteria, pyrogens, prions, micro-organisms and/or pathogens. In some embodiments, the supercritical fluid causes a 3 log reduction of bacteria within the frozen bulk bone tissue.
摘要翻译： 提供了治疗大块骨组织的方法。 所述方法包括使大块骨组织或冷冻块状骨组织与有效量的超临界流体接触，以便干燥大块骨组织。 在各种实施方案中，超临界流体破坏污染物，使得冻结的体积骨组织基本上纯度为99.9％。 在各种实施方案中，从冷冻块状骨组织中去除的污染物包括脂质，病毒，细菌，热原，朊病毒，微生物和/或病原体。 在一些实施方案中，超临界流体导致冷冻体内骨组织内的细菌减少3log。
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公开(公告)号：US20160135954A1
公开(公告)日：2016-05-19
申请号：US14941033
申请日：2015-11-13
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
CPC分类号： A61B17/8816 , A61B17/8805 , A61B2017/8838 , A61F2/28 , A61F2/30942 , A61F2/4601 , A61F2/4644 , A61F2002/2835 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/54 , A61L2300/412 , A61L2430/02 , B01F13/0023 , B01F13/06 , B01F15/00506 , B01F15/0278
摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.
摘要翻译： 提供了一种用于与液体水合的骨材料，所述骨材料包括碾磨和去矿化的骨纤维的相干团块，所述相干团块没有布置在所述相干团块中或所述相干团块上的粘合剂。 在一些实施例中，提供了用于与液体水合的骨材料，所述骨材料包括筒式研磨，冻干和软化的骨纤维的相干团块，所述相干团块在所述相干团块上不具有粘合剂。 在一些实施例中，提供了一种植入骨材料的方法，所述方法包括使骨材料与液体接触，所述骨材料包括柱塞研磨的，冻干和软化的骨纤维的相干团块，所述粘合剂物质不具有粘合剂 或连贯质量; 将骨材料模制成植入骨材料的形状; 以及将骨材料植入目标组织部位。
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公开(公告)号：US11903627B2
公开(公告)日：2024-02-20
申请号：US16879347
申请日：2020-05-20
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61B17/00 , A61B17/88 , A61F2/46 , B01F33/70 , B01F33/501 , B01F35/32 , B01F35/75 , A61J1/20 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8816 , A61B17/8805 , A61F2/28 , A61F2/30942 , A61F2/4644 , A61J1/20 , A61L27/365 , A61L27/3608 , A61L27/3683 , A61L27/3691 , A61L27/54 , B01F33/50112 , B01F33/70 , B01F35/3202 , B01F35/75425 , A61B2017/8838 , A61F2/4601 , A61F2002/2835 , A61L2300/412 , A61L2430/02
摘要： A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.
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公开(公告)号：US10080661B2
公开(公告)日：2018-09-25
申请号：US15149920
申请日：2016-05-09
发明人： Deger C. Tunc , John Winterbottom , David R. Kaes , Todd Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
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