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公开(公告)号：US11911406B2
公开(公告)日：2024-02-27
申请号：US17171463
申请日：2021-02-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Mingzhou Ye
IPC: A61K31/7048 , A61K47/59 , A61P31/04 , A61K31/4409 , A61K31/7056 , A61K31/496 , A61K38/14 , A61K31/426 , A61K31/7036 , C08G69/10
CPC classification number: A61K31/7048 , A61K31/426 , A61K31/4409 , A61K31/496 , A61K31/7036 , A61K31/7056 , A61K38/14 , A61K47/595 , A61P31/04 , C08G69/10
Abstract: Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug linked to the cationic polymer by a pH-sensitive linker. The masked cationic functional groups may be converted in aqueous solution to free cationic functional groups faster at a pH below 7 than a pH above 7. The cationic functional groups may be masked as either an uncharged functional group or by an ion pair with a neighboring anionic functional group attached to the polymer. The pH-sensitive linker releases the drug faster in aqueous solution at or below a pre-determined pH value selected from a range of 4.5 to 7 than a pH value above 7.
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公开(公告)号：US11446392B2
公开(公告)日：2022-09-20
申请号：US17057415
申请日：2019-05-23
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20180182911A1
公开(公告)日：2018-06-28
申请号：US15865662
申请日：2018-01-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Kanglin Xiong , Hongyi Mi , Tzu-Hsuan Chang , Shaoqin Gong , Jung-Hun Seo
IPC: H01L31/0693
CPC classification number: H01L31/0693 , Y02E10/544 , Y02P70/521
Abstract: Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and transfer printing are provided. The tandem solar cells have improved tunnel junction structures comprising a current tunneling layer integrated between the p and n layers of the pn diode tunnel junction that connects the solar cells.
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公开(公告)号：US09437628B1
公开(公告)日：2016-09-06
申请号：US14709850
申请日：2015-05-12
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Yei Hwan Jung , Shaoqin Gong , Tzu-Hsuan Chang
IPC: H01L29/00 , H01L21/8234 , H01L21/8244 , H01L27/13 , H01L21/84
CPC classification number: H01L27/13 , H01L21/84 , H01L51/0013 , H01L51/0097
Abstract: Substantially biodegradable microwave integrated circuits and method for making the microwave integrated circuits are provided. The integrated circuits, which have applications in high performance flexible microwave and digital electronics, utilize biobased, biodegradable cellulose nanofibril films as a substrate and comprise only very small amounts of potentially toxic inorganic materials.
Abstract translation: 提供了基本可生物降解的微波集成电路和制造微波集成电路的方法。 在高性能柔性微波和数字电子应用中的集成电路利用生物基的可生物降解的纤维素纳米纤维膜作为基底，并且仅包含非常少量的潜在有毒的无机材料。
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公开(公告)号：US20250127921A1
公开(公告)日：2025-04-24
申请号：US18682418
申请日：2022-08-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Ruosen Xie , Xiuxiu Wang
Abstract: Provided herein are self-assembled nanoparticles (NPs), pharmaceutical compositions containing such NPs and methods of using such NPs. The NPs comprise an amphiphilic copolymer and a ribonucleoprotein (RNP), and optionally ssODN, wherein: the amphiphilic copolymer is a water-soluble block copolymer comprising a poly(C2-3 alkylene glycol) block and an acrylic block comprising a poly(acrylate), poly(methacrylate) or poly(acrylate/methacrylate) block; the acrylic block comprise ester side chains bearing substituted or unsubstituted alkylamine groups; and the RNP, ssODN, and the acrylic block of the amphiphilic copolymer form a core of the self-assembled nanoparticle, and the poly(ethylene glycol) block of the amphiphilic copolymer forms the exterior of the self-assembled nanoparticle.
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Patent Agency Ranking
公开(公告)号：US20240327457A1
公开(公告)日：2024-10-03
申请号：US18434662
申请日：2024-02-06
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Min Zhu , Xianghui Xu
IPC: C07K5/02 , A61K9/51 , A61K31/7105 , A61K31/711 , C07K1/107
CPC classification number: C07K5/0215 , A61K9/5123 , A61K31/7105 , A61K31/711 , C07K1/1077
Abstract: The present technology provides disulfide-containing lipopeptides of Formula I. Such lipids may be incorporated into lipid nanoparticles for delivery of nucleic acids, nucleotides (e.g., NAD+ or NADH), polypeptides (including proteins), and complexes of proteins and nucleic acids, e.g., Cas9 RNP. The present technology also provides methods for delivering the nanoparticles to a cell and methods of treating a condition or disorder using the lipid nanoparticles.
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公开(公告)号：US20230346972A1
公开(公告)日：2023-11-02
申请号：US17932736
申请日：2022-09-16
Inventor： K. Craig Kent , Shaoqin Gong , Lianwang Guo , Bowen Wang , Guojun Chen , Go Urabe
CPC classification number: A61K47/6937 , A61K9/5153 , A61K45/06 , B82Y5/00
Abstract: The present disclosure relates to unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. The disclosed compositions are useful for treating a subject with a disease or condition, such as a cardiovascular disease. In a further aspect, the cardiovascular disease can be a vascular stenosis or restenosis. Also described herein are methods of making and using the unimolecular core-shell nanoparticle, nanoclusters thereof, and platelet biomimetic nanoclusters thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US20180290891A1
公开(公告)日：2018-10-11
申请号：US15901352
申请日：2018-02-21
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Qifeng Zheng
Abstract: Electrically conductive aerogel films, electrodes composed of the electrically conductive aerogel films, and supercapacitors incorporating the electrodes are provided. The aerogel films include reduced graphene oxide particles in combination with metal oxynitride fibers. By including cellulosic nanofibrils in the aerogels, the films can be made mechanically flexible and free-standing.
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公开(公告)号：US20250041237A1
公开(公告)日：2025-02-06
申请号：US18790293
申请日：2024-07-31
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Jingcheng Zhu
IPC: A61K9/51 , A61K31/137 , A61K31/438 , A61K31/505 , A61K31/635 , A61K31/7135 , A61K45/06 , A61P31/04
Abstract: A nanoparticle comprising a core and a shell, wherein the core includes an antimicrobial and hemoglobin, the shell includes a polyunsaturated fatty acids (PUFA)-containing cell membrane, and the antimicrobial sensitizes bacteria to oxidant killing.
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公开(公告)号：US20240132823A1
公开(公告)日：2024-04-25
申请号：US17769549
申请日：2020-10-11
Applicant: Wisconsin Alumni Research Foundation
Inventor： Zhenqiang Ma , Inkyu Lee , Juhwan Lee , Michael Phillips , David Gamm , Shaoqin Gong
IPC: C12M1/12 , C12N5/0793
CPC classification number: C12M25/14 , C12N5/062 , C12N2533/30
Abstract: Photoreceptor scaffolds that can be used for transplantation of organized photoreceptor tissue, with or without retinal pigment epithelial cells, which may improve grafted cell survival, integration, and functional visual rescue are disclosed herein. The scaffolds include a cell support layer having at least one honeycomb-shaped reservoir fluidly connected to a plurality of through-holes and at least one cell in the at least one honeycomb-shaped reservoir.
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